Article: Parvovirus B19 may have a role in the pathogenesis of juvenile idiopathic arthritis.
2007 Volume 34, Issue 6, Page(s) 1336–1340
Abstract: ... with juvenile idiopathic arthritis (JIA) by detection of specific IgM, IgG, and viral DNA.: Methods: Serum samples of 50 patients ... Objective: To determine the prevalence of human parvovirus B19 infection in patients ... specific antibodies. The parvovirus B19 genome was detected by nested polymerase chain reaction (PCR). The average age ...
| Abstract | Objective: To determine the prevalence of human parvovirus B19 infection in patients with juvenile idiopathic arthritis (JIA) by detection of specific IgM, IgG, and viral DNA. Methods: Serum samples of 50 patients with diagnosis of JIA and 39 healthy controls were analyzed by ELISA to detect IgG and IgM anti-B19-specific antibodies. The parvovirus B19 genome was detected by nested polymerase chain reaction (PCR). The average age of the patients was 9.6 years (2-14 yrs); 30 were female (60%) and 20 male (40%). The definitive diagnoses of these patients corresponded to 19 systemic forms (38%), 11 to the oligoarticular variety (22%) and 20 to the polyarticular (40%). The average age of the control group was 7.8 years (2-16 yrs); the distribution by sex was 25 females (64%) and 14 males (36%). Results: IgM against parvovirus B19 was detected in 20% of the cases (10 patients) and B19 DNA genome by PCR in 48% (24 patients); in 10% of the cases (5 patients), both markers were detected. IgG was found in 32% (16 patients). In the control group neither IgM nor the viral genome was detected. However, 43.5% of the controls (17/39) had IgG against parvovirus B19, indicating past infection by the virus. Conclusion: Our study confirms recent observations regarding a high prevalence of viral DNA in JIA patients and a possible role of this viral infection in JIA pathogenesis. |
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| MeSH term(s) | Adolescent ; Antibodies, Viral/blood ; Arthritis, Juvenile/physiopathology ; Arthritis, Juvenile/virology ; Case-Control Studies ; Child ; Child, Preschool ; DNA, Viral/blood ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Male ; Parvoviridae Infections/complications ; Parvoviridae Infections/epidemiology ; Parvoviridae Infections/immunology ; Parvovirus B19, Human/genetics ; Parvovirus B19, Human/immunology ; Prevalence | ||||||||||
| Chemical Substances | Antibodies, Viral ; DNA, Viral ; Immunoglobulin G ; Immunoglobulin M | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2007-06 | ||||||||||
| Publishing country | Canada | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 194928-7 | ||||||||||
| ISSN | 1499-2752 ; 0315-162X | ||||||||||
| ISSN (online) | 1499-2752 | ||||||||||
| ISSN | 0315-162X | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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