Article ; Online: Polycations and polyanions in SARS-CoV-2 infection.
2021 Volume 146, Page(s) 110470
Abstract: ... These effects may be alleviated by the administration of negatively charged polyanions such as heparins and ... the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus ... with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system ...
| Abstract | We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids. |
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| MeSH term(s) | Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/etiology ; COVID-19/metabolism ; Endocytosis ; Heparin/therapeutic use ; Histones/metabolism ; Humans ; Immunity, Innate ; Models, Biological ; Neutrophils/metabolism ; Pandemics ; Polyelectrolytes/metabolism ; Polyelectrolytes/therapeutic use ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Static Electricity ; Virus Internalization | |||||
| Chemical Substances | Antiviral Agents ; Histones ; Polyelectrolytes ; polyanions ; polycations ; Heparin (9005-49-6) | |||||
| Language | English | |||||
| Publishing date | 2021-01-04 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 193145-3 | |||||
| ISSN | 1532-2777 ; 0306-9877 | |||||
| ISSN (online) | 1532-2777 | |||||
| ISSN | 0306-9877 | |||||
| DOI | 10.1016/j.mehy.2020.110470 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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