Article: High Levels of IL-8 and MCP-1 in Cerebrospinal Fluid of COVID-19 Patients with Cerebrovascular Disease.
2021 Volume 30, Issue 3, Page(s) 256–261
Abstract: ... with cerebrovascular disease and COVID-19. Although the SARS-CoV-2 mRNA was not detected in CSF of both patients ... These results suggest that neuroinflammation plays a key role in cerebrovascular disease and COVID-19. ... macrophages, it is feasible that cerebrovascular disease related-neuroinflammation found in both patients ...
| Abstract | The coronavirus family has tropism for the Central Nervous System (CNS), however, there is no solid evidence demonstrating that the neurological effects of COVID-19 result from direct viral infection or systemic inflammation. The goals of this study were to examine the cytokine profile and the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) in cerebrospinal fluids (CSF) from two patients with cerebrovascular disease and COVID-19. Although the SARS-CoV-2 mRNA was not detected in CSF of both patients, we found abnormally high levels of numerous proinflammatory cytokines and chemokines, especially IL-8 and MCP-1. Since these chemokines mediate activation and recruitment of neutrophils, monocytes, and macrophages, it is feasible that cerebrovascular disease related-neuroinflammation found in both patients results from an exacerbated inflammatory response instead of SARS-CoV-2 direct invasion to CNS. These results suggest that neuroinflammation plays a key role in cerebrovascular disease and COVID-19. |
|---|---|
| Language | English |
| Publishing date | 2021-07-06 |
| Publishing country | Korea (South) |
| Document type | Case Reports |
| ZDB-ID | 2639017-6 |
| ISSN | 2093-8144 ; 1226-2560 |
| ISSN (online) | 2093-8144 |
| ISSN | 1226-2560 |
| DOI | 10.5607/en21009 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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