Article ; Online: How many times can parvovirus B19-related anemia recur in solid organ transplant recipients?
Transplant infectious disease : an official journal of the Transplantation Society
2012 Volume 14, Issue 5, Page(s) E64–70
Abstract: Parvovirus B19 (PB19) infection is known to cause acute erythroblastopenia-mediated anemia in solid ... organ transplant (SOT) recipients. Intravenous immunoglobulins (IVIg) and the decrease of immunosuppression level ... the schedule of IVIg administrations. However, a few reports have shown that PB19-related anemia can recur ...
| Abstract | Parvovirus B19 (PB19) infection is known to cause acute erythroblastopenia-mediated anemia in solid organ transplant (SOT) recipients. Intravenous immunoglobulins (IVIg) and the decrease of immunosuppression level are supposed to induce a long-term remission, although no consensus exists about the dose and the schedule of IVIg administrations. However, a few reports have shown that PB19-related anemia can recur despite this treatment, with a maximum of 3 recurrences reported. In this report, we describe in detail the cases of 2 kidney recipients with PB19 infection. They experienced, respectively, 9 and 7 PB19-related anemia recurrences. Immunosuppression level was decreased and IVIg were administered at each recurrence followed by a transitory normalization of hemoglobin level and a decrease of serum PB19 viral load. Episodes were separated by several months. These patients raise an original therapeutic management question about a frequent viral infection in SOT recipients. One patient is currently receiving IVIg every 3 months as a secondary prophylaxis without recurrence to date. These 2 case reports are followed by a review of the literature. |
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| MeSH term(s) | Adult ; Anemia/etiology ; Anemia/prevention & control ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Kidney Transplantation/adverse effects ; Male ; Parvoviridae Infections/complications ; Parvoviridae Infections/virology ; Parvovirus B19, Human/isolation & purification ; Recurrence | |||||
| Chemical Substances | Immunoglobulins, Intravenous | |||||
| Language | English | |||||
| Publishing date | 2012-10 | |||||
| Publishing country | Denmark | |||||
| Document type | Case Reports ; Journal Article ; Review | |||||
| ZDB-ID | 1476094-0 | |||||
| ISSN | 1399-3062 ; 1398-2273 | |||||
| ISSN (online) | 1399-3062 | |||||
| ISSN | 1398-2273 | |||||
| DOI | 10.1111/j.1399-3062.2012.00773.x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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