Article ; Online: COVID-19-associated myoclonus in a series of five critically ill patients.
Wiener klinische Wochenschrift
2021 Volume 133, Issue 17-18, Page(s) 902–908
Abstract: ... critically ill patients with COVID-19-associated myoclonus.: Material and methods: The clinical courses and ... myoclonus in five patients suffering from the disease. The purpose of this article is to report on five ... In severe cases of COVID-19 myoclonus can manifest about 3 weeks after initial onset of symptoms. Sedation ...
| Abstract | Background: In addition to respiratory symptoms, many patients with coronavirus disease 2019 (COVID-19) present with neurological complications. Several case reports and small case series described myoclonus in five patients suffering from the disease. The purpose of this article is to report on five critically ill patients with COVID-19-associated myoclonus. Material and methods: The clinical courses and test results of patients treated in the study center ICU and those of partner hospitals are described. Imaging, laboratory tests and electrophysiological test results are reviewed and discussed. Results: In severe cases of COVID-19 myoclonus can manifest about 3 weeks after initial onset of symptoms. Sedation is sometimes effective for symptom control but impedes respiratory weaning. No viral particles or structural lesions explaining this phenomenon were found in this cohort. Conclusion: Myoclonus in patients with severe COVID-19 may be due to an inflammatory process, hypoxia or GABAergic impairment. Most patients received treatment with antiepileptic or anti-inflammatory agents and improved clinically. |
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| MeSH term(s) | COVID-19 ; Critical Illness ; Humans ; Intensive Care Units ; Myoclonus/chemically induced ; Myoclonus/diagnosis ; Myoclonus/drug therapy ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-06-15 | |||||
| Publishing country | Austria | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 200462-8 | |||||
| ISSN | 1613-7671 ; 0043-5325 ; 0300-5178 | |||||
| ISSN (online) | 1613-7671 | |||||
| ISSN | 0043-5325 ; 0300-5178 | |||||
| DOI | 10.1007/s00508-021-01890-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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