Article ; Online: Clinical characteristics and predictors of mortality in African-Americans with COVID-19 from an inner-city community teaching hospital in New York.
2020 Volume 93, Issue 2, Page(s) 812–819
Abstract: ... community hospital in New York city. Demographics, clinical presentation, baseline co-morbidities, and laboratory ... protein, and D-dimers are independent predictors of mortality among hospitalized AAs with COVID-19 ... review, we included all AA patients with confirmed COVID-19 infection admitted to an inner-city teaching ...
| Abstract | There is limited data on the clinical presentation and predictors of mortality in the African-American (AA) patients hospitalized with coronavirus disease 2019 (COVID-19) despite the disproportionately higher burden and mortality. The aim of this study is to report on the clinical characteristics and the predictors of mortality in hospitalized AA patients with COVID-19 infection. In this retrospective cohort review, we included all AA patients with confirmed COVID-19 infection admitted to an inner-city teaching community hospital in New York city. Demographics, clinical presentation, baseline co-morbidities, and laboratory data were compared between survivors and non-survivors. The predictors of mortality were assessed using multivariate logistic regression analysis. Of the 408 (median age, 67 years) patients included, 276 (66.65%, median age 63 years) survived while 132 (33.35%, median age 71 years) died. The most common presenting symptoms were cough, myalgia, fever/chills, shortness of breath, and gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain), with a prevalence of 62.50%, 43.87%, 53.68%, and 27.21%, respectively. Age (odds ratio [OR], 1.06; confidence interval [CI], 1.04-1.08; P < .001), body mass index (OR, 1.07; CI, 1.04-1.11; P < .001), elevated serum ferritin (OR, 1.99; CI, 1.08-3.66; P < .02), C-reactive protein (OR, 2.42; CI, 1.36-4.33; P < .01), and D-dimers (OR, 3.79; CI, 2.21-6.50; P < .001) at the time of presentation were identified as the independent predictors of mortality. Cough, shortness of breath, fever/chills, gastrointestinal symptoms, and myalgia were the predominant presentation among AAs hospitalized with COVID-19 infection. Advanced age, higher body mass index, elevated serum ferritin, C-reactive protein, and D-dimers are independent predictors of mortality among hospitalized AAs with COVID-19 infection. |
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| MeSH term(s) | African Americans ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Body Mass Index ; C-Reactive Protein/metabolism ; COVID-19/diagnosis ; COVID-19/ethnology ; COVID-19/mortality ; COVID-19/pathology ; Female ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/metabolism ; Hospitals, Community ; Hospitals, Teaching ; Humans ; Intensive Care Units ; Logistic Models ; Male ; Middle Aged ; New York City ; Odds Ratio ; Predictive Value of Tests ; Retrospective Studies ; SARS-CoV-2/pathogenicity ; Severity of Illness Index |
| Chemical Substances | Biomarkers ; Fibrin Fibrinogen Degradation Products ; fibrin fragment D ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-10-05 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 752392-0 |
| ISSN | 1096-9071 ; 0146-6615 |
| ISSN (online) | 1096-9071 |
| ISSN | 0146-6615 |
| DOI | 10.1002/jmv.26306 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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