Article ; Online: COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study.
2021 Volume 36, Issue 11, Page(s) 2094–2105
Abstract: Background: Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and ... recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved ... comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and ...
| Abstract | Background: Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics. Methods: Data on KT recipients and HD patients diagnosed with COVID-19 between 1 February 2020 and 1 December 2020 were retrieved from the European Renal Association COVID-19 Database. Cox regression models adjusted for age, sex, frailty and comorbidities were used to estimate hazard ratios (HRs) for 28-day mortality risk in all patients and in the subsets that were tested because of symptoms. Results: A total of 1670 patients (496 functional KT and 1174 HD) were included; 16.9% of KT and 23.9% of HD patients died within 28 days of presentation. The unadjusted 28-day mortality risk was 33% lower in KT recipients compared with HD patients {HR 0.67 [95% confidence interval (CI) 0.52-0.85]}. In a fully adjusted model, the risk was 78% higher in KT recipients [HR 1.78 (95% CI 1.22-2.61)] compared with HD patients. This association was similar in patients tested because of symptoms [fully adjusted model HR 2.00 (95% CI 1.31-3.06)]. This risk was dramatically increased during the first post-transplant year. Results were similar for other endpoints (e.g. hospitalization, intensive care unit admission and mortality >28 days) and across subgroups. Conclusions: KT recipients had a greater risk of a more severe course of COVID-19 compared with HD patients, therefore they require specific infection mitigation strategies. |
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| MeSH term(s) | COVID-19 ; Humans ; Kidney Failure, Chronic/therapy ; Kidney Transplantation/adverse effects ; Registries ; Renal Dialysis ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-06-16 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 90594-x | ||||||||||
| ISSN | 1460-2385 ; 0931-0509 | ||||||||||
| ISSN (online) | 1460-2385 | ||||||||||
| ISSN | 0931-0509 | ||||||||||
| DOI | 10.1093/ndt/gfab200 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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