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  1. Article: Severe Acute Kidney Injury in Critically Ill Patients with COVID-19 Admitted to ICU: Incidence, Risk Factors, and Outcomes.

    Ghosn, Muriel / Attallah, Nizar / Badr, Mohamed / Abdallah, Khaled / De Oliveira, Bruno / Nadeem, Ashraf / Varghese, Yeldho / Munde, Dnyaseshwar / Salam, Shameen / Abduljawad, Baraa / Saleh, Khaled / Elkambergy, Hussam / Wahla, Ali / Taha, Ahmed / Dibu, Jamil / Bayrlee, Ahmed / Hamed, Fadi / Rahman, Nadeem / Mallat, Jihad

    Journal of clinical medicine

    2021  Volume 10, Issue 6

    Abstract: Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury ... AKI in critically ill patients with COVID-19 admitted to the intensive care unit (ICU) for acute ... in critically ill patients with COVID-19 and was not associated with inflammatory or thrombotic markers. Severe AKI ...

    Abstract Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury (AKI), defined as KDIGO (Kidney Disease Improving Global Outcomes) stages 2 or 3. However, data are limited in these patients. We aimed to report the incidence, risk factors, and prognostic impact of severe AKI in critically ill patients with COVID-19 admitted to the intensive care unit (ICU) for acute respiratory failure.
    Methods: A retrospective monocenter study including adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection admitted to the ICU for acute respiratory failure. The primary outcome was to identify the incidence and risk factors associated with severe AKI (KDIGO stages 2 or 3).
    Results: Overall, 110 COVID-19 patients were admitted. Among them, 77 (70%) required invasive mechanical ventilation (IMV), 66 (60%) received vasopressor support, and 9 (8.2%) needed extracorporeal membrane oxygenation (ECMO). Severe AKI occurred in 50 patients (45.4%). In multivariable logistic regression analysis, severe AKI was independently associated with age (odds ratio (OR) = 1.08 (95% CI (confidence interval): 1.03-1.14),
    Conclusion: Severe AKI was common in critically ill patients with COVID-19 and was not associated with inflammatory or thrombotic markers. Severe AKI was an independent risk factor of hospital mortality and hospital length of stay, and it should be rapidly recognized during SARS-CoV-2 infection.
    Language English
    Publishing date 2021-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10061217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of acute kidney injury in adult patients with severe COVID-19.

    Contrera Rolón, Nicolás / Varela, Carlos F / Ferraris, Augusto / Rojano, Adriana / Carboni Bisso, Indalecio / Greloni, Gustavo / Bratti, Griselda I / San Román, Juan E / Las Heras, Marcos / Sinner, Jorge F / Rosa Diez, Guillermo J

    Medicina

    2022  Volume 82, Issue 2, Page(s) 172–180

    Abstract: ... outcomes of patients with severe COVID-19 with acute kidney injury (AKI). One-hundred and sixtytwo ... In conclusion, AKI is frequent among critically ill patients with severe COVID-19 and it is associated ... intensive care unit (ICU) admitted patients in a tertiary level hospital in the city of Buenos Aires with COVID-19 ...

    Title translation Características de la injuria renal aguda en pacientes adultos con COVID-19 grave.
    Abstract We conducted a retrospective cohort study to report the clinical characteristics, incidence and outcomes of patients with severe COVID-19 with acute kidney injury (AKI). One-hundred and sixtytwo intensive care unit (ICU) admitted patients in a tertiary level hospital in the city of Buenos Aires with COVID-19 diagnosis were included. We hypothesized that COVID-19 related AKI would develop in the period of more severe hypoxemia as an early event and late AKI would be more probably related to intensive care unit complications. For this purpose, we divided subjects into two groups: those with early AKI and late AKI, before and after day 14 from symptom onset, respectively. A stepwise multivariate analysis was conducted to find possible AKI predictors. AKI incidence was 43.2% (n = 70) of the total patients admitted into ICU with severe COVID-19, 11.1% (n = 18) required renal replacement therapy. In-hospital mortality was higher (58.6%) for the AKI group. AKI occurred on a median time of 10 (IQR 5.5-17.5) days from symptom onset. A history of hypertension or heart failure, age and invasive mechanical ventilation (IMV) requirement were identified as risk factors. Late AKI (n = 25, 35.7%) was associated with sepsis and nephrotoxic exposure, whereas early AKI occurred closer to the timing of IMV initiation and was more likely to have an unknown origin. In conclusion, AKI is frequent among critically ill patients with severe COVID-19 and it is associated with higher in-hospital mortality.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Adult ; COVID-19/complications ; COVID-19 Testing ; Female ; Humans ; Intensive Care Units ; Male ; Renal Replacement Therapy/adverse effects ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-04-13
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 411586-7
    ISSN 1669-9106 ; 0025-7680 ; 0325-951X
    ISSN (online) 1669-9106
    ISSN 0025-7680 ; 0325-951X
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 163: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Severe acute kidney injury in critically ill COVID-19 patients.

    Piñeiro, Gaston J / Molina-Andújar, Alicia / Hermida, Evelyn / Blasco, Miquel / Quintana, Luis F / Rojas, Guido Muñoz / Mercadal, Jordi / Castro, Pedro / Sandoval, Elena / Andrea, Rut / Fernández, Javier / Badia, Joan Ramon / Soriano, Alex / Poch, Esteban

    Journal of nephrology

    2021  Volume 34, Issue 2, Page(s) 285–293

    Abstract: ... patients. Factors associated with AKI in COVID-19 intensive care unit (ICU) patients and their outcomes ... 0.024).: Conclusions: The prevalence of moderate/severe AKI in COVID-19 patients admitted ... of moderate-severe AKI of COVID-19 patients in an ICU context. As a secondary goal, we aimed to find ...

    Abstract Background: Acute kidney injury (AKI) is frequent in Coronavirus Infection Disease 2019 (COVID-19) patients. Factors associated with AKI in COVID-19 intensive care unit (ICU) patients and their outcomes have not been previously explored.
    Methods: Prospective observational study of COVID-19 patients admitted to the ICUs of the Hospital Clínic of Barcelona (Spain), from March 25th to April 21st, 2020, who developed AKI stage 2 or higher (AKIN classification). The primary goal was to describe the characteristics of moderate-severe AKI of COVID-19 patients in an ICU context. As a secondary goal, we aimed to find independent predictors of AKI progression, Renal Replacement Therapy (RRT) requirement and mortality among these patients.
    Results: During the study period, 52 out of 237 ICU patients, developed AKIN stage 2 or higher and were included in the study. A Sequential Organ Failure Assessment (SOFA) score at AKI diagnosis of 8 or higher was associated with RRT, OR 5.2, p 0.032. At the time of AKI diagnosis, patients had a worse liver profile and higher inflammation markers than at admission. Fifty per cent of the patients presented AKI progression from AKIN 2 to 3 and 28.85% required RRT. The use of corticosteroids in 69.2% of patients was associated with a reduced requirement of RRT, OR 0.13 (CI 95% 0.02-0.89), p 0.037. AKI was associated with high mortality (50%) and a longer hospital stay, median 35 vs 18 days (p 0.024).
    Conclusions: The prevalence of moderate/severe AKI in COVID-19 patients admitted to the ICU is high and has a strong correlation with mortality and length of hospital stay.
    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Aged ; COVID-19/complications ; COVID-19/epidemiology ; Critical Illness ; Female ; Follow-Up Studies ; Hospital Mortality/trends ; Hospitalization/trends ; Humans ; Incidence ; Intensive Care Units/statistics & numerical data ; Male ; Pandemics ; Prospective Studies ; Renal Replacement Therapy/methods ; Risk Factors ; SARS-CoV-2 ; Spain/epidemiology
    Language English
    Publishing date 2021-01-02
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-020-00918-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Severe acute kidney injury in COVID-19 patients is associated with in-hospital mortality.

    Paek, Jin Hyuk / Kim, Yaerim / Park, Woo Yeong / Jin, Kyubok / Hyun, Miri / Lee, Ji Yeon / Kim, Hyun Ah / Kwon, Yong Shik / Park, Jae Seok / Han, Seungyeup

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243528

    Abstract: ... to identify the incidence of acute kidney injury (AKI) in patients with COVID-19 and to evaluate its impact ... on patient outcomes. This retrospective study included 704 patients with COVID-19 who were hospitalized ... that the cumulative survival rate was lowest in the AKI stage 3 group (p < 0.001). In conclusion, the incidence of AKI in patients ...

    Abstract Although the lungs are major targets for COVID-19 invasion, other organs-such as the kidneys-are also affected. However, the renal complications of COVID-19 are not yet well explored. This study aimed to identify the incidence of acute kidney injury (AKI) in patients with COVID-19 and to evaluate its impact on patient outcomes. This retrospective study included 704 patients with COVID-19 who were hospitalized at two hospitals in Daegu, Korea from February 19 to March 31, 2020. AKI was defined according to the serum creatinine criteria in the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The final date of follow-up was May 1, 2020. Of the 704 patients, 28 (4.0%) developed AKI. Of the 28 patients with AKI, 15 (53.6%) were found to have AKI stage 1, 3 (10.7%) had AKI stage 2, and 10 (35.7%) had AKI stage 3. Among these patients, 12 (42.9%) recovered from AKI. In the patients with AKI, the rates of admission to intensive care unit (ICU), administration of mechanical ventilator (MV), and in-hospital mortality were significantly higher than in patients without AKI. Multivariable analysis revealed that old age (Hazard ratio [HR] = 4.668, 95% confidence interval [CI] = 1.250-17.430, p = 0.022), high neutrophil-to-lymphocyte ratio (HR = 1.167, 95% CI = 1.078-1.264, p < 0.001), elevated creatinine kinase (HR = 1.002, 95% CI = 1.001-1.004, p = 0.007), and severe AKI (HR = 12.199, 95% CI = 4.235-35.141, p < 0.001) were independent risk factors for in-hospital mortality. The Kaplan-Meier curves showed that the cumulative survival rate was lowest in the AKI stage 3 group (p < 0.001). In conclusion, the incidence of AKI in patients with COVID-19 was 4.0%. Severe AKI was associated with in-hospital death.
    MeSH term(s) Acute Kidney Injury/blood ; Acute Kidney Injury/etiology ; Acute Kidney Injury/mortality ; Acute Kidney Injury/therapy ; Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Critical Care ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Patient Admission ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Survival Rate
    Language English
    Publishing date 2020-12-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0243528
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  5. Article ; Online: Severe Acute Kidney Injury in Critically Ill Patients with COVID-19 Admitted to ICU

    Muriel Ghosn / Nizar Attallah / Mohamed Badr / Khaled Abdallah / Bruno De Oliveira / Ashraf Nadeem / Yeldho Varghese / Dnyaseshwar Munde / Shameen Salam / Baraa Abduljawad / Khaled Saleh / Hussam Elkambergy / Ali Wahla / Ahmed Taha / Jamil Dibu / Ahmed Bayrlee / Fadi Hamed / Nadeem Rahman / Jihad Mallat

    Journal of Clinical Medicine, Vol 10, Iss 1217, p

    Incidence, Risk Factors, and Outcomes

    2021  Volume 1217

    Abstract: Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury ... AKI in critically ill patients with COVID-19 admitted to the intensive care unit (ICU) for acute ... common in critically ill patients with COVID-19 and was not associated with ... ...

    Abstract Background: Critically ill patients with COVID-19 are prone to develop severe acute kidney injury (AKI), defined as KDIGO (Kidney Disease Improving Global Outcomes) stages 2 or 3. However, data are limited in these patients. We aimed to report the incidence, risk factors, and prognostic impact of severe AKI in critically ill patients with COVID-19 admitted to the intensive care unit (ICU) for acute respiratory failure. Methods: A retrospective monocenter study including adult patients with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection admitted to the ICU for acute respiratory failure. The primary outcome was to identify the incidence and risk factors associated with severe AKI (KDIGO stages 2 or 3). Results: Overall, 110 COVID-19 patients were admitted. Among them, 77 (70%) required invasive mechanical ventilation (IMV), 66 (60%) received vasopressor support, and 9 (8.2%) needed extracorporeal membrane oxygenation (ECMO). Severe AKI occurred in 50 patients (45.4%). In multivariable logistic regression analysis, severe AKI was independently associated with age (odds ratio (OR) = 1.08 (95% CI (confidence interval): 1.03–1.14), p = 0.003), IMV (OR = 33.44 (95% CI: 2.20–507.77), p = 0.011), creatinine level on admission (OR = 1.04 (95% CI: 1.008–1.065), p = 0.012), and ECMO (OR = 11.42 (95% CI: 1.95–66.70), p = 0.007). Inflammatory (interleukin-6, C-reactive protein, and ferritin) or thrombotic (D-dimer and fibrinogen) markers were not associated with severe AKI after adjustment for potential confounders. Severe AKI was independently associated with hospital mortality (OR = 29.73 (95% CI: 4.10–215.77), p = 0.001) and longer hospital length of stay (subhazard ratio = 0.26 (95% CI: 0.14–0.51), p < 0.001). At the time of hospital discharge, 74.1% of patients with severe AKI who were discharged alive from the hospital recovered normal or baseline renal function. Conclusion: Severe AKI was common in critically ill patients with COVID-19 and was not associated with ...
    Keywords acute kidney injury ; COVID-19 ; critically ill ; interleukin-6 ; D-dimer ; mechanical ventilation ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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