Article ; Online: Identification of SARS-CoV-2 on the ocular surface in a cohort of COVID-19 patients from Brazil.
Experimental biology and medicine (Maywood, N.J.)
2021 Volume 246, Issue 23, Page(s) 2495–2501
Abstract: ... Coronavirus 2 Ribonucleic Acid (SARS-CoV-2 RNA) in the tears of hospitalized COVID-19 patients. After ... 2 detected in tears than in patients without virus in ocular surface samples. One patient with SARS ... manifestations were evaluated. Of the 83 patients enrolled in the study, 7 (8.43%) had SARS-CoV-2 RNA detected ...
| Abstract | In this cross-sectional study, we investigate the presence of Severe Acute Respiratory Syndrome Coronavirus 2 Ribonucleic Acid (SARS-CoV-2 RNA) in the tears of hospitalized COVID-19 patients. After laboratory confirmation of SARS-CoV-2 infection by reverse transcription polymerase chain reaction (RT-PCR) analysis, tear samples from both eyes of each patient were collected using conjunctival swab for RT-PCR. Detailed demographic profile, systemic and ocular symptoms, comorbidities, clinical, ancillary, and ocular manifestations were evaluated. Of the 83 patients enrolled in the study, 7 (8.43%) had SARS-CoV-2 RNA detected in the tear samples. Neutrophils' count, C-reactive protein, and D-dimer were higher in patients with SARS-CoV-2 detected in tears than in patients without virus in ocular surface samples. One patient with SARS-CoV-2 in tears showed mild ocular eyelid edema, hyperemia, and chemosis. No relevant ocular manifestations were detected in the other patients. Although the levels of viral RNA on ocular surface samples were low for most patients (5/7), with positivity only for gene |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Adult ; Aged ; Brazil ; COVID-19/complications ; COVID-19/pathology ; COVID-19/virology ; COVID-19 Nucleic Acid Testing/statistics & numerical data ; Eye/virology ; Eye Infections, Viral/epidemiology ; Eye Infections, Viral/pathology ; Eye Infections, Viral/virology ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2/genetics ; SARS-CoV-2/pathogenicity ; Tears/virology ; Viral Load | |||||
| Language | English | |||||
| Publishing date | 2021-07-19 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 4015-0 | |||||
| ISSN | 1535-3699 ; 1525-1373 ; 0037-9727 | |||||
| ISSN (online) | 1535-3699 ; 1525-1373 | |||||
| ISSN | 0037-9727 | |||||
| DOI | 10.1177/15353702211024651 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ua VI Zs.111: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.