Article ; Online: Cross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020.
2021 Volume 11, Issue 2, Page(s) e044384
Abstract: ... or admitted for COVID-19 at LNWH during March and April 2020 MAIN OUTCOME MEASURES: Descriptive and ... cohort study.: Setting: London North West Healthcare NHS Trust (LNWH).: Participants: Patients tested and ... of COVID-19 in subjects tested at or admitted to hospitals in North West London.: Design: Observational ...
| Abstract | Objective: The aim of this paper is to describe evolution, epidemiology and clinical outcomes of COVID-19 in subjects tested at or admitted to hospitals in North West London. Design: Observational cohort study. Setting: London North West Healthcare NHS Trust (LNWH). Participants: Patients tested and/or admitted for COVID-19 at LNWH during March and April 2020 MAIN OUTCOME MEASURES: Descriptive and analytical epidemiology of demographic and clinical outcomes (intensive care unit (ICU) admission, mechanical ventilation and mortality) of those who tested positive for COVID-19. Results: The outbreak began in the first week of March 2020 and reached a peak by the end of March and first week of April. In the study period, 6183 tests were performed in on 4981 people. Of the 2086 laboratory confirmed COVID-19 cases, 1901 were admitted to hospital. Older age group, men and those of black or Asian minority ethnic (BAME) group were predominantly affected (p<0.05). These groups also had more severe infection resulting in ICU admission and need for mechanical ventilation (p<0.05). However, in a multivariate analysis, only increasing age was independently associated with increased risk of death (p<0.05). Mortality rate was 26.9% in hospitalised patients. Conclusion: The findings confirm that men, BAME and older population were most commonly and severely affected groups. Only older age was independently associated with mortality. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/mortality ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units ; London/epidemiology ; Male ; Middle Aged ; Respiration, Artificial ; Risk Factors ; Young Adult |
| Language | English |
| Publishing date | 2021-02-18 |
| Publishing country | England |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2599832-8 |
| ISSN | 2044-6055 ; 2044-6055 |
| ISSN (online) | 2044-6055 |
| ISSN | 2044-6055 |
| DOI | 10.1136/bmjopen-2020-044384 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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