Article ; Online: Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study.
Journal of clinical immunology
2021 Volume 41, Issue 7, Page(s) 1479–1489
Abstract: Purpose: There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors ... a cross-sectional, multicenter study that included patients of any age affected by IEI and SARS-CoV-2 ... in use for IEI, clinical manifestations and severity of SARS-CoV-2 infection.: Results: 121 patients ...
| Abstract | Purpose: There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and identify factors influencing the infection. Methods: We did a cross-sectional, multicenter study that included patients of any age affected by IEI and SARS-CoV-2 infection. The variables studied were sex, age, type of IEI, comorbidities (number and type), treatment in use for IEI, clinical manifestations and severity of SARS-CoV-2 infection. Results: 121 patients were included: 55.4% female, ages from six months to 74 yo (median age = 25.1 yo). Most patients had predominantly antibody deficiency (n = 53). The infection was mostly asymptomatic (n = 21) and mild (n = 66), and one child had multisystem inflammatory syndrome (MIS-C). We could not observe sex-related susceptibility, and there was a weak correlation between age and severity of infection. The number of comorbidities was higher in severe cases, particularly bronchiectasis and cardiopathy. There were no severe cases in hereditary angioedema patients. Six patients aged 2 to 74 years died, three of them with antibody deficiency. Conclusion: The outcome was mild in most patients, but the Case Fatality Ratio was higher than in the general population. However, the type of IEI was not a determining factor for severity, except for complement deficiencies linked to milder COVID-19. The severity of SARS-CoV-2 infection seems to be more related to older age, a higher number of comorbidities and type of comorbidities (bronchiectasis and cardiopathy). |
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| MeSH term(s) | Adult ; Asymptomatic Diseases ; Brazil ; COVID-19/diagnosis ; COVID-19/mortality ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Male ; Middle Aged ; Primary Immunodeficiency Diseases/diagnosis ; Primary Immunodeficiency Diseases/mortality ; SARS-CoV-2/physiology ; Severity of Illness Index ; Survival Analysis ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/mortality ; Young Adult | |||||
| Language | English | |||||
| Publishing date | 2021-06-23 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 779361-3 | |||||
| ISSN | 1573-2592 ; 0271-9142 | |||||
| ISSN (online) | 1573-2592 | |||||
| ISSN | 0271-9142 | |||||
| DOI | 10.1007/s10875-021-01066-8 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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