Article ; Online: Clonidine inhibits itch-related response through stimulation of α(2)-adrenoceptors in the spinal cord in mice.
European journal of pharmacology
2011 Volume 650, Issue 1, Page(s) 215–219
Abstract: ... pain - is able to suppress itch-related behavior in mice. An intraplantar injection of serotonin ... induced biting (an itch-related response), which was inhibited by intraperitoneal and intrathecal, but not ... an effective antipruritic agent and that the effect is mainly mediated by the stimulation of α(2)-adrenoceptors ...
| Abstract | The present study investigated whether clonidine - an α(2)-adrenoceptor agonist known to relieve pain - is able to suppress itch-related behavior in mice. An intraplantar injection of serotonin induced biting (an itch-related response), which was inhibited by intraperitoneal and intrathecal, but not intraplantar or intracisternal, clonidine injections. The effect of intrathecal clonidine was inhibited by intrathecal injections of phentolamine (a non-selective α-adrenoceptor antagonist) and yohimbine (a selective α(2)-adrenoceptor antagonist), but not by prazosin (a selective α(1)-adrenoceptor antagonist). The effect of intraperitoneal clonidine was also inhibited by intrathecal yohimbine. These results suggest that clonidine is an effective antipruritic agent and that the effect is mainly mediated by the stimulation of α(2)-adrenoceptors in the dorsal horn. |
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| MeSH term(s) | Adrenergic alpha-2 Receptor Antagonists/pharmacology ; Animals ; Antipruritics/administration & dosage ; Antipruritics/pharmacology ; Antipruritics/therapeutic use ; Behavior, Animal/drug effects ; Clonidine/administration & dosage ; Clonidine/pharmacology ; Clonidine/therapeutic use ; Injections ; Male ; Mice ; Pruritus/chemically induced ; Pruritus/drug therapy ; Pruritus/metabolism ; Receptors, Adrenergic, alpha-2/metabolism ; Serotonin/pharmacology ; Spinal Cord/drug effects ; Spinal Cord/metabolism | |||||
| Chemical Substances | Adrenergic alpha-2 Receptor Antagonists ; Antipruritics ; Receptors, Adrenergic, alpha-2 ; Serotonin (333DO1RDJY) ; Clonidine (MN3L5RMN02) | |||||
| Language | English | |||||
| Publishing date | 2011-01-10 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80121-5 | |||||
| ISSN | 1879-0712 ; 0014-2999 | |||||
| ISSN (online) | 1879-0712 | |||||
| ISSN | 0014-2999 | |||||
| DOI | 10.1016/j.ejphar.2010.10.011 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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