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  1. Article: Long-Term X-ray Findings in Patients With Coronavirus Disease-2019.

    Gupta, Aarzoo / Garg, Ishan / Iqbal, Abbas / Talpur, Abdul Subhan / Mañego, Alyanna Marie B / Kavuri, Rama Kalyani / Bachani, Parkash / Naz, Sidra / Iqbal, Zoya Qamar

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15304

    Abstract: ... commonly used techniques for diagnosing and assessing prognosis in patients with coronavirus disease-2019 ... recovery, in patients with COVID-19. This will help identify patients suffering from long-term consequences ... discharged after negative PCR was done. Participants with positive X-ray findings, which included ...

    Abstract Introduction: Reverse transcription-polymerase chain reaction (RT-PCR) and chest X-ray (CXR) are commonly used techniques for diagnosing and assessing prognosis in patients with coronavirus disease-2019 (COVID-19). This study aims to highlight the long-term radiological findings observed on CXR after recovery, in patients with COVID-19. This will help identify patients suffering from long-term consequences of COVID-19 and help them provide adequate care.
    Methods: This study was conducted in the COVID-19 unit of a tertiary care hospital, Pakistan from August 2020 to February 2021. CXR of patients who were being discharged after negative PCR was done. Participants with positive X-ray findings, which included consolidation, reticular thickening, ground-glass opacities (GGO), pulmonary nodules, and pleural effusions, were enrolled in the study after getting informed consent. All findings were recorded in a self-structured questionnaire. Participants were scheduled to come for follow-up on day 30 after their initial CXR, where their CXR was repeated.
    Result: Our results showed that n=429 (60.2%) participants had positive CXR at the time of discharge. After 30 days, n=371 participants returned for a follow-up X-ray. Out of the 371 participants, after 30 days, 123 participants still had positive CXR. Fatigue (41.4%) was the common symptom after 30 days. The most common finding was consolidation (82.1%), followed by reticular thickening (23.5%) on day 30.
    Conclusion: In this study, although most of the patients completely recovered serologically from COVID-19, they still had radiological findings in their chest X-rays. Radiological findings are especially important in predicting the clinical course of the disease and may be used to monitor long-term complications.
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Investigating the potential added value of [ 18 F]FDG-PET/CT in long COVID patients with persistent symptoms: a proof of concept study.

    Chen, Linda L / van de Burgt, Alina / Smit, Frits / Audhoe, Rowena S / de Boer, Sandra M / van Velden, Floris H P / de Geus-Oei, Lioe-Fee

    Nuclear medicine communications

    2023  Volume 44, Issue 6, Page(s) 495–501

    Abstract: Objective: Since the end of 2019, the coronavirus disease 2019 (COVID-19) virus has infected ... As more and more patients emerge with long COVID who have symptoms of fatigue, myalgia and joint pain ... FDG-PET/computed tomography (CT) for this group of long COVID patients.: Methods: For this proof ...

    Abstract Objective: Since the end of 2019, the coronavirus disease 2019 (COVID-19) virus has infected millions of people, of whom a significant group suffers from sequelae from COVID-19, termed long COVID. As more and more patients emerge with long COVID who have symptoms of fatigue, myalgia and joint pain, we must examine potential biomarkers to find quantifiable parameters to define the underlying mechanisms and enable response monitoring. The aim of this study is to investigate the potential added value of [ 18 F]FDG-PET/computed tomography (CT) for this group of long COVID patients.
    Methods: For this proof of concept study, we evaluated [ 18 F]FDG-PET/CT scans of long COVID patients and controls. Two analyses were performed: semi-quantitative analysis using target-to-background ratios (TBRs) in 24 targets and total vascular score (TVS) assessed by two independent nuclear medicine physicians. Mann-Whitney U -test was performed to find significant differences between the two groups.
    Results: Thirteen patients were included in the long COVID group and 25 patients were included in the control group. No significant differences ( P  < 0.05) were found between the long COVID group and the control group in the TBR or TVS assessment.
    Conclusion: As we found no quantitative difference in the TBR or TVS between long COVID patients and controls, we are unable to prove that [ 18 F]FDG is of added value for long COVID patients with symptoms of myalgia or joint pain. Prospective cohort studies are necessary to understand the underlying mechanisms of long COVID.
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography ; Post-Acute COVID-19 Syndrome ; Proof of Concept Study ; Prospective Studies ; Myalgia ; COVID-19/diagnostic imaging ; Tomography, X-Ray Computed ; Radiopharmaceuticals
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 758141-5
    ISSN 1473-5628 ; 0143-3636
    ISSN (online) 1473-5628
    ISSN 0143-3636
    DOI 10.1097/MNM.0000000000001689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of long-term radiological findings, pulmonary functions, and health-related quality of life in survivors of severe COVID-19.

    Bardakci, Mustafa Ilteris / Ozturk, Esin Nagihan / Ozkarafakili, Mufide Arzu / Ozkurt, Huseyin / Yanc, Ugur / Yildiz Sevgi, Dilek

    Journal of medical virology

    2021  Volume 93, Issue 9, Page(s) 5574–5581

    Abstract: Objective: It was aimed to evaluate long-term radiological changes in severe coronavirus disease ... 2019 (COVID-19) patients, to investigate pulmonary function, exercise capacities, and health-related ... properly manage the long-term problems that may arise. ...

    Abstract Objective: It was aimed to evaluate long-term radiological changes in severe coronavirus disease 2019 (COVID-19) patients, to investigate pulmonary function, exercise capacities, and health-related quality of life results.
    Methods: Sixty-five patients with severe COVID-19 pneumonia were evaluated in the sixth month after discharge from the hospital. Spirometry, 6 min walking test (6MWT), and short form of health-related quality of life scale (SF-36) were applied in the sixth month. Chest computed tomography (CT) was performed and the findings were grouped according to lung involvement.
    Results: Forty-nine male and 16 female patients were included in the study. Forced expiratory volume in 1 s (FEV1)% values of 18 patients (30.5%), forced vital capacity (FVC)% values of 27 patients (45.8%), and 6MWT of 13 patients (23.2%) were found lower than expected in the sixth month. On the SF-36 scale, physical function, energy-vitality, social functionality, pain, and general health parameters were found lower than normal. Minimal interstitial changes in chest CT were seen in 26 patients. Nine patients had lung area involvement between 10% and 50% of the surface, there was a correlation between FEV1% and FVC% values in this group. There was severe pulmonary fibrosis in four patients. There was a correlation between pulmonary function and physical function and general perception of health from SF-36 scale subparameters.
    Conclusion: Functional and radiological abnormalities were detected in a significant number of patients in the sixth month after severe COVID-19 pneumonia. A systematic monitoring plan must be established to assess and properly manage the long-term problems that may arise.
    MeSH term(s) Adult ; Aged ; COVID-19/diagnosis ; COVID-19/physiopathology ; Female ; Follow-Up Studies ; Humans ; Lung/physiopathology ; Male ; Middle Aged ; Patient Discharge ; Quality of Life ; Respiratory Function Tests ; SARS-CoV-2/isolation & purification ; Spirometry ; Survivors ; Time Factors ; Tomography, X-Ray Computed ; Turkey ; Walk Test
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical Characteristics and the Long-Term Post-recovery Manifestations of the COVID-19 Patients—A Prospective Multicenter Cross-Sectional Study

    Abu Taiub Mohammed Mohiuddin Chowdhury / Md Rezaul Karim / Md. Ahasan Ali / Jahirul Islam / Yarui Li / Shuixiang He

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: Objective: Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 ... present to an extent. Laboratory findings like chest X-ray, ESR, white blood cell (WBC) count ... Initial hematological and radiology findings of the hospitalized patients except for intensive care unit ...

    Abstract Objective: Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global issue. In addition to managing acute cases, post-COVID-19 persisting symptoms/complaints and different hematological values are of great concern. These have an impact on the patient's well-being and are yet to be evaluated. Therefore, clinical and primary diagnosis based on routine laboratory findings bears high importance during the initial period of COVID-19, especially in regions with fewer diagnostic facilities.Methods: Clinical information and associated complaints of the COVID-19 illness confirmed by reverse transcription-polymerase chain reaction (RT-PCR) were collected directly from the patients. Regular follow-ups were obtained on the phone every 2 weeks following recovery for 20 weeks. Initial hematological and radiology findings of the hospitalized patients except for intensive care unit (ICU) and high dependency units (HDUs) and a follow-up evaluation after 4 weeks following recovery were analyzed.Results: The post-COVID-19 persisting symptoms/complaints were found among 21.4% of symptomatic patients, which persisted for ≥20 weeks and had a significant relationship with the duration of COVID-19 illness and the existing comorbidity (p < 0.05). Post-COVID-19 primary type 2 diabetes mellitus (DM, 0.64%) and hypertension (HTN, 1.28%) and unstable DM (54.55%) and HTN (34.78%) to the pre-existing diabetic and hypertensive patients were observed. Post-recovery remarkable changes in the laboratory values included leukocytosis (16.1%), lymphocytosis (14.5%), and an increased prothrombin time (PT, 25.8%). Abnormalities in the D-dimer, serum ferritin, hemoglobin, and erythrocyte sedimentation rate (ESR) levels were present to an extent. Laboratory findings like chest X-ray, ESR, white blood cell (WBC) count, lymphocyte count, C-reactive protein (CRP), serum glutamic pyruvic transaminase (SGPT), serum ferritin, PT, D-dimer, and serum creatinine are important markers for the ...
    Keywords COVID-19 ; SARS-CoV-2 ; clinical characteristics ; post-recovery manifestations ; Bangladesh ; post-COVID-19 syndrome ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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