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  1. Article ; Online: Computational Forecasting Methodology for Acute Respiratory Infectious Disease Dynamics.

    Gónzalez-Bandala, Daniel Alejandro / Cuevas-Tello, Juan Carlos / Noyola, Daniel E / Comas-García, Andreu / García-Sepúlveda, Christian A

    International journal of environmental research and public health

    2020  Volume 17, Issue 12

    Abstract: ... channel calculation. The predictions are made on weekly acute respiratory infection (ARI) data obtained ... to limit the spread of an epidemic. We propose a methodology that merges the predictions ... The study of infectious disease behavior has been a scientific concern for many years as early ...

    Abstract The study of infectious disease behavior has been a scientific concern for many years as early identification of outbreaks provides great advantages including timely implementation of public health measures to limit the spread of an epidemic. We propose a methodology that merges the predictions of (i) a computational model with machine learning, (ii) a projection model, and (iii) a proposed smoothed endemic channel calculation. The predictions are made on weekly acute respiratory infection (ARI) data obtained from epidemiological reports in Mexico, along with the usage of key terms in the Google search engine. The results obtained with this methodology were compared with state-of-the-art techniques resulting in reduced root mean squared percentage error (RMPSE) and maximum absolute percent error (MAPE) metrics, achieving a MAPE of 21.7%. This methodology could be extended to detect and raise alerts on possible outbreaks on ARI as well as for other seasonal infectious diseases.
    MeSH term(s) Communicable Diseases ; Disease Outbreaks ; Epidemics ; Forecasting ; Humans ; Mexico ; Respiratory Tract Diseases/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-06-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17124540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Computational Forecasting Methodology for Acute Respiratory Infectious Disease Dynamics

    Daniel Alejandro Gónzalez-Bandala / Juan Carlos Cuevas-Tello / Daniel E. Noyola / Andreu Comas-García / Christian A. García-Sepúlveda

    International Journal of Environmental Research and Public Health, Vol 17, Iss 4540, p

    2020  Volume 4540

    Abstract: ... channel calculation. The predictions are made on weekly acute respiratory infection (ARI) data obtained ... to limit the spread of an epidemic. We propose a methodology that merges the predictions ... The study of infectious disease behavior has been a scientific concern for many years as early ...

    Abstract The study of infectious disease behavior has been a scientific concern for many years as early identification of outbreaks provides great advantages including timely implementation of public health measures to limit the spread of an epidemic. We propose a methodology that merges the predictions of (i) a computational model with machine learning, (ii) a projection model, and (iii) a proposed smoothed endemic channel calculation. The predictions are made on weekly acute respiratory infection (ARI) data obtained from epidemiological reports in Mexico, along with the usage of key terms in the Google search engine. The results obtained with this methodology were compared with state-of-the-art techniques resulting in reduced root mean squared percentage error (RMPSE) and maximum absolute percent error (MAPE) metrics, achieving a MAPE of 21.7%. This methodology could be extended to detect and raise alerts on possible outbreaks on ARI as well as for other seasonal infectious diseases.
    Keywords bioinformatics ; epidemics ; data science ; artificial intelligence ; pattern recognition ; forecasting ; Medicine ; R
    Subject code 006
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Design of Potential RNAi (miRNA and siRNA) Molecules for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Gene Silencing by Computational Method.

    Nur, Suza Mohammad / Hasan, Md Anayet / Amin, Mohammad Al / Hossain, Mehjabeen / Sharmin, Tahmina

    Interdisciplinary sciences, computational life sciences

    2015  Volume 7, Issue 3, Page(s) 257–265

    Abstract: ... itself in viral infection with fever, cough, shortness of breath, renal failure and severe acute pneumonia, which often ... for disease control. Viral activity can be controlled by RNA interference (RNAi) technology, a leading method ... designed and corroborated using computational methods, which might lead to knockdown the activity of virus ...

    Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) is a virus that manifests itself in viral infection with fever, cough, shortness of breath, renal failure and severe acute pneumonia, which often result in a fatal outcome. MERS-CoV has been shown to spread between people who are in close contact. Transmission from infected patients to healthcare personnel has also been observed and is irredeemable with present technology. Genetic studies on MERS-CoV have shown that ORF1ab encodes replicase polyproteins and play a foremost role in viral infection. Therefore, ORF1ab replicase polyprotein may be used as a suitable target for disease control. Viral activity can be controlled by RNA interference (RNAi) technology, a leading method for post transcriptional gene silencing in a sequence-specific manner. However, there is a genetic inconsistency in different viral isolates; it is a great challenge to design potential RNAi (miRNA and siRNA) molecules which can silence the respective target genes rather than any other viral gene simultaneously. In the current study, four effective miRNA and five siRNA molecules for silencing of nine different strains of MERS-CoV were rationally designed and corroborated using computational methods, which might lead to knockdown the activity of virus. siRNA and miRNA molecules were predicted against ORF1ab gene of different strains of MERS-CoV as effective candidate using computational methods. Thus, this method may provide an insight for the chemical synthesis of antiviral RNA molecule for the treatment of MERS-CoV, at genomic level.
    MeSH term(s) Algorithms ; Base Composition ; Base Sequence ; Computational Biology/methods ; Gene Silencing ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle East Respiratory Syndrome Coronavirus/genetics ; Nucleic Acid Conformation ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Thermodynamics
    Chemical Substances MicroRNAs ; RNA, Small Interfering
    Keywords covid19
    Language English
    Publishing date 2015-07-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2493085-4
    ISSN 1867-1462 ; 1913-2751
    ISSN (online) 1867-1462
    ISSN 1913-2751
    DOI 10.1007/s12539-015-0266-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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