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  1. Article ; Online: Improving Spatial Estimates for COVID-19 Using Surveillance Data in Philadelphia

    Goldstein, N.D. / Wheeler, D.C. / Gustafson, P. / Burstyn, I.

    Annals of Epidemiology ; ISSN 1047-2797

    2020  

    Keywords Epidemiology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.annepidem.2020.08.050
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Bayesian approach to improving spatial estimates of prevalence of COVID-19 after accounting for misclassification bias in surveillance data in Philadelphia, PA.

    Goldstein, Neal D / Wheeler, David C / Gustafson, Paul / Burstyn, Igor

    Spatial and spatio-temporal epidemiology

    2021  Volume 36, Page(s) 100401

    Abstract: Surveillance data obtained by public health agencies for COVID-19 are likely inaccurate due ... of prevalence of COVID-19 in Philadelphia, PA at the ZIP code level. After evaluating various modeling ... sensitivity and specificity from the models were similar, about 60% and more than 99%, respectively. Surveillance of COVID-19 ...

    Abstract Surveillance data obtained by public health agencies for COVID-19 are likely inaccurate due to undercounting and misdiagnosing. Using a Bayesian approach, we sought to reduce bias in the estimates of prevalence of COVID-19 in Philadelphia, PA at the ZIP code level. After evaluating various modeling approaches in a simulation study, we estimated true prevalence by ZIP code with and without conditioning on an area deprivation index (ADI). As of June 10, 2020, in Philadelphia, the observed citywide period prevalence was 1.5%. After accounting for bias in the surveillance data, the median posterior citywide true prevalence was 2.3% when accounting for ADI and 2.1% when not. Overall the median posterior surveillance sensitivity and specificity from the models were similar, about 60% and more than 99%, respectively. Surveillance of COVID-19 in Philadelphia tends to understate discrepancies in burden for the more affected areas, potentially misinforming mitigation priorities.
    MeSH term(s) Bayes Theorem ; Bias ; COVID-19/epidemiology ; Humans ; Philadelphia/epidemiology ; Population Surveillance ; Prevalence ; SARS-CoV-2 ; Sensitivity and Specificity ; Spatial Analysis
    Language English
    Publishing date 2021-01-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515896-X
    ISSN 1877-5853 ; 1877-5845
    ISSN (online) 1877-5853
    ISSN 1877-5845
    DOI 10.1016/j.sste.2021.100401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: A Bayesian Approach to Improving Spatial Estimates After Accounting for Misclassification Bias in Surveillance Data for COVID-19 in Philadelphia, PA

    Goldstein, Neal D / Wheeler, David C / Gustafson, Paul / Burstyn, Igor

    2020  

    Abstract: ... a Bayesian approach, we adjusted for misclassification to improve spatial estimation of COVID-19 in Philadelphia, PA ... Surveillance data obtained by public health agencies for COVID-19 are likely inaccurate. Using ... prevalence of 1.5%. After accounting for bias in the surveillance data, the posterior citywide true ...

    Abstract Surveillance data obtained by public health agencies for COVID-19 are likely inaccurate. Using a Bayesian approach, we adjusted for misclassification to improve spatial estimation of COVID-19 in Philadelphia, PA at the ZIP code level. We modeled true prevalence as a function of area deprivation index and spatial random effects at the ZIP code level. There were 111,497 documented tests as of June 10, 2020 in Philadelphia, among whom 23,941 (21%) were classified by the laboratory as positive for SARS-CoV-2, translating to an observed prevalence of 1.5%. After accounting for bias in the surveillance data, the posterior citywide true prevalence was 2.8% (95% credible interval: 2.7%, 3.0%). Overall the posterior surveillance sensitivity and specificity were 58.9% (95% credible interval: 41.5%, 75.9%) and 99.8% (95% credible interval: 99.7%, 100%), respectively. Underreporting tends to understate discrepancies in burden for more affected areas, potentially leading to bias in setting priorities.
    Keywords SARS-CoV-2 ; COVID-19 ; surveillance ; misclassification ; Bayesian analysis ; covid19
    Subject code 310
    Publishing date 2020-07-08
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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