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  1. Article ; Online: Clinical Characteristics and Prognosis of COPD Patients Hospitalized with SARS-CoV-2.

    Gómez Antúnez, María / Muiño Míguez, Antonio / Bendala Estrada, Alejandro David / Maestro de la Calle, Guillermo / Monge Monge, Daniel / Boixeda, Ramón / Ena, Javier / Mella Pérez, Carmen / Anton Santos, Juan Miguel / Lumbreras Bermejo, Carlos

    International journal of chronic obstructive pulmonary disease

    2021  Volume 15, Page(s) 3433–3445

    Abstract: ... with SARS-CoV-2 infection have more severe disease and a worse prognosis than non-COPD patients. ... Objective: To describe the characteristics and prognosis of patients with COPD admitted ... treatment, and progress are collected. Patients with COPD were selected and compared to patients ...

    Abstract Objective: To describe the characteristics and prognosis of patients with COPD admitted to the hospital due to SARS-CoV-2 infection.
    Methods: The SEMI-COVID registry is an ongoing retrospective cohort comprising consecutive COVID-19 patients hospitalized in Spain since the beginning of the pandemic in March 2020. Data on demographics, clinical characteristics, comorbidities, laboratory tests, radiology, treatment, and progress are collected. Patients with COPD were selected and compared to patients without COPD. Factors associated with a poor prognosis were analyzed.
    Results: Of the 10,420 patients included in the SEMI-COVID registry as of May 21, 2020, 746 (7.16%) had a diagnosis of COPD. Patients with COPD are older than those without COPD (77 years vs 68 years) and more frequently male. They have more comorbidities (hypertension, hyperlipidemia, diabetes mellitus, atrial fibrillation, heart failure, ischemic heart disease, peripheral vascular disease, kidney failure) and a higher Charlson Comorbidity Index (2 vs 1, p<0.001). The mortality rate in COPD patients was 38.3% compared to 19.2% in patients without COPD (p<0.001). Male sex, a history of hypertension, heart failure, moderate-severe chronic kidney disease, presence of cerebrovascular disease with sequelae, degenerative neurological disease, dementia, functional dependence, and a higher Charlson Comorbidity Index have been associated with increased mortality due to COVID-19 in COPD patients. Survival was higher among patients with COPD who were treated with hydroxychloroquine (87.1% vs 74.9%, p<0.001) and with macrolides (57.9% vs 50%, p<0.037). Neither prone positioning nor non-invasive mechanical ventilation, high-flow nasal cannula, or invasive mechanical ventilation were associated with a better prognosis.
    Conclusion: COPD patients admitted to the hospital with SARS-CoV-2 infection have more severe disease and a worse prognosis than non-COPD patients.
    MeSH term(s) Aged ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Prognosis ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/therapy ; Registries ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Spain/epidemiology ; Survival Rate
    Language English
    Publishing date 2021-01-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S276692
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  2. Article ; Online: The impact of the SARS-CoV-2 pandemic on the demographic, clinical and social profiles of patients admitted to the Pneumology Department for a COPD exacerbation.

    Fernández Villar, Alberto / Golpe Gómez, Rafael / González Montaos, Almudena / Fernández García, Sara / Pazos Area, Luis / Priegue Carrera, Ana / Ruano Raviña, Alberto / Represas Represas, Cristina

    PloS one

    2023  Volume 18, Issue 9, Page(s) e0290156

    Abstract: ... Demographic, clinical and social characteristics were compared among patients admitted for an AECOPD ... Introduction: Although a reduction in admissions for pathologies other than SARS-CoV-2 has been ... level vaccination, admissions for AECOPD were in patients with more severe disease and with a higher ...

    Abstract Introduction: Although a reduction in admissions for pathologies other than SARS-CoV-2 has been reported during the pandemic, there are hardly any specific studies in relation to COPD. The objective of this study was to analyse differences in the profile of those admitted for AEPOC and their prognosis during this period.
    Methods: Prospective study (SocioEPOC validation cohort) conducted in two hospitals. Demographic, clinical and social characteristics were compared among patients admitted for an AECOPD before and after the declaration of the COVID-19 healthcare emergency. Mortality and the need for hospital care in the following 3 months were analysed.
    Results: 340 patients (76.6% male, 72 years, FEV1 43.5%) were included, 174 in the post-pandemic phase. During pandemic, especially before population-level vaccination, admissions for AECOPD were in patients with more severe disease and with a higher level of eosinophils. No differences were found in social profile, except they had more informal caregivers. The mortality rate at 90 days was the same (9%), although those admitted during the pandemic came for more hospital visits in the following 3 months (53.8% vs. 42%; p = 0.003), with the pandemic phase being an independent predictor of this possibility (OR = 1.6.; 95% IC = 1.1-2.6).
    Conclusions: In the first few months of the pandemic, the clinical profile of patients hospitalised for an AECOPD differed from that both prior to this period and during the latter months of the pandemic, with minimal changes at the social level. Although the mortality rate were similar, unscheduled hospital visits increased during the COVID-19 pandemic.
    MeSH term(s) Humans ; Male ; Female ; SARS-CoV-2 ; Pandemics ; COVID-19/epidemiology ; Prospective Studies ; Pulmonary Medicine ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Demography
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0290156
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  3. Article: Clinical characteristics of severe coronavirus disease 2019 patients with chronic obstructive pulmonary disease.

    Liang, Huaying / Lu, Rongli / Li, Yi / Pan, Pinhua

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2023  Volume 47, Issue 12, Page(s) 1695–1703

    Abstract: ... and fatigue (40.9%). Compared with non-COPD patients, patients with COPD had significantly lower ... levels of platelet counts, albumin and apolipoprotein AI. Severe COVID-19 patients with COPD had higher ... We explore the epidemiological characteristics of patients with severe COVID-19 with COPD patients in order ...

    Title translation 重型新型冠状病毒肺炎合并慢性阻塞性肺疾病患者临床特征.
    Abstract Objectives: Coronavirus disease 2019 (COVID-19) in elderly and patients with chronic respiratory diseases (COPD) had a poor prognosis. COPD is one of the most common chronic respiratory diseases. We explore the epidemiological characteristics of patients with severe COVID-19 with COPD patients in order to provide medical evidence for the prevention and treatment of severe COVID-19.
    Methods: We retrospectively analyzed the clinical baseline characteristics, treatment strategies, disease progression and prognosis of 557 severe COVID-19 patients admitted to the West Court of Union Hospital of Huazhong University of Science and Technology from January 29, 2020 to April 8, 2020.
    Results: A total of 465 patients with severe COVID-19 were enrolled in the study, including 248 (53.3%) males and 217 (46.7%) females. The median age of severe COVID-19 patients was 62.0 years, and 53 patients were complicated with COPD. Common symptoms at the onset included fever (78.5%), dry cough (67.1%), shortness of breath (47.3%) and fatigue (40.9%). Compared with non-COPD patients, patients with COPD had significantly lower levels of SpO2 in admission (90.0% vs 92.0%, P=0.014). In terms of laboratory examinations, patients with COPD had higher levels of C-reactive protein, interleukin-6, procalcitonin, total bilirubin, blood urea nitrogen, serum creatinine, lipoprotein (a), high-sensitivity troponin I, and D-dimer, while had lower levels of platelet counts, albumin and apolipoprotein AI. Severe COVID-19 patients with COPD had higher Sequential Organ Failure Assessment scores [3.0(2.0, 3.0) vs 2.0(2.0, 3.0), P=0.038] and CURB-65 score [1.0(1.0, 2.0) vs1.0(0.0, 1.0), P<0.001], and a higher proportion of progressing to critical illness (28.3% vs 10.0%, P<0.001) with more complications [e.g. septic shock (15.1% vs 6.1%, P=0.034)], had higher incidence rates of antibiotic therapies (90.6% vs 77.2%, P=0.025), non-invasive (11.3% vs 1.7%, P<0.001) and invasive mechanical ventilation (17.0% vs 8.3%, P=0.039), ICU admission (17.0% vs 7.5%, P=0.021) and death (15.1% vs 6.1%, P=0.016). Cox proportion hazard model was carried out, and the results showed that comorbid COPD was an independent risk factor for severe COVID-19 patients progressing to critical type, after adjusting for age and gender [adjusted hazard ratio (AHR)=2.38(1.30-4.37), P=0.005] and additionally adjusting for chronic kidney diseases, hypertension, coronary heart disease [AHR=2.63(1.45-4.77), P<0.001], or additionally adjusting for some statistically significant laboratory findings [AHR=2.10(1.13-3.89), P=0.018].
    Conclusions: Severe COVID-19 patients with COPD have higher levels of disease severity, proportion of progression to critical illness and mortality rate. Individualized treatment strategies should be adopted to improve the prognosis of severe COVID-19 patients.
    MeSH term(s) Male ; Female ; Humans ; Aged ; Middle Aged ; COVID-19/complications ; SARS-CoV-2 ; Retrospective Studies ; Critical Illness ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/epidemiology
    Language Chinese
    Publishing date 2023-01-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2022.210596
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  4. Article ; Online: Clinical characteristics and outcomes of hospitalized COVID-19 patients with COPD.

    Turan, Onur / Arpınar Yigitbas, Burcu / Turan, Pakize Ayşe / Mirici, Arzu

    Expert review of respiratory medicine

    2021  Volume 15, Issue 8, Page(s) 1069–1076

    Abstract: ... of COPD patients among the population with COVID-19.: Research design and methods: Patients diagnosed ... patients was 4.96%(53/1069). There was a significant difference between COPD and non-COPD COVID-19 patients ... of pneumonia. The mortality rate was 13.2% in COPD, 7% in non-COPD patients(p = 0.092). The significant ...

    Abstract Background: Although COPD is not one of the most common comorbidities in COVID-19 patients, it can be more fatal in this group. This study aimed to investigate the characteristics and prognosis of COPD patients among the population with COVID-19.
    Research design and methods: Patients diagnosed with positive PCR test were included in our multicentered, retrospective study. Patients with airway obstruction (previous spirometry) were included in 'COPD group'.
    Results: The prevalence of COPD in COVID-19 patients was 4.96%(53/1069). There was a significant difference between COPD and non-COPD COVID-19 patients in terms of gender, mean age, presence of dyspnea, tachypnea, tachycardia, hypoxemia and presence of pneumonia. The mortality rate was 13.2% in COPD, 7% in non-COPD patients(p = 0.092). The significant predictors of mortality were higher age, lymphopenia (p < 0.001), hypoxemia (p = 0.028), high D-dimer level (p = 0.011), and presence of pneumonia (p = 0.043) in COVID-19 patients.
    Conclusions: Our research is one of the first studies investigating characteristics of COPD patients with COVID-19 in Turkey. Although COPD patients had some poor prognostic features, there was no statistical difference between overall survival rates of two groups. Age, status of oxygenization, serum D-dimer level, lymphocyte count and pneumonia were significantly associated parameters with mortality in COVID-19.
    MeSH term(s) COVID-19 ; Humans ; Pneumonia ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2479146-5
    ISSN 1747-6356 ; 1747-6348
    ISSN (online) 1747-6356
    ISSN 1747-6348
    DOI 10.1080/17476348.2021.1923484
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    Zs.A 6963: Show issues Location:
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  5. Article ; Online: Frail Older Adults with Presymptomatic SARS-CoV-2 Infection: Clinical Course and Prognosis.

    Levy, Yochai / Turjeman, Adi / Cooper, Lisa / Kagansky, Nadya / Nagulevich, Tatiana / Snir, Tamari / Hershkovitz, Avital / Weiss, Avraham / Beloosesky, Yichayaou / Leibovici Weissman, Yaara

    Gerontology

    2022  Volume 68, Issue 12, Page(s) 1393–1401

    Abstract: ... frail older adults, positive for SARS-CoV-2, and asymptomatic at the time of their admission in these units ... Background/aims: The novel coronavirus SARS-CoV-2 has caused a pandemic threatening millions ... of SARS-CoV-2-positive, asymptomatic, frail older adults.: Methods: A retrospective cohort study was ...

    Abstract Background/aims: The novel coronavirus SARS-CoV-2 has caused a pandemic threatening millions of people worldwide. This study aimed to describe clinical characteristics, outcomes, and risk factors of SARS-CoV-2-positive, asymptomatic, frail older adults.
    Methods: A retrospective cohort study was conducted in 6 designated COVID-19 units, in skilled nursing homes. Subjects were severely frail older adults, positive for SARS-CoV-2, and asymptomatic at the time of their admission in these units. Residents' characteristics and symptoms were obtained via electronic medical records. The primary outcome was a composite of death or hospitalization by day 40. We looked at time to the primary outcome and used Cox regression for a multivariate analysis.
    Results: During March-November 2020, 849 residents met inclusion criteria. Median age was 84 years. Most were completely dependent for basic activities of daily living and showed cognitive impairment. Six hundred forty-one (75.5%) residents were discharged after considered cured from COVID-19, 125 (14.7%) were hospitalized, and 82 (9.7%) died in the facilities. In survival analysis, 35% reached the primary outcome of death or hospitalization by day 40. Age (hazard ratio [HR] 1.23; 95% confidence interval [CI] 1.1-1.4), male gender (HR 1.41; 95% CI: 1.1-1.88), and COPD (HR 1.8; 95% CI: 1.23-2.67) were significant risk factors.
    Conclusions: In this large cohort, we report care and prognosis of asymptomatic older adults with major functional or cognitive impairments during the COVID-19 pandemic. Most presymptomatic patients do not develop severe infection, and age stays a predominant risk factor, even in the frailest older adults.
    MeSH term(s) Humans ; Male ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Frail Elderly ; Activities of Daily Living ; Retrospective Studies ; Prognosis
    Language English
    Publishing date 2022-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193798-4
    ISSN 1423-0003 ; 0304-324X
    ISSN (online) 1423-0003
    ISSN 0304-324X
    DOI 10.1159/000521412
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