Article: Pivotal advances: high-mobility group box 1 protein--a cytokine with a role in cardiac repair.
2007 Volume 81, Issue 1, Page(s) 41–45
Abstract: The nuclear protein high-mobility group box 1 (HMGB1) has been largely characterized for its role ... results in the improvement of cardiac function. In this review, we highlight the beneficial role of HMGB1 ... as a signal of tissue damage and participate in tissue repair by recruiting stem cells to the injury site ...
| Abstract | The nuclear protein high-mobility group box 1 (HMGB1) has been largely characterized for its role in inflammation. However, HMGB1 released by inflammatory cells, as well as by necrotic cells, may also act as a signal of tissue damage and participate in tissue repair by recruiting stem cells to the injury site. The emergence of this function has focused the interest on HMGB1 as a molecule with an active role in tissue regeneration. We recently demonstrated that HMGB1 administration in a mouse model of myocardial infarction activates cardiac stem cells and promotes their differentiation into cardiomyocytes. The regenerative effect results in the improvement of cardiac function. In this review, we highlight the beneficial role of HMGB1 and discuss growth factor-based therapeutic approaches for the treatment of myocardial infarction. |
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| MeSH term(s) | Animals ; Bone Marrow Cells/drug effects ; Cell Differentiation ; Cytokines/pharmacology ; Disease Models, Animal ; Dogs ; HMGB1 Protein/pharmacology ; Mice ; Myocardial Infarction/drug therapy ; Myocardial Infarction/prevention & control ; Myocardium/cytology ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/physiology ; Regeneration/drug effects ; Signal Transduction ; Stem Cells/drug effects ; Stem Cells/physiology |
| Chemical Substances | Cytokines ; HMGB1 Protein |
| Language | English |
| Publishing date | 2007-01 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 605722-6 |
| ISSN | 1938-3673 ; 0741-5400 |
| ISSN (online) | 1938-3673 |
| ISSN | 0741-5400 |
| DOI | 10.1189/jlb.0306165 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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