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  1. Article ; Online: Salvaging CNS Clinical Trials Halted Due to COVID-19.

    Geerts, Hugo / van der Graaf, Piet H

    CPT: pharmacometrics & systems pharmacology

    2020  Volume 9, Issue 7, Page(s) 367–370

    MeSH term(s) Alzheimer Disease/drug therapy ; Betacoronavirus ; COVID-19 ; Central Nervous System Diseases/drug therapy ; Clinical Trials as Topic ; Computer Simulation ; Coronavirus Infections ; Data Accuracy ; Datasets as Topic ; Humans ; Pandemics ; Parkinson Disease/drug therapy ; Patient-Specific Modeling ; Pneumonia, Viral ; SARS-CoV-2 ; Systems Analysis
    Keywords covid19
    Language English
    Publishing date 2020-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Salvaging CNS Clinical Trials Halted Due to COVID‐19

    Geerts, Hugo / Graaf, Piet H.

    CPT: Pharmacometrics & Systems Pharmacology

    2020  Volume 9, Issue 7, Page(s) 367–370

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2697010-7
    ISSN 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12535
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Salvaging CNS Clinical Trials Halted Due to COVID‐19

    Hugo Geerts / Piet H. van derGraaf

    CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 367-

    2020  Volume 370

    Keywords Therapeutics. Pharmacology ; RM1-950 ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article: Salvaging CNS Clinical Trials halted due to COVID-19

    Geerts, Hugo / van der Graaf, Piet H

    CPT: pharmacomet. syst. pharmacol

    Abstract: The COVID-19 pandemic has halted many ongoing CNS clinical trials, especially ... in Alzheimer's disease. These long-duration trials involve many stakeholders, especially the patients and ... trials because of the pandemic. While some of these trials will need to restart, others can re-start ...

    Abstract The COVID-19 pandemic has halted many ongoing CNS clinical trials, especially in Alzheimer's disease. These long-duration trials involve many stakeholders, especially the patients and their family members, who have demonstrated their commitment to developing new therapeutic interventions for this devastating disease. We certainly do not want to lose all the knowledge we have gained from these ongoing trials because of the pandemic. While some of these trials will need to restart, others can re-start at different points along the trial protocol with substantial protocol amendments. However, there is an urgent need to combine useful information from the completers with those subjects undergoing complex protocols deviations and amendments after re-start. We propose the concept of mechanistic modeling-based virtual twin patients as a possible solution to harmonize the readouts from these complex and fragmented clinical datasets in a biologically relevant way.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32468710
    Database COVID19

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