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Article: Acute basophilic leukemia: case report.

Gupta, Ritu / Jain, Paresh / Anand, Mona

2004 Volume 76, Issue 2, Page(s) 134–138

Abstract: ... of acute basophilic leukemia in a child who was referred to our Center, arriving with partially treated ... acute lymphoblastic leukemia. Basophilic differentiation on light microscopy was evident from the coarse basophilic granules ... revealed translocation t(8;21)(q22;q22). A diagnosis of acute basophilic leukemia with t(8;21) was made ...

Abstract	The term "basophilic leukemia" has been in use for 75 years. However, consistent diagnostic criteria are lacking. This is due to the rarity of the disease and to the routine unavailability of special tests that are often required to confirm a diagnosis. We report an unusual case of acute basophilic leukemia in a child who was referred to our Center, arriving with partially treated acute lymphoblastic leukemia. Basophilic differentiation on light microscopy was evident from the coarse basophilic granules in blasts, a progressive maturation of blasts toward basophils, and toluidine positivity on cytochemistry. Blasts showed a myeloid immunophenotype (CD13+, CD33+, CD117+) with a characteristic dual positivity for CD34 and CD25, highly suggestive of basophilic nature of the blasts. Conventional cytogenetic studies revealed translocation t(8;21)(q22;q22). A diagnosis of acute basophilic leukemia with t(8;21) was made. Review of pre-therapy slides showed features consistent with AML-M2 with basophilia. There were no basophilic blasts. With these features, a diagnosis of acute basophilic leukemia secondary to AML-M2 was made. In our patient, basophilic leukemia appears to have evolved from selective clonal proliferation of "basophil-committed blasts" during the course of the disease in a case of AML-M2 with basophilia.
MeSH term(s)	Antigens, CD/blood ; Basophils/pathology ; Blast Crisis ; Child ; Humans ; Leukemia, Basophilic, Acute/blood ; Leukemia, Basophilic, Acute/diagnosis ; Male
Chemical Substances	Antigens, CD
Language	English
Publishing date	2004-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.10446
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Article ; Online: Acute basophilic leukemia in a patient with down syndrome: A case report and review of literature.

Singh, Anu / Shetty, Dhanlaxmi / Patil, Jagruti / More, Manisha / Chatterjee, Gaurav / Rajpal, Sweta / Patkar, Nikhil V / Subramanian, Papagudi G / Gujral, Sumeet / Tembhare, Prashant R

International journal of laboratory hematology

2023 Volume 45, Issue 6, Page(s) 972–978

MeSH term(s)	Humans ; Leukemia, Basophilic, Acute ; Down Syndrome/complications ; Karyotyping ; Basophils
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Review ; Case Reports ; Letter
ZDB-ID	2268590-X
ISSN	1751-553X ; 1751-5521 ; 0141-9854
ISSN (online)	1751-553X
ISSN	1751-5521 ; 0141-9854
DOI	10.1111/ijlh.14117
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Zs.A 1499: Show issues

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Article ; Online: Decitabine as a treatment choice for de novo acute basophilic leukemia: transient response-a case report.

Cao, Lei / Wang, Rong / Wang, Yan / Zhao, Si-Shu / Yang, Hui / Xu, Ji / Long, Qi-Qiang / He, Guang-Sheng / Li, Jian-Yong

Translational cancer research

2022 Volume 9, Issue 2, Page(s) 1288–1293

Abstract: Acute basophilic leukemia (ABL), as a rare form of acute myeloid leukaemia (AML) accounts for <1 ... of cases of AML. ABL has not been detected for encouragingly specific targets. Here we report a de novo ... fragile ABL case treated with decitabine based regimen with transient response even if overall survival ...

Abstract	Acute basophilic leukemia (ABL), as a rare form of acute myeloid leukaemia (AML) accounts for <1% of cases of AML. ABL has not been detected for encouragingly specific targets. Here we report a de novo fragile ABL case treated with decitabine based regimen with transient response even if overall survival was a 3-month. The case of a 79-year-old male who was complained of fever, rashes and cytopenia is reported in the current study. The diagnosis of ABL was identified due to characteristic cytomorphological features and immunophenotype of myeloid blast cells without the Philadelphia chromosome. The patient initially presented with short-term improvement with decitabine. Combination of decitabine and arsenic trioxide in second chemotherapy regimen didn't reverse the end of death with a 3 months overall survival. In conclusion, our study revealed that decitabine may be an efficient therapeutic option in ABL patients and warranted much more exploration in use.
Language	English
Publishing date	2022-01-15
Publishing country	China
Document type	Case Reports
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr.2019.12.14
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Article: Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report.

Luo, Xiao-Hua / Zhu, Yan / Tang, Xiao-Qiong

Oncology letters

2014 Volume 8, Issue 6, Page(s) 2513–2516

Abstract: Acute basophilic leukemia (ABL) is a rare and poorly characterized form of leukemia. The case ... in the current report. A gastroscopy was conducted and indicated a gastric antral ulcer. The diagnosis of ABL was ... with excessive histamine release from basophilic cells. Thus, the administration of H1- and H2-receptor ...

Abstract	Acute basophilic leukemia (ABL) is a rare and poorly characterized form of leukemia. The case of a 65-year-old male who complained of dizziness, maculopapular skin lesions and melena is described in the current report. A gastroscopy was conducted and indicated a gastric antral ulcer. The diagnosis of ABL was determined due to characteristic cytomorphological features, the myeloid immunophenotype of the blast cells (identified to be positive for cluster of differentiation [CD]25 and CD123) in addition to the absence of the Philadelphia chromosome and a c-kit D816V mutation. The patient initially demonstrated clinical improvement as a result of chemotherapy, however, subsequently deteriorated. The gastric and skin manifestations of ABL may be associated with excessive histamine release from basophilic cells. Thus, the administration of H1- and H2-receptor antagonists, proton pump inhibitors and steroids is proposed in order to minimize these associated complications.
Language	English
Publishing date	2014-09-17
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2014.2544
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Article: Acute basophilic leukaemia: a case report.

Kokandakar, H R / Tembhare, P R / Mamoon, Alfatmi / Mulay, V M / Bhople, K S

Indian journal of pathology & microbiology

2007 Volume 50, Issue 2, Page(s) 443–446

Abstract: ... of this rare condition. We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement ... Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo ...

Abstract	Acute basophilic leukaemia is an uncommon form of acute leukaemia, rarely occurring as de novo disease. Due to rarity of the disease, consistent diagnostic criteria for the identification of this entity still remain the topic of discussion. Immunophenotypic profile, electron microscopy and cytogenetic analysis in addition to morphological features, are said to be highly desirable for correct identification of this entity. In set-up like ours, where such facilities are either not available or not in reach of the patients due to financial constraints, morphological features and simple technique like demonstration of metachromasia in blasts with toluidine blue stain remain the most useful diagnostic tool for identification of this rare condition. We present a case of acute basophilic leukaemia with (11q23)-MLL gene rearrangement, in an 18-year-old male with review of literature and discussion of diagnostic criteria.
MeSH term(s)	Adolescent ; Coloring Agents ; Gene Rearrangement ; Histone-Lysine N-Methyltransferase ; Humans ; Leukemia, Basophilic, Acute/diagnosis ; Leukemia, Basophilic, Acute/genetics ; Leukemia, Basophilic, Acute/pathology ; Male ; Myeloid-Lymphoid Leukemia Protein/genetics ; Staining and Labeling ; Tolonium Chloride
Chemical Substances	Coloring Agents ; KMT2A protein, human ; Myeloid-Lymphoid Leukemia Protein (149025-06-9) ; Tolonium Chloride (15XUH0X66N) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
Language	English
Publishing date	2007-09-18
Publishing country	India
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	197621-7
ISSN	0974-5130 ; 0377-4929
ISSN (online)	0974-5130
ISSN	0377-4929
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Article: Klinefelter syndrome and acute basophilic leukaemia--case report.

Ljubić, Nives / Lang, Nada / Skelin, Ika Kardum / Lasan, Ruzica / Dominis, Mara / Perković, Leila / Zupanić-Krmek, Dubraka / Grgurević-Batinica, Anita

Collegium antropologicum

2010 Volume 34, Issue 2, Page(s) 657–660

Abstract: ... This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome ... acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and ... constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1 ...

Abstract	Patients with 47, XXY karyotype (Klinefelter syndrome) appear to have increased risk of developing cancer, especially male breast cancer, germ cell tumours and non Hodgkin lymphomas, but rarely acute myeloid leukaemia. We report a patient with acute basophilic leukaemia with 47, XXY karyotype in both the tumour and constitutional cells. Acute basophilic leukaemia is very rare disease comprising less than 1% of all acute myeloid leukaemias. Morphological characteristic of leukaemic blast cells is moderately basophilic cytoplasm containing a variable number of coarse basophilic granules. The most characteristic cytochemical reaction is metachromatic positivity with toluidine blue. Blast are myeloperoxidase negative. Also leukemic blasts express myeloid and monocyte markers. There is no consistent chromosomal abnormality identified in this leukaemia. This is the first reported case of acute basophilic leukaemia in patient with Klinefelter syndrome. In this article the medical history of the patient is given and the possible connection between Klinefelter syndrome and acute myeloid leukaemia is discussed.
MeSH term(s)	Blast Crisis ; Bone Marrow Cells/pathology ; Chromosome Aberrations ; Chromosome Mapping ; Fatal Outcome ; Humans ; Karyotyping ; Klinefelter Syndrome/complications ; Klinefelter Syndrome/genetics ; Klinefelter Syndrome/pathology ; Leukemia, Basophilic, Acute/complications ; Leukemia, Basophilic, Acute/genetics ; Leukemia, Basophilic, Acute/pathology ; Male ; Middle Aged ; Multiple Organ Failure/pathology
Language	English
Publishing date	2010-06
Publishing country	Croatia
Document type	Case Reports ; Journal Article
ZDB-ID	233430-6
ISSN	0350-6134 ; 0353-3735
ISSN	0350-6134 ; 0353-3735
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Zs.A 5757: Show issues

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Article: [Acute basophilic leukemia: a case report].

Iehara, K / Tashiro, E / Ashihara, E / Okawa, K / Oku, N / Goto, H / Inaba, T / Ito, K / Fujita, N / Shimazaki, C

Rinsho ketsueki] The Japanese journal of clinical hematology

1993 Volume 34, Issue 7, Page(s) 847–852

Abstract: ... in March, 1990. This is the fifteenth case of acute basophilic leukemia reported in Japan, and ... IL-3. She was diagnosed as acute basophilic leukemia and treated with BHAC-DMP and B triple-V regimen ... by toluidine blue, contained basophilic granules in electron microscopic examination and reacted to G-CSF, G-CSF and ...

Abstract	A 56-year-old woman was admitted to our hospital in January, 1990 because of fever and petechiae. Leukocyte count of peripheral blood showed 41,000/microliters with 89% immature cells, and bone marrow was normocellular with 96.2% immature cells. They were medium to large in size, positive for peroxidase staining, CD-13 and CD-33. Half of them contained azurophilic granules. They showed metachromasia by toluidine blue, contained basophilic granules in electron microscopic examination and reacted to G-CSF, G-CSF and IL-3. She was diagnosed as acute basophilic leukemia and treated with BHAC-DMP and B triple-V regimen, but remission was not attained. She died of peritonitis due to gastrointestinal tract perforation and pneumonia in March, 1990. This is the fifteenth case of acute basophilic leukemia reported in Japan, and the hematological examinations performed in this patient were demonstrated.
MeSH term(s)	Bone Marrow/pathology ; Female ; Granulocyte Colony-Stimulating Factor/pharmacology ; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology ; Humans ; Interleukin-3/pharmacology ; Leukemia, Basophilic, Acute/blood ; Leukemia, Basophilic, Acute/diagnosis ; Middle Aged ; Tumor Cells, Cultured/pathology
Chemical Substances	Interleukin-3 ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
Language	Japanese
Publishing date	1993-07
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
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Article: Acute basophilic leukemia. A case report.

Kuo, C Y / Huang, M J / Chen, W J

Changgeng yi xue za zhi

1991 Volume 14, Issue 3, Page(s) 202–207

Abstract: A case of acute nonlymphocytic leukemia (ANLL) with primitive basophilic differentiation is ... could lead one to misclassify the case as lymphoid leukemia, but the characteristic finding of basophilic ... The cytochemical findings of this case suggested that basophilic differentiation should be considered when leukemic ...

Abstract	A case of acute nonlymphocytic leukemia (ANLL) with primitive basophilic differentiation is presented. The patient had no antecedent history or concomitant presence of chronic myelogenous leukemia. The leukemic blasts constituted 83% of the peripheral white blood cells and more than 90% of the marrow nucleated cells. Cytoplasmic vacuoles were found in some leukemic cells. About half the leukemic cells showed a few azurophilic granules stained with Wright's stain, whereas exhibited a faint pinkish hue around the cells without cytoplasmic granules (water-soluble granules) by Riu's stain. The cytoplasmic granules failed to be stained with peroxidase but stained positively with toluidine blue. The former result could lead one to misclassify the case as lymphoid leukemia, but the characteristic finding of basophilic cells in Riu's stain should direct one to make the diagnosis of ANLL with basophilic differentiation. The cytochemical findings of this case suggested that basophilic differentiation should be considered when leukemic cells show peroxidase-negative granules. Riu's stain and toluidine blue stain are useful to make the correct diagnosis.
MeSH term(s)	Adolescent ; Cytoplasmic Granules/enzymology ; Cytoplasmic Granules/ultrastructure ; Histamine Release ; Humans ; Leukemia, Basophilic, Acute/pathology ; Male ; Peroxidases/analysis
Chemical Substances	Peroxidases (EC 1.11.1.-)
Language	English
Publishing date	1991-09
Publishing country	China (Republic : 1949- )
Document type	Case Reports ; Journal Article
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Article: Acute promyelocytic leukemia presenting with atypical basophils.

Shameli, Afshin / Jamani, Kareem

Clinical case reports

2020 Volume 8, Issue 3, Page(s) 584–585

Abstract: We describe a case of acute promyelocytic leukemia with circulating aberrant basophils. Recent ... studies have shown that basophilic differentiation is not uncommon in APL and likely under-recognized ...

Abstract	We describe a case of acute promyelocytic leukemia with circulating aberrant basophils. Recent studies have shown that basophilic differentiation is not uncommon in APL and likely under-recognized in morphologic and immunophenotypic assessments.
Language	English
Publishing date	2020-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.2686
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Article: Acute Basophilic Leukemia Arising from Chronic Myeloid Leukemia with +8, I(17q)(q10) and der(22)t(9;22) After Imatinib Therapy.

Shan, Peng / Dong, Hang / Li, Shilan

Journal of blood medicine

2023 Volume 14, Page(s) 513–517

Abstract: Acute basophilic leukemia (ABL) arising from chronic myeloid leukemia (CML) with abundant ... in the prognosis of CML and trigger the development of complex karyotypes. Moreover, this is the first case report ... mast cells (MCs), coexisting with a complex karyotype is rare. Here, we report an 81-year-old man admitted ...

Abstract	Acute basophilic leukemia (ABL) arising from chronic myeloid leukemia (CML) with abundant mast cells (MCs), coexisting with a complex karyotype is rare. Here, we report an 81-year-old man admitted to our hospital with a history of ABL. He was diagnosed with CML in the chronic phase in January 2018, and Imatinib was used at a daily dose of 400mg. Then, transformation to ABL with abundant MCs in the bone marrow and complex karyotypes including 48,XY, trisomy 8 (+8), isochromosome 17(q10) [i(17)(q10)], and derivative chromosome 22 t(9;22) [der(22)t(9;22)] were discovered simultaneously in January 2022. In conclusion, the increased number of MCs in our case is a reminder that they might play an important role in the prognosis of CML and trigger the development of complex karyotypes. Moreover, this is the first case report of ABL arising from CML with abundant MCs, coexisting with 48,XY, +8, i(17)(q10), and der(22)t(9;22), during Imatinib treatment. Further studies are needed to better characterize this rare condition.
Language	English
Publishing date	2023-09-06
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2587464-0
ISSN	1179-2736
ISSN	1179-2736
DOI	10.2147/JBM.S412837
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