Article ; Online: Decrease of Non-Classical and Intermediate Monocyte Subsets in Severe Acute SARS-CoV-2 Infection.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
2020 Volume 97, Issue 9, Page(s) 887–890
Abstract: ... a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. Conversely in patients ... patients with different manifestations of acute SARS-CoV-2 infection were investigated ... In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive ...
| Abstract | In patients with severe SARS-CoV-2 infection, the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non-classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study, 30 patients with different manifestations of acute SARS-CoV-2 infection were investigated with a flow cytometric study of NC, INT, and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a downregulated HLA-DR were found in acute patients with severe SARS-CoV-2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. © 2020 International Society for Advancement of Cytometry. |
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| MeSH term(s) | Aged ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; Biomarkers/analysis ; CD11b Antigen/analysis ; COVID-19 ; Cell Separation ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Female ; Flow Cytometry ; Host Microbial Interactions ; Humans ; Leukocytes ; Male ; Middle Aged ; Monocytes/immunology ; Monocytes/virology ; Pandemics ; Phenotype ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index |
| Chemical Substances | Biomarkers ; CD11b Antigen ; ITGAM protein, human |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-14 |
| Publishing country | United States |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 2099868-5 |
| ISSN | 1552-4930 ; 0196-4763 ; 1552-4922 |
| ISSN (online) | 1552-4930 |
| ISSN | 0196-4763 ; 1552-4922 |
| DOI | 10.1002/cyto.a.24188 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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