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  1. Article: Diagnostic Utility of a Ferritin-to-Procalcitonin Ratio to Differentiate Patients With COVID-19 From Those With Bacterial Pneumonia: A Multicenter Study.

    Gharamti, Amal A / Mei, Fei / Jankousky, Katherine C / Huang, Jin / Hyson, Peter / Chastain, Daniel B / Fan, Jiawei / Osae, Sharmon / Zhang, Wayne W / Montoya, José G / Erlandson, Kristine M / Scherger, Sias J / Franco-Paredes, Carlos / Henao-Martínez, Andrés F / Shapiro, Leland

    Open forum infectious diseases

    2021  Volume 8, Issue 6, Page(s) ofab124

    Abstract: ... to-procalcitonin (F/P) ratio to classify pneumonia cases into those due to COVID-19 vs those due to bacterial ... that can differentiate coronavirus disease 2019 (COVID-19) from bacterial pneumonia. We assess the role of the ferritin ... pathogens.: Methods: This multicenter case-control study compared patients with COVID-19 ...

    Abstract Background: There is an urgent need for accurate, rapid, inexpensive biomarkers that can differentiate coronavirus disease 2019 (COVID-19) from bacterial pneumonia. We assess the role of the ferritin-to-procalcitonin (F/P) ratio to classify pneumonia cases into those due to COVID-19 vs those due to bacterial pathogens.
    Methods: This multicenter case-control study compared patients with COVID-19 with those with bacterial pneumonia, admitted between March 1 and May 31, 2020. Patients with COVID-19 and bacterial pneumonia co-infection were excluded. The F/P in patients with COVID-19 vs with bacterial pneumonia were compared. Receiver operating characteristic curve analysis determined the sensitivity and specificity of various cutoff F/P values for COVID-19 vs bacterial pneumonia.
    Results: A total of 242 COVID-19 pneumonia cases and 34 bacterial pneumonia controls were included. Patients with COVID-19 pneumonia had a lower mean age (57.1 vs 64.4 years;
    Conclusions: An F/P ≥877 increases the likelihood of COVID-19 pneumonia compared with bacterial pneumonia.
    Language English
    Publishing date 2021-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofab124
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study.

    Gharamti, Amal A / Mei, Fei / Jankousky, Katherine C / Huang, Jin / Hyson, Peter / Chastain, Daniel B / Fan, Jiawei / Osae, Sharmon / Zhang, Wayne W / Montoya, José G / Erlandson, Kristine M / Scherger, Sias J / Franco-Paredes, Carlos / Henao-Martínez, Andrés F / Shapiro, Leland

    medRxiv : the preprint server for health sciences

    2020  

    Abstract: ... if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia ... Design: This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted ... for the diagnosis of COVID-19 versus bacterial pneumonia.: Results: Patients with COVID-19 pneumonia had a lower ...

    Abstract Importance: There is a need to develop tools to differentiate COVID-19 from bacterial pneumonia at the time of clinical presentation before diagnostic testing is available.
    Objective: To determine if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia.
    Design: This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted between March 1 and May 31, 2020. Patients with COVID-19 and bacterial pneumonia co-infection were excluded.
    Setting: A multicenter study conducted at three hospitals that included UCHealth and Phoebe Putney Memorial Hospital in the United States, and Yichang Central People's Hospital in China.
    Participants: A total of 242 cases with COVID-19 infection and 34 controls with bacterial pneumonia.
    Main outcomes and measures: The F/P in patients with COVID-19 or with bacterial pneumonia were compared. Receiver operating characteristic analysis determined the sensitivity and specificity of various cut-off F/P values for the diagnosis of COVID-19 versus bacterial pneumonia.
    Results: Patients with COVID-19 pneumonia had a lower mean age (57.11 vs 64.4 years, p=0.02) and a higher BMI (30.74 vs 27.15 kg/m
    Conclusions and relevance: An F/P ≥ 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia. Further research is needed to determine if obtaining ferritin and procalcitonin simultaneously at the time of clinical presentation has improved diagnostic value. Additional questions include whether an increased F/P and/or serial F/P associates with COVID-19 disease severity or outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.10.20.20216309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study

    Gharamti, A. A. / Mei, F. / Jankousky, K. C. / Huang, J. / Hyson, P. / Chastain, D. B. / Fan, J. / Osae, S. / Zhang, W. W. / Montoya, J. G. / Erlandson, K. M. / Scherger, S. J. / Franco-Paredes, C. / Henao-Martinez, A. F. / Shapiro, L.

    MedRxiv : the Preprint Server for Health Sciences

    Abstract: ... if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia Design ... This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted between March 1 and May 31 ... bacterial pneumonia Results: Patients with COVID-19 pneumonia had a lower mean age (57 11 vs 64 4 years, p=0 02) and ...

    Abstract Importance: There is a need to develop tools to differentiate COVID-19 from bacterial pneumonia at the time of clinical presentation before diagnostic testing is available Objective: To determine if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia Design: This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted between March 1 and May 31, 2020 Patients with COVID-19 and bacterial pneumonia co-infection were excluded Setting: A multicenter study conducted at three hospitals that included UCHealth and Phoebe Putney Memorial Hospital in the United States, and Yichang Central People's Hospital in China Participants: A total of 242 cases with COVID-19 infection and 34 controls with bacterial pneumonia Main Outcomes and Measures: The F/P in patients with COVID-19 or with bacterial pneumonia were compared Receiver operating characteristic analysis determined the sensitivity and specificity of various cut-off F/P values for the diagnosis of COVID-19 versus bacterial pneumonia Results: Patients with COVID-19 pneumonia had a lower mean age (57 11 vs 64 4 years, p=0 02) and a higher BMI (30 74 vs 27 15 kg/m 2 , p=0 02) compared to patients with bacterial pneumonia Cases and controls had a similar proportion of women (47% vs 53%, p=0 5) and COVID-19 patients had a higher prevalence of diabetes mellitus (32 6% vs 12%, p=0 01) The median F/P was significantly higher in patients with COVID-19 (4037 5) compared to the F/P in bacterial pneumonia (802, p= 877 used to diagnose COVID-19 resulted in a sensitivity of 85% and a specificity of 56%, with a positive predictive value of 93 2%, and a likelihood ratio of 1 92 In multivariable analyses, an F/P >= 877 was associated with greater odds of identifying a COVID-19 case (OR: 11 27, CI: 4-31 2, p= 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia Further research is needed to determine if obtaining ferritin and procalcitonin simultaneously at the time of clinical presentation has improved diagnostic value Additional questions include whether an increased F/P and/or serial F/P associates with COVID-19 disease severity or outcomes
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #900767
    Database COVID19

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Diagnostic utility of a Ferritin-to-Procalcitonin Ratio to differentiate patients with COVID-19 from those with Bacterial Pneumonia: A multicenter study

    Gharamti, Amal A. / Mei, Fei / Jankousky, Katherine C. / Huang, Jin / Hyson, Peter / Chastain, Daniel B. / Fan, Jiawei / Osae, Sharmon / Zhang, Wayne W. / Montoya, Jose G. / Erlandson, Kristine M. / Scherger, Sias J. / Franco-Paredes, Carlos / Henao-Martinez, Andres F. / Shapiro, Leland

    medRxiv

    Abstract: ... if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia ... Design: This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted ... for the diagnosis of COVID-19 versus bacterial pneumonia. Results: Patients with COVID-19 pneumonia had a lower mean ...

    Abstract Importance: There is a need to develop tools to differentiate COVID-19 from bacterial pneumonia at the time of clinical presentation before diagnostic testing is available. Objective: To determine if the Ferritin-to-Procalcitonin ratio (F/P) can be used to differentiate COVID-19 from bacterial pneumonia. Design: This case-control study compared patients with either COVID-19 or bacterial pneumonia, admitted between March 1 and May 31, 2020. Patients with COVID-19 and bacterial pneumonia co-infection were excluded. Setting: A multicenter study conducted at three hospitals that included UCHealth and Phoebe Putney Memorial Hospital in the United States, and Yichang Central People Hospital in China. Participants: A total of 242 cases with COVID-19 infection and 34 controls with bacterial pneumonia. Main Outcomes and Measures: The F/P in patients with COVID-19 or with bacterial pneumonia were compared. Receiver operating characteristic analysis determined the sensitivity and specificity of various cut-off F/P values for the diagnosis of COVID-19 versus bacterial pneumonia. Results: Patients with COVID-19 pneumonia had a lower mean age (57.11 vs 64.4 years, p=0.02) and a higher BMI (30.74 vs 27.15 kg/m2, p=0.02) compared to patients with bacterial pneumonia. Cases and controls had a similar proportion of women (47% vs 53%, p=0.5) and COVID-19 patients had a higher prevalence of diabetes mellitus (32.6% vs 12%, p=0.01). The median F/P was significantly higher in patients with COVID-19 (4037.5) compared to the F/P in bacterial pneumonia (802, p<0.001). An F/P greater than or equal to 877 used to diagnose COVID-19 resulted in a sensitivity of 85% and a specificity of 56%, with a positive predictive value of 93.2%, and a likelihood ratio of 1.92. In multivariable analyses, an F/P greater than or equal to 877 was associated with greater odds of identifying a COVID-19 case (OR: 11.27, CI: 4-31.2, p<0.001). Conclusions and Relevance: An F/P greater than or equal to 877 increases the likelihood of COVID-19 pneumonia compared to bacterial pneumonia. Further research is needed to determine if obtaining ferritin and procalcitonin simultaneously at the time of clinical presentation has improved diagnostic value. Additional questions include whether an increased F/P and/or serial F/P associates with COVID-19 disease severity or outcomes.
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.10.20.20216309
    Database COVID19

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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