Article ; Online: Post-thrombotic syndrome in children: a systematic review of frequency of occurrence, validity of outcome measures, and prognostic factors.
2010 Volume 95, Issue 11, Page(s) 1952–1959
Abstract: ... of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome.: Design ... Standardized post-thrombotic syndrome outcome measures included an adaptation of the Villalta scale ... of post-thrombotic syndrome was 26% (95% confidence interval: 23-28%) overall, and differed significantly ...
| Abstract | Background: Post-thrombotic syndrome is a manifestation of chronic venous insufficiency following deep venous thrombosis. This systematic review was conducted to critically evaluate pediatric evidence on frequency of occurrence, validity of outcome measures, and prognostic indicators of post-thrombotic syndrome. Design and methods: A comprehensive literature search of original reports revealed 19 eligible studies, totaling 977 patients with upper/lower extremity deep venous thrombosis. Calculated weighted mean frequency of post-thrombotic syndrome was 26% (95% confidence interval: 23-28%) overall, and differed significantly by prospective/non-prospective analysis and use/non-use of a standardized outcome measure. Results: Standardized post-thrombotic syndrome outcome measures included an adaptation of the Villalta scale, the Clinical-Etiologic-Anatomic-Pathologic classification, and the Manco-Johnson instrument. Data on validity were reported only for the Manco-Johnson instrument. No publications on post-thrombotic syndrome-related quality of life outcomes were identified. Candidate prognostic factors for post-thrombotic syndrome in prospective studies included use/non-use of thrombolysis and plasma levels of factor VIII activity and D-dimer. Conclusions: Given that affected children must endure chronic sequelae for many decades, it is imperative that future collaborative pediatric prospective cohort studies and trials assess as key objectives and outcomes the incidence, severity, prognostic indicators, and health impact of post-thrombotic syndrome, using validated measures. |
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| MeSH term(s) | Adolescent ; Child ; Child, Preschool ; Chronic Disease ; Clinical Trials as Topic ; Female ; Humans ; Male ; Postthrombotic Syndrome/epidemiology ; Postthrombotic Syndrome/etiology ; Postthrombotic Syndrome/therapy ; Quality of Life ; Venous Thrombosis/complications ; Venous Thrombosis/epidemiology ; Venous Thrombosis/therapy | |||||
| Language | English | |||||
| Publishing date | 2010-06-30 | |||||
| Publishing country | Italy | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review ; Systematic Review | |||||
| ZDB-ID | 2333-4 | |||||
| ISSN | 1592-8721 ; 0017-6567 ; 0390-6078 | |||||
| ISSN (online) | 1592-8721 | |||||
| ISSN | 0017-6567 ; 0390-6078 | |||||
| DOI | 10.3324/haematol.2010.026989 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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