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Article: Tropical diseases of the myocardium: a review.

Groom, Zoe C / Protopapas, Aristotle D / Zochios, Vasileios

International journal of general medicine

2017 Volume 10, Page(s) 101–111

Abstract: ... In this review, we address the most frequently reported parasites that directly infect the myocardium, including ... ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases ... Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ...

Abstract	Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including
Language	English
Publishing date	2017-04-07
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S130828
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Schistosomiasis & Heart - On Behalf of the Neglected Tropical Diseases and other Infectious Diseases affecting the Heart (the NET-Heart Project).

Posada-Martínez, Edith Liliana / Gonzalez-Barrera, Luis Gerardo / Liblik, Kiera / Gomez-Mesa, Juan Esteban / Saldarriaga, Clara / Farina, Juan Maria / Parodi, Josefina / Zhou, Zier / Martinez-Selles, Manuel / Baranchuk, Adrian

Arquivos brasileiros de cardiologia

2022 Volume 118, Issue 5, Page(s) 885–893

Abstract: Background: Schistosomiasis is a Neglected Tropical Disease which may lead to cardiovascular (CV ... without adequate infrastructure for robust data collection.: Objective: This systematic review aims to assess ... an algorithm for screening of CV manifestations.: Methods: A systematic review was performed in the MEDLINE ...

Title translation	Esquistossomose e o Coração - Em Nome das Doenças Tropicais Negligenciadas e Outras Doenças Infecciosas que Afetam o Coração (Projeto NET-Heart).
Abstract	Background: Schistosomiasis is a Neglected Tropical Disease which may lead to cardiovascular (CV) complications. However, the CV involvement in schistosomiasis has yet to be fully elucidated due to the limited number of cases and lack of reliable evidence, as schistosomiasis typically occurs in locations without adequate infrastructure for robust data collection. Objective: This systematic review aims to assess cardiovascular implications of schistosomiasis, including in the diagnosis and treatment, and propose an algorithm for screening of CV manifestations. Methods: A systematic review was performed in the MEDLINE/PubMed and LILACS databases of articles on the CV involvement in schistosomiasis. Results: Thirty-three records were considered for this review: six review articles, one systematic review, one clinical trial, 14 observational studies, seven case reports, and four cases series. CV involvement includes a wide spectrum of clinical conditions, such as myocardial ischemia, ventricular dysfunction, myocarditis, pulmonary arterial hypertension, and pericarditis. Conclusions: Cardiac complications of schistosomiasis may cause long-term disability and death. Clinical monitoring, physical examination, early electrocardiogram, and echocardiogram should be considered as key measures to detect CV involvement. Due to the lack of effective treatment of complications, sanitation and education in endemic areas are necessary for the elimination of this global health problem.
MeSH term(s)	Communicable Diseases ; Heart ; Heart Diseases/diagnosis ; Heart Diseases/therapy ; Humans ; Myocarditis/diagnosis ; Neglected Diseases/diagnosis ; Observational Studies as Topic ; Schistosomiasis/diagnosis
Language	Portuguese
Publishing date	2022-02-04
Publishing country	Brazil
Document type	Journal Article ; Systematic Review
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20201384
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

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Article ; Online: Tropical diseases of the myocardium

Groom ZC / Protopapas AD / Zochios V

International Journal of General Medicine, Vol Volume 10, Pp 101-

a review

2017 Volume 111

Abstract: ... cardiomyopathy, Chagas disease, myocardium, parasitic infection, tropical infections ... of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect ... recognized as crucial factors for improving the control of cardiovascular diseases in the tropics. Clinicians ...

Abstract	Zoe C Groom,1 Aristotle D Protopapas,2 Vasileios Zochios3,4 1Costello Medical Consulting Limited, Cambridge, 2Department of Surgery, Division of Surgery and Cancer, Imperial College London, London, 3Department of Intensive Care Medicine, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, 4College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK Abstract: Cardiovascular diseases are widely distributed throughout the world. Human parasitic infections are ubiquitous. Tropical parasites are increasingly recognized as causes of cardiovascular diseases. In this review, we address the most frequently reported parasites that directly infect the myocardium, including Trypanosoma cruzi, the protozoal causative agent of American trypanosomiasis (Chagas disease), and Taenia solium, the cestode causative agent of taeniasis and cysticercosis. We also discuss tropical endomyocardial fibrosis, trichinellosis and schistosomiasis. Health systems, attitudes, the perceptions of both patients and physicians as well as socioeconomic factors should all be explored and recognized as crucial factors for improving the control of cardiovascular diseases in the tropics. Clinicians throughout the world must remain aware of imported parasites as potential causes of cardiac diseases. Keywords: cardiomyopathy, Chagas disease, myocardium, parasitic infection, tropical infections
Keywords	Cardiomyopathy ; Chagas disease ; myocardium ; parasitic infection ; tropical infections ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-04-01T00:00:00Z
Publisher	Dove Medical Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cardiomyopathies in Tropical Countries

Jean-Etienne Touze / Laurent Fourcade

World Journal of Cardiovascular Surgery , Vol 03, Iss 07, Pp 201-

Causes and Nosological Perspective

2013 Volume 208

Abstract: ... in Africa. In those areas the concept of “tropical cardiomyopathy” is still used to design all unexplained ... observed in tropical countries and second to gain a better understanding of the nosological place ... of the so-called “tropical cardiomyopathies” in the current framework of cardiomyopathies. Methods and Results ...

Abstract	Background: Cardiomyopathy is the main cause of heart failure in developing countries, mainly in Africa. In those areas the concept of “tropical cardiomyopathy” is still used to design all unexplained cardiomyopathy. The primary aim of this review is first to review t he main etiologies of cardiomyopathies observed in tropical countries and second to gain a better understanding of the nosological place of the so-called “tropical cardiomyopathies” in the current framework of cardiomyopathies. Methods and Results: We reviewed relevant references over the last forty years (June, 1976 to May 2012). Given literature data, endomyocardial fibrosis (EMF) is mainly diagnosed in sub-Saharan countries, as well as Brazil and India. Peripartum cardiomyopathy (PPCM) is observed with a higher prevalence than in temperate countries. Sickle cell anemia does not induce specific cardiomyopathy in all echocardiographic studies. Malnutrition and chronic anemia can induce reversible cardiac dysfunction. Myocardial involvement in parasitic infections is restricted to Chagas disease and probably to human African trypanosomiasis. Helminthiasis is not involved in the pathogenesis of cardiomyopathy except for the deleterious effect of high eosinophilia induced by some endemic diseases (filariasis, schistosomiasis). Primary cardiomyopathies (dilated, hypertrophic, and restrictive cardiomyopathy) have no specificity. Arrhythmogenic right ventricular dysplasia and left ventricular noncompaction are also reported and do not differ from elsewhere. Conclusions: The concept of tropical cardiomyopathy is no longer relevant as most of the cardiomyopathies observed in tropical countries have no specificity, with few exceptions (PPCM, EMF, Chagas disease). In this context, the European Society of Cardiology classification offers a simpler clinical approach and allows the inclusion of the rare tropical specificities.
Keywords	Tropical Countries ; Cardiomyopathy ; Endomyocardial Fibrosis ; Peripartum Cardiomyopathy ; Chagas Disease ; Surgery ; RD1-811 ; Medicine ; R ; DOAJ:Surgery ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	610
Language	English
Publishing date	2013-11-01T00:00:00Z
Publisher	Scientific Research Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tropical endomyocardial fibrosis

Vijay Kumar Verma / Khwaja Saifullah Zafar

International Journal of Research in Medical Sciences, Vol 2, Iss 4, Pp 1267-

an overview

2014 Volume 1277

Abstract: Tropical endomyocardial fibrosis is the commonest form of endemic restrictive cardiomyopathy ... in the tropical and subtropical regions of the world such as Africa, Latin America and Asia including southern ... to some extent. We have conducted a systematic review of the most intriguing aspects of epidemiology ...

Abstract	Tropical endomyocardial fibrosis is the commonest form of endemic restrictive cardiomyopathy that affects mainly children and adolescents, and is geographically restricted to some poor areas in the tropical and subtropical regions of the world such as Africa, Latin America and Asia including southern districts of India especially in the coastal belt of Kerala state. Sub-endocardial fibrosis affecting the apices and the inflow tracts of the right or left ventricle, or both; and varying degree of atrioventricular valve regurgitation defines the disease. Chronic systemic venous hypertension and severe pulmonary hypertension are characteristic features of right ventricular and Left ventricular endomyocardial fibrosis respectively. Due to lack of resources for research in the disease endemic areas, the exact epidemiology, etiology and pathogenesis remain unknown, and the natural history is incompletely understood. Various infections and toxic factors were postulated regarding its etiology. During the last few years, incidence of the disease has decreased considerably because of the significant improvement in the living standards of the people with the corresponding decline in the childhood malnutrition, infections, worm infestations and associated eosinophilia. It is a condition with high morbidity and mortality, for which no effective therapy is available. However, surgical management improves the natural history of this disease to some extent. We have conducted a systematic review of the most intriguing aspects of epidemiology, natural history, clinical picture and management of endomyocardial fibrosis, proposing new ways to increase research into this challenging and neglected cardiovascular disease. We relied primarily on articles in the MEDLINE database with either and lsquo; and lsquo;endomyocardial fibrosis'' or and lsquo; and lsquo;endomyocardial sclerosis'' in the title. [Int J Res Med Sci 2014; 2(4.000): 1267-1277]
Keywords	Endomyocardial fibrosis ; Restrictive cardiomyopathy ; Eosinophilia ; Malnutrition ; Endemic disease ; Diastolic dysfunction ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	Medip Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tropical endomyocardial fibrosis

Vijay Kumar Verma / Khwaja Saifullah Zafar

International Journal of Research in Medical Sciences, Vol 2, Iss 4, Pp 1267-

an overview

2014 Volume 1277

Abstract	Tropical endomyocardial fibrosis is the commonest form of endemic restrictive cardiomyopathy that affects mainly children and adolescents, and is geographically restricted to some poor areas in the tropical and subtropical regions of the world such as Africa, Latin America and Asia including southern districts of India especially in the coastal belt of Kerala state. Sub-endocardial fibrosis affecting the apices and the inflow tracts of the right or left ventricle, or both; and varying degree of atrioventricular valve regurgitation defines the disease. Chronic systemic venous hypertension and severe pulmonary hypertension are characteristic features of right ventricular and Left ventricular endomyocardial fibrosis respectively. Due to lack of resources for research in the disease endemic areas, the exact epidemiology, etiology and pathogenesis remain unknown, and the natural history is incompletely understood. Various infections and toxic factors were postulated regarding its etiology. During the last few years, incidence of the disease has decreased considerably because of the significant improvement in the living standards of the people with the corresponding decline in the childhood malnutrition, infections, worm infestations and associated eosinophilia. It is a condition with high morbidity and mortality, for which no effective therapy is available. However, surgical management improves the natural history of this disease to some extent. We have conducted a systematic review of the most intriguing aspects of epidemiology, natural history, clinical picture and management of endomyocardial fibrosis, proposing new ways to increase research into this challenging and neglected cardiovascular disease. We relied primarily on articles in the MEDLINE database with either and lsquo; and lsquo;endomyocardial fibrosis'' or and lsquo; and lsquo;endomyocardial sclerosis'' in the title. [Int J Res Med Sci 2014; 2(4.000): 1267-1277]
Keywords	Endomyocardial fibrosis ; Restrictive cardiomyopathy ; Eosinophilia ; Malnutrition ; Endemic disease ; Diastolic dysfunction ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	Medip Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CTA publishes a manual on tropical veterinary parasitology

Technical Centre for Agricultural and Rural Cooperation

Spore

2014

Abstract: ... of domestic herbivores in tropical Africa. Since most of the diseases also occur in Mediterranean Africa ... discussed. 'A Manual of Tropical Veterinary Parasitology' is a comprehensive study and includes detailed ... An English-language version of a three-volume book on tropical veterinary parasitology, has just ...

Abstract	An English-language version of a three-volume book on tropical veterinary parasitology, has just been jointly published by CTA and CAB International. The French original was first published by the Institut d'Elevage et de Medecine Veterinaire des Pays Tropicaux (IEMVT). The 'Manual of Tropical Veterinary Parasitology' has been translated from the French by Mira Shah-Fisher and Dr R. Ralph Say. The first of the three volumes is entitled 'Helminths of Livestock and Poultry in Tropical Africa'. It is written by P.M. Troncy and deals with all the parasitic infections of importance in Africa. It also covers coccidiosis, as well as all the diseases transmitted by ticks (including babesiosis and theileriosis). There is a full account of the morphology, identification and biology of ticks found in western and central Africa Volume II, 'African Animal Trypanosomes' by J. Itard, deals with trypanosomes as well as the parasitic disorders in mammals caused by protozoa belonging to the genus Trypanosoma. These parasites multiply in the bloodstream, lymphatic vessels and tissues including the cardiac muscle and central nervous systems. In Africa they are transmitted by various haematophagous insects, mainly Glossina spp., commonly known as tsetse flies, which occur exclusively in Africa over an area of approximately 10 million sq km, extending from 15 north to 20 south of the Equator. The tsetse flies play a primary role in the epidemiology of these economically and socially important diseases. Part lIl, written by P.C. Morel, covers tick-borne diseases of domestic herbivores in tropical Africa. Since most of the diseases also occur in Mediterranean Africa, the study was extended to cover this region - for a continent-wide review. However, as regards tick identification, only those species that currently infest livestock in west, central and north-west Africa are discussed. 'A Manual of Tropical Veterinary Parasitology' is a comprehensive study and includes detailed indexes and bibliographic references for each section. It is ...
Language	English
Publishing date	2014-10-08T13:16:06Z
Publisher	Technical Centre for Agricultural and Rural Cooperation
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anisotropic Cardiac Conduction.

Kotadia, Irum / Whitaker, John / Roney, Caroline / Niederer, Steven / O'Neill, Mark / Bishop, Martin / Wright, Matthew

Arrhythmia & electrophysiology review

2021 Volume 9, Issue 4, Page(s) 202–210

Abstract: ... myocardial fibrosis, gap junction distribution and function are all considered to contribute to anisotropic ... conduction. In disease states, anisotropic conduction may be enhanced, and is implicated, in the genesis ... anisotropic and its orientation is determined by myocyte direction. Cell shape and size, excitability ...

Abstract	Anisotropy is the property of directional dependence. In cardiac tissue, conduction velocity is anisotropic and its orientation is determined by myocyte direction. Cell shape and size, excitability, myocardial fibrosis, gap junction distribution and function are all considered to contribute to anisotropic conduction. In disease states, anisotropic conduction may be enhanced, and is implicated, in the genesis of pathological arrhythmias. The principal mechanism responsible for enhanced anisotropy in disease remains uncertain. Possible contributors include changes in cellular excitability, changes in gap junction distribution or function and cellular uncoupling through interstitial fibrosis. It has recently been demonstrated that myocyte orientation may be identified using diffusion tensor magnetic resonance imaging in explanted hearts, and multisite pacing protocols have been proposed to estimate myocyte orientation and anisotropic conduction in vivo. These tools have the potential to contribute to the understanding of the role of myocyte disarray and anisotropic conduction in arrhythmic states.
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2813970-7
ISSN	2050-3377 ; 2050-3369
ISSN (online)	2050-3377
ISSN	2050-3369
DOI	10.15420/aer.2020.04
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulatory effect of anisotropic structure on cardiomyocyte maturation

Yue Xu / Miao Xiao / Xiaoyun Li / Ziyun Jiang

STEMedicine, Vol 4, Iss

2023 Volume 3

Abstract: ... myocardial tissue. This review focuses on the key indicators of anisotropic structures provided ... Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited ...

Abstract	Cardiovascular disease (CVD) is the leading cause of death worldwide. Due to the limited regenerative capacity of the adult heart, treatments based on human pluripotent stem cells (hPSCs) have become the focus of a great deal of research. Human pluripotent stem cell–derived cardiomyocytes (hPSC-CMs) can provide an ideal cell source for CVD model construction, cardiac tissue repair, and drug cardiotoxicology research. However, the immaturity of hPSC-CMs seriously restricts its clinical application. The maturation of cardiomyocytes depends on the orderly arrangement of myofilaments and the increase of the expression of connexin, so the geometric regulation of bioengineering substrate is one of the keys to the maturation of engineered myocardial tissue. This review focuses on the key indicators of anisotropic structures provided by biomaterials to improve the maturation characteristics of cardiomyocytes, so as to promote the maturation of cardiomyocytes, and looks forward to the development direction in this field.
Keywords	Cardiovascular disease ; human pluripotent stem cells ; cardiomyocytes ; bioengineering ; anisotropic structure ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Innovation Publishing House Pte. Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retrospective review of 27 European cases of fatal elephant endotheliotropic herpesvirus-haemorrhagic disease reveals evidence of disseminated intravascular coagulation.

Perrin, K L / Kristensen, A T / Bertelsen, M F / Denk, D

Scientific reports

2021 Volume 11, Issue 1, Page(s) 14173

Abstract: ... of the current study was to perform a blinded, retrospective pathology review of European EEHV-HD fatalities ... Elephant endotheliotropic herpesvirus haemorrhagic disease (EEHV-HD) is widely acknowledged ... including severe acute myocardial haemorrhage and subsequent cardiac failure. Systemic inflammation observed ...

Abstract	Elephant endotheliotropic herpesvirus haemorrhagic disease (EEHV-HD) is widely acknowledged as the most common cause of mortality in young Asian elephants (Elephas maximus) in captivity. The objective of the current study was to perform a blinded, retrospective pathology review of European EEHV-HD fatalities, constituting the largest systematic assessment of EEHV-HD pathology to date. Findings between viral genotypes were compared with the aim to investigate if disseminated intravascular coagulation (DIC) could be substantiated as a significant complicating factor, thereby increasing the understanding of disease pathophysiology. Immunohistochemical staining confirmed endothelial cell (EC) damage and the presence of EC intranuclear inclusion bodies, demonstrating a direct viral cytopathic effect. Microthrombi were observed in 63% of cases in several organs, including lungs, which, together with widespread haemorrhage and thrombocytopenia reported in EEHV-HD case reports, supports the presence of overt DIC as a serious haemostatic complication of active EEHV infection. Death was attributed to widespread vascular damage with multi-organ dysfunction, including severe acute myocardial haemorrhage and subsequent cardiac failure. Systemic inflammation observed in the absence of bacterial infection may be caused by cytokine release syndrome. Findings reinforce the necessity to investigate cytokine responses and haemostatic status during symptomatic and asymptomatic EEHV viraemia, to potentially support the use of anti-inflammatory treatment in conjunction with anti-viral therapy and cardiovascular support.
MeSH term(s)	Animals ; Disseminated Intravascular Coagulation/pathology ; Disseminated Intravascular Coagulation/veterinary ; Disseminated Intravascular Coagulation/virology ; Edema/pathology ; Elephants/virology ; Hemorrhage/pathology ; Hemorrhage/veterinary ; Hemorrhage/virology ; Herpesviridae/physiology ; Herpesviridae Infections/pathology ; Herpesviridae Infections/veterinary ; Herpesviridae Infections/virology ; Inclusion Bodies, Viral/metabolism ; Inflammation/pathology ; Lymph Nodes/pathology ; Organ Specificity ; Retrospective Studies ; Severity of Illness Index
Language	English
Publishing date	2021-07-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-93478-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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