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  1. Article ; Online: Coronavirus Disease 2019 in Autoimmune Hepatitis: A Lesson From Immunosuppressed Patients.

    Gerussi, Alessio / Rigamonti, Cristina / Elia, Chiara / Cazzagon, Nora / Floreani, Annarosa / Pozzi, Roberta / Pozzoni, Pietro / Claar, Ernesto / Pasulo, Luisa / Fagiuoli, Stefano / Cristoferi, Laura / Carbone, Marco / Invernizzi, Pietro

    Hepatology communications

    2020  Volume 4, Issue 9, Page(s) 1257–1262

    Abstract: ... with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy ... coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients ... Our study is a case series of patients with AIH treated with immunosuppression, who tested positive for SARS ...

    Abstract Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy. Our study is a case series of patients with AIH treated with immunosuppression, who tested positive for SARS-CoV-2 in March 2020 during the outbreak of COVID-19. Ten patients from seven different hospitals in Italy were diagnosed with COVID-19 during the outbreak of SARS-CoV-2 in March 2020. Seven subjects were female (70%), and age ranged from 27 to 73 years. Before the onset of SARS-CoV-2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and consequently started high-dose steroids, as per induction protocol. All patients had a respiratory syndrome and a positive nasal swab for SARS-CoV-2. Five patients developed a computed tomography-confirmed COVID-19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients, the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS-CoV-2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high-dose steroids. The clinical outcome was comparable to the reported cases occurring in non-immunosuppressed subjects.
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Journal Article
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis: a lesson from immunosuppressed patients

    Gerussi, Alessio / Rigamonti, Cristina / Elia, Chiara / Cazzagon, Nora / Floreani, Annarosa / Pozzi, Roberta / Pozzoni, Pietro / Claar, Ernesto / Pasulo, Luisa / Fagiuoli, Stefano / Cristoferi, Laura / Carbone, Marco / Invernizzi, Pietro

    Abstract: ... of immunosuppressed autoimmune hepatitis (AIH) patients during coronavirus disease 2019 (COVID-19) infection in Italy ... Methods: Our study is a case series of AIH patients treated with immunosuppression, who tested positive ... all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission ...

    Abstract Background & Aims: Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of immunosuppressed autoimmune hepatitis (AIH) patients during coronavirus disease 2019 (COVID-19) infection in Italy. Methods: Our study is a case series of AIH patients treated with immunosuppression, who tested positive for SARS-CoV-2 in March 2020 during outbreak of COVID-19. Results: Ten patients from six different hospitals in Italy were diagnosed with COVID-19 during the outbreak of SARS-CoV-2 in March 2020. Seven subjects were female (70%) and age ranged from 27 to 73 years. Before the onset of SARS-CoV-2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and were consequently started high-dose steroids, as per induction protocol. All patients had a respiratory syndrome and had a positive nasal swab for SARS-CoV-2. Five patients developed a CT-confirmed COVID-19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS-CoV-2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high-dose steroids. The clinical outcome was comparable to the reported cases occurring in non-immunosuppressed subjects. Conclusion: Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively similar to that reported in non-immunosuppressed population. These data might help medical decision when dealing with SARS-CoV-2 infection in immunocompromised patients.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #591843
    Database COVID19

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  3. Article ; Online: Coronavirus Disease 2019 in Autoimmune Hepatitis

    Alessio Gerussi / Cristina Rigamonti / Chiara Elia / Nora Cazzagon / Annarosa Floreani / Roberta Pozzi / Pietro Pozzoni / Ernesto Claar / Luisa Pasulo / Stefano Fagiuoli / Laura Cristoferi / Marco Carbone / Pietro Invernizzi

    Hepatology Communications, Vol 4, Iss 9, Pp 1257-

    A Lesson From Immunosuppressed Patients

    2020  Volume 1262

    Abstract: ... with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID‐19) infection in Italy ... Patients under immunosuppressive therapy for AIH developing COVID‐19 show a disease course presumptively ... coronavirus 2 (SARS‐CoV‐2) infection. Our aim was to describe the clinical course of patients ...

    Abstract Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Our aim was to describe the clinical course of patients with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID‐19) infection in Italy. Our study is a case series of patients with AIH treated with immunosuppression, who tested positive for SARS‐CoV‐2 in March 2020 during the outbreak of COVID‐19. Ten patients from seven different hospitals in Italy were diagnosed with COVID‐19 during the outbreak of SARS‐CoV‐2 in March 2020. Seven subjects were female (70%), and age ranged from 27 to 73 years. Before the onset of SARS‐CoV‐2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and consequently started high‐dose steroids, as per induction protocol. All patients had a respiratory syndrome and a positive nasal swab for SARS‐CoV‐2. Five patients developed a computed tomography–confirmed COVID‐19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients, the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS‐CoV‐2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high‐dose steroids. The clinical outcome was comparable to the reported cases occurring in non‐immunosuppressed subjects. Conclusion: Patients under immunosuppressive therapy for AIH developing COVID‐19 show a disease course presumptively similar to that reported in the non‐immunosuppressed population. These data might aid in medical decisions when dealing with SARS‐CoV‐2 infection in immunocompromised patients.
    Keywords Diseases of the digestive system. Gastroenterology ; RC799-869 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis

    Gerussi, Alessio / Rigamonti, Cristina / Elia, Chiara / Cazzagon, Nora / Floreani, Annarosa / Pozzi, Roberta / Pozzoni, Pietro / Claar, Ernesto / Pasulo, Luisa / Fagiuoli, Stefano / Cristoferi, Laura / Carbone, Marco / Invernizzi, Pietro

    a lesson from immunosuppressed patients

    2020  

    Abstract: ... with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy ... Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively ... coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients ...

    Abstract Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy. Our study is a case series of patients with AIH treated with immunosuppression, who tested positive for SARS-CoV-2 in March 2020 during the outbreak of COVID-19. Ten patients from seven different hospitals in Italy were diagnosed with COVID-19 during the outbreak of SARS-CoV-2 in March 2020. Seven subjects were female (70%), and age ranged from 27 to 73 years. Before the onset of SARS-CoV-2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and consequently started high-dose steroids, as per induction protocol. All patients had a respiratory syndrome and a positive nasal swab for SARS-CoV-2. Five patients developed a computed tomography-confirmed COVID-19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients, the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS-CoV-2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high-dose steroids. The clinical outcome was comparable to the reported cases occurring in non-immunosuppressed subjects.Conclusion:Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively similar to that reported in the non-immunosuppressed population. These data might aid in medical decisions when dealing with SARS-CoV-2 infection in immunocompromised patients.
    Keywords autoimmunity ; cirrhosis ; liver ; severe acute respiratory syndrome coronavirus 2 ; viral infections ; covid19
    Subject code 610
    Language English
    Publisher JOHN WILEY & SONS LTD
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  5. Article ; Online: Coronavirus Disease 2019 (COVID-19) in autoimmune hepatitis

    Gerussi, A / Rigamonti, C / Elia, C / Cazzagon, N / Floreani, A / Pozzi, R / Pozzoni, P / Claar, E / Pasulo, L / Fagiuoli, S / Cristoferi, L / Carbone, M / Invernizzi, P

    a lesson from immunosuppressed patients

    2020  

    Abstract: ... with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy ... Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively ... coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients ...

    Abstract Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our aim was to describe the clinical course of patients with immunosuppressed autoimmune hepatitis (AIH) during coronavirus disease 2019 (COVID-19) infection in Italy. Our study is a case series of patients with AIH treated with immunosuppression, who tested positive for SARS-CoV-2 in March 2020 during the outbreak of COVID-19. Ten patients from seven different hospitals in Italy were diagnosed with COVID-19 during the outbreak of SARS-CoV-2 in March 2020. Seven subjects were female (70%), and age ranged from 27 to 73 years. Before the onset of SARS-CoV-2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and consequently started high-dose steroids, as per induction protocol. All patients had a respiratory syndrome and a positive nasal swab for SARS-CoV-2. Five patients developed a computed tomography-confirmed COVID-19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients, the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS-CoV-2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high-dose steroids. The clinical outcome was comparable to the reported cases occurring in non-immunosuppressed subjects.Conclusion:Patients under immunosuppressive therapy for AIH developing COVID-19 show a disease course presumptively similar to that reported in the non-immunosuppressed population. These data might aid in medical decisions when dealing with SARS-CoV-2 infection in immunocompromised patients.
    Keywords autoimmunity ; cirrhosis ; liver ; severe acute respiratory syndrome coronavirus 2 ; viral infections ; MED/12 - GASTROENTEROLOGIA ; MED/09 - MEDICINA INTERNA ; covid19
    Subject code 610
    Language English
    Publisher JOHN WILEY & SONS LTD
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Coronavirus Disease 2019 (COVID‐19) in autoimmune hepatitis

    Gerussi, Alessio / Rigamonti, Cristina / Elia, Chiara / Cazzagon, Nora / Floreani, Annarosa / Pozzi, Roberta / Pozzoni, Pietro / Claar, Ernesto / Pasulo, Luisa / Fagiuoli, Stefano / Cristoferi, Laura / Carbone, Marco / Invernizzi, Pietro

    a lesson from immunosuppressed patients

    2020  

    Abstract: ... of immunosuppressed autoimmune hepatitis (AIH) patients during coronavirus disease 2019 (COVID‐19) infection in Italy ... Patients under immunosuppressive therapy for AIH developing COVID‐19 show a disease course presumptively ... Methods Our study is a case series of AIH patients treated with immunosuppression, who tested positive ...

    Abstract Background & Aims Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Our aim was to describe the clinical course of immunosuppressed autoimmune hepatitis (AIH) patients during coronavirus disease 2019 (COVID‐19) infection in Italy. Methods Our study is a case series of AIH patients treated with immunosuppression, who tested positive for SARS‐CoV‐2 in March 2020 during outbreak of COVID‐19. Results Ten patients from six different hospitals in Italy were diagnosed with COVID‐19 during the outbreak of SARS‐CoV‐2 in March 2020. Seven subjects were female (70%) and age ranged from 27 to 73 years. Before the onset of SARS‐CoV‐2 infection, all patients were taking immunosuppressive therapy for AIH, and eight of them were on biochemical remission. Two other patients had recent acute onset of their AIH, and were consequently started high‐dose steroids, as per induction protocol. All patients had a respiratory syndrome and had a positive nasal swab for SARS‐CoV‐2. Five patients developed a CT‐confirmed COVID‐19 pneumonia. Six subjects received a combination of antiretroviral and antimalarial drugs. In seven patients the dosage of immunosuppressive medication was changed. Liver enzymes were repeated during SARS‐CoV‐2 infection in all hospitalized cases; they remained within the normal range in all cases, and improved in the two acute cases treated with high‐dose steroids. The clinical outcome was comparable to the reported cases occurring in non‐immunosuppressed subjects. Conclusion Patients under immunosuppressive therapy for AIH developing COVID‐19 show a disease course presumptively similar to that reported in non‐immunosuppressed population. These data might help medical decision when dealing with SARS‐CoV‐2 infection in immunocompromised patients.
    Keywords covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China.

    Yang, Yongshi / Peng, Fujun / Wang, Runsheng / Yange, Ming / Guan, Kai / Jiang, Taijiao / Xu, Guogang / Sun, Jinlyu / Chang, Christopher

    Journal of autoimmunity

    2020  Volume 109, Page(s) 102434

    Abstract: ... chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years ... The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral ... the viral nucleic acids of the virus isolated from SARS-CoV-2 infected patients. Extreme quarantine measures ...

    Abstract The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those with an underlying chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years, following SARS in 2002-2003 and MERS in 2012. While human strains of Coronavirus are associated with about 15% of cases of the common cold, the SARS-CoV-2 may present with varying degrees of severity, from flu-like symptoms to death. It is currently believed that this deadly Coronavirus strain originated from wild animals at the Huanan market in Wuhan, a city in Hubei province. Bats, snakes and pangolins have been cited as potential carriers based on the sequence homology of CoV isolated from these animals and the viral nucleic acids of the virus isolated from SARS-CoV-2 infected patients. Extreme quarantine measures, including sealing off large cities, closing borders and confining people to their homes, were instituted in January 2020 to prevent spread of the virus, but by that time much of the damage had been done, as human-human transmission became evident. While these quarantine measures are necessary and have prevented a historical disaster along the lines of the Spanish flu, earlier recognition and earlier implementation of quarantine measures may have been even more effective. Lessons learned from SARS resulted in faster determination of the nucleic acid sequence and a more robust quarantine strategy. However, it is clear that finding an effective antiviral and developing a vaccine are still significant challenges. The costs of the epidemic are not limited to medical aspects, as the virus has led to significant sociological, psychological and economic effects globally. Unfortunately, emergence of SARS-CoV-2 has led to numerous reports of Asians being subjected to racist behavior and hate crimes across the world.
    MeSH term(s) Animals ; Betacoronavirus/genetics ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; China/epidemiology ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/economics ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Genome, Viral ; History, 21st Century ; Humans ; Information Dissemination ; Pandemics/economics ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/economics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pyroptosis ; Quarantine ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/history ; Severe Acute Respiratory Syndrome/prevention & control ; Zoonoses/virology ; COVID-19 Drug Treatment
    Keywords covid19
    Language English
    Publishing date 2020-03-03
    Publishing country England
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639452-8
    ISSN 1095-9157 ; 0896-8411
    ISSN (online) 1095-9157
    ISSN 0896-8411
    DOI 10.1016/j.jaut.2020.102434
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  8. Article: The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China

    Yang, Yongshi / Peng, Fujun / Wang, Runsheng / Yange, Ming / Guan, Kai / Jiang, Taijiao / Xu, Guogang / Sun, Jinlyu / Chang, Christopher

    J Autoimmun

    Abstract: ... chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years ... The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral ... the viral nucleic acids of the virus isolated from SARS-CoV-2 infected patients. Extreme quarantine measures ...

    Abstract The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those with an underlying chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years, following SARS in 2002-2003 and MERS in 2012. While human strains of Coronavirus are associated with about 15% of cases of the common cold, the SARS-CoV-2 may present with varying degrees of severity, from flu-like symptoms to death. It is currently believed that this deadly Coronavirus strain originated from wild animals at the Huanan market in Wuhan, a city in Hubei province. Bats, snakes and pangolins have been cited as potential carriers based on the sequence homology of CoV isolated from these animals and the viral nucleic acids of the virus isolated from SARS-CoV-2 infected patients. Extreme quarantine measures, including sealing off large cities, closing borders and confining people to their homes, were instituted in January 2020 to prevent spread of the virus, but by that time much of the damage had been done, as human-human transmission became evident. While these quarantine measures are necessary and have prevented a historical disaster along the lines of the Spanish flu, earlier recognition and earlier implementation of quarantine measures may have been even more effective. Lessons learned from SARS resulted in faster determination of the nucleic acid sequence and a more robust quarantine strategy. However, it is clear that finding an effective antiviral and developing a vaccine are still significant challenges. The costs of the epidemic are not limited to medical aspects, as the virus has led to significant sociological, psychological and economic effects globally. Unfortunately, emergence of SARS-CoV-2 has led to numerous reports of Asians being subjected to racist behavior and hate crimes across the world.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #4387
    Database COVID19

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