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Article: Kidney Transplantation in COVID Pandemic-A Review of Guidelines.

Gut, Gabriela / Góral, Agata / Dal Canton, Zofia / Poznański, Paweł / Krajewska, Magdalena / Kusztal, Mariusz

2021 Volume 10, Issue 13

Abstract: The paper describes problems with the transplantation process during the COVID-19 pandemic ... surgery. COVID-19 symptoms and risks of the transplant population are described. Detailed guidelines ... Transplantation procedures and programs have been impacted by COVID-19. The number of transplants has fallen ...

Abstract	The paper describes problems with the transplantation process during the COVID-19 pandemic. Transplantation procedures and programs have been impacted by COVID-19. The number of transplants has fallen noticeably. The first part of the paper points out changes in service organization, in particular donor and recipient pre-transplant and peri-transplant management. If the patients during pre-transplant evaluation need to attend face-to-face appointments, such as blood testing or other investigations, the risk of contracting or spreading COVID-19 should be minimized. "Clear green areas", which are COVID-19-free pathways, are highly recommended in hospitals during transplant procedures. Diagnostic procedures concerning donors, including CT scans and coronavirus testing (nasopharyngeal swab), are necessary before transplant surgery. COVID-19 symptoms and risks of the transplant population are described. Detailed guidelines from transplant societies concerning changes in immunosuppression in infected recipients are discussed. Management of infected or suspected medical staff is mentioned. The paper ends with guidelines concerning vaccination against COVID-19 in transplant recipients.
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10132877
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Article ; Online: Kidney Transplantation in COVID Pandemic—A Review of Guidelines

Gabriela Gut / Agata Góral / Zofia Dal Canton / Paweł Poznański / Magdalena Krajewska / Mariusz Kusztal

Journal of Clinical Medicine, Vol 10, Iss 2877, p

2021 Volume 2877

Abstract	The paper describes problems with the transplantation process during the COVID-19 pandemic. Transplantation procedures and programs have been impacted by COVID-19. The number of transplants has fallen noticeably. The first part of the paper points out changes in service organization, in particular donor and recipient pre-transplant and peri-transplant management. If the patients during pre-transplant evaluation need to attend face-to-face appointments, such as blood testing or other investigations, the risk of contracting or spreading COVID-19 should be minimized. “Clear green areas”, which are COVID-19-free pathways, are highly recommended in hospitals during transplant procedures. Diagnostic procedures concerning donors, including CT scans and coronavirus testing (nasopharyngeal swab), are necessary before transplant surgery. COVID-19 symptoms and risks of the transplant population are described. Detailed guidelines from transplant societies concerning changes in immunosuppression in infected recipients are discussed. Management of infected or suspected medical staff is mentioned. The paper ends with guidelines concerning vaccination against COVID-19 in transplant recipients.
Keywords	COVID-19 ; renal transplantation guidelines ; SARS-CoV-2 ; solid organ transplantation guidelines ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Global trends in chronic kidney disease-related mortality: a systematic review protocol.

Tungsanga, Somkanya / Ghimire, Anukul / Hariramani, Vinash K / Abdulrahman, Abdullah / Khan, Ana S / Ye, Feng / Kung, Janice Y / Klarenbach, Scott / Thompson, Stephanie / Collister, David / Srisawat, Nattachai / Okpechi, Ikechi G / Bello, Aminu K

BMJ open

2024 Volume 14, Issue 4, Page(s) e078485

Abstract: ... to kidney replacement therapies (dialysis and transplantation). The recent COVID-19 pandemic also affected mortality over the past ... Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search electronic databases ... temporal trends in the mortality rate associated with the COVID-19 pandemic.: Methods and analysis ...

Abstract	Introduction: In recent decades, all-cause mortality has increased among individuals with chronic kidney disease (CKD), influenced by factors such as aetiology, standards of care and access to kidney replacement therapies (dialysis and transplantation). The recent COVID-19 pandemic also affected mortality over the past few years. Here, we outline the protocol for a systematic review to investigate global temporal trends in all-cause mortality among patients with CKD at any stage from 1990 to current. We also aim to assess temporal trends in the mortality rate associated with the COVID-19 pandemic. Methods and analysis: We will conduct a systematic review of studies reporting mortality for patients with CKD following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search electronic databases, national and multiregional kidney registries and grey literature to identify observational studies that reported on mortality associated with any cause for patients with CKD of all ages with any stage of the disease. We will collect data between April and August 2023 to include all studies published from 1990 to August 2023. There will be no language restriction, and clinical trials will be excluded. Primary outcome will be temporal trends in CKD-related mortality. Secondary outcomes include assessing mortality differences before and during the COVID-19 pandemic, exploring causes of death and examining trends across CKD stages, country classifications, income levels and demographics. Ethics and dissemination: A systematic review will analyse existing data from previously published studies and have no direct involvement with patient data. Thus, ethical approval is not required. Our findings will be published in an open-access peer-reviewed journal and presented at scientific conferences. Prospero registration number: CRD42023416084.
MeSH term(s)	Humans ; Pandemics ; Renal Dialysis/adverse effects ; Systematic Reviews as Topic ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/etiology ; COVID-19/complications ; Research Design
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-078485
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Article: Literature review on COVID-19 vaccine efficacy in the immunocompromised population, and possible implications to future vaccination in kidney transplant patients.

Park, Joo Kyung / Bhandari, Sunil

Frontiers in medicine

2023 Volume 10, Page(s) 1103699

Abstract: ... updates to COVID-19 guidelines is necessary. ... of these virulent strains in this population. Specifically, this review aims to focus on kidney transplant ... 2019 (COVID-19) pandemic have been made globally. The development of the coronavirus disease (COVID ...

Abstract	Since the emergence of the virulent coronavirus in 2019, efforts to tackle the coronavirus-disease-2019 (COVID-19) pandemic have been made globally. The development of the coronavirus disease (COVID) vaccine was a significant breakthrough in ways to tackle the virus. Various research studies have been conducted to identify how the virus works and ways to manage COVID, including the efficacy of the vaccines. However, there is limited data on how these measures work for the immunocompromised, despite the grave impact of these virulent strains in this population. Specifically, this review aims to focus on kidney transplant recipients (KTRs). Studies have suggested that there is significantly lower vaccine response in some immunocompromised groups despite additional booster doses, and hence warrants an augmented or alternative protection against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for these patients. This suggests a need for alternative or more tailored approach in providing adequate protection against the COVID-19 in these cohorts. Some suggested ways include withholding immunosuppressants before and/or after vaccination, increasing the vaccine doses or reducing intervals and providing a mixture of monoclonal antibody (mAb) or antiviral therapy. However, the appropriate degree of alteration and augmentation, as well as its safety and effectiveness remains to be determined. Furthermore, continuous emergence of more virulent strains, such as the Omicron and its sub-lineages or the Deltacron, emphasises the need for ongoing research to assess the effectiveness of the current treatment against these new variants. Overall, active interest and appropriate updates to COVID-19 guidelines is necessary.
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1103699
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Article ; Online: Corona, COVID and kidney transplantation

Manisha Sahay / Vivek Kute / Narayan Prasad

Indian Journal of Transplantation, Vol 14, Iss 1, Pp 1-

2020 Volume 4

Abstract: ... virus disease (COVID-19). Many organizations have given guidelines for the prevention of COVID-19 ... Other societies have given updates regarding living and deceased donor transplantation during the pandemic ... transplantation. ...

Abstract	Severe acute respiratory syndrome corona virus 2 (SARS CoV2) is responsible for corona virus disease (COVID-19). Many organizations have given guidelines for the prevention of COVID-19. Other societies have given updates regarding living and deceased donor transplantation during the pandemic. This article reviews the literature available on corona virus and its impact on living and deceased donor transplantation.
Keywords	corona virus ; covid-19 ; pandemic ; transplntation ; Surgery ; RD1-811 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Corona, COVID and kidney transplantation

Sahay, Manisha / Kute, Vivek / Prasad, Narayan

Indian J. Transplant.

Abstract	Severe acute respiratory syndrome corona virus 2 (SARS CoV2) is responsible for corona virus disease (COVID-19). Many organizations have given guidelines for the prevention of COVID-19. Other societies have given updates regarding living and deceased donor transplantation during the pandemic. This article reviews the literature available on corona virus and its impact on living and deceased donor transplantation.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #71447
Database	COVID19

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Article: COVID-19 and the Response of Transplant Centers: the Global Response with an Emphasis on the Kidney Recipient.

Azzi, Yorg / Brooks, Abigail / Yaffe, Hillary / Greenstein, Stuart

Current transplantation reports

2021 Volume 8, Issue 3, Page(s) 163–182

Abstract: ... transplant centers enacted new guidelines. We approach this review by looking at how different transplant ... Purpose of the review: In response to the COVID-19 pandemic, vulnerable populations ... immunosuppressant regiments, and implement telemedicine. The kidney recipient population can be effectively managed ...

Abstract	Purpose of the review: In response to the COVID-19 pandemic, vulnerable populations, such as transplant patients, were at greater risk than the regular population. In order to protect these populations, transplant centers enacted new guidelines. We approach this review by looking at how different transplant regions responded to COVID-19 and analyze the unifying themes that have proven invaluable in the subsequent waves. Recent findings: We noticed that most elective surgeries including living donor transplant operations were suspended in most countries. The response to deceased donor transplants varied between countries: in some deceased donor transplants continued with modified donor and recipient criteria, while in other countries this surgery was suspended. There was a general trend of decreasing or holding antimetabolites, treating the virus with hydroxychloroquine and/or azithromycin, and converting outpatient clinics to virtual clinics. Summary: We learned how to carefully select donors and recipients, tailor immunosuppressant regiments, and implement telemedicine. The kidney recipient population can be effectively managed in times of crisis with appropriate accommodations and measures. This review can be a model for the transplant community for future pandemics.
Language	English
Publishing date	2021-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2196-3029
ISSN	2196-3029
DOI	10.1007/s40472-021-00330-5
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Article: Acute Kidney Injury Associated with Coronavirus Disease 2019 - One Year Later, What Do We Know So Far?

Gharge, Ankita / Nayak-Rao, Shobhana

Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia

2022 Volume 32, Issue 6, Page(s) 1543–1551

Abstract: ... some useful insights, we will know more going forward about the nature of kidney injury associated with COVID ... Initial reports early on in the pandemic in 2020 indicate a high incidence of acute kidney ... of the kidney also points toward the direct cytotoxic effects of the virus on the kidney. Numerous mechanisms ...

Abstract	Initial reports early on in the pandemic in 2020 indicate a high incidence of acute kidney injury (AKI) in coronavirus disease 2019 (COVID-19). There is a need to better understand risk factors for AKI in patients with COVID-19. It is also unclear if AKI in patients with COVID-19 differs from AKI due to other causes. More data are required to clarify if COVID-19 is an independent risk factor for AKI and how COVID-19-associated AKI may differ from AKI due to other causes. We, therefore, sought to review the published evidence about the reported relationship between COVID-19, AKI, and outcomes. We performed a systematic search via PubMed and EMBASE using key words "COVID-19" and "AKI" to identify relevant observational studies, case series, and cohort studies published between March 2020 and April 2021. We also manually examined the reference lists of included studies and reviewed the AKI reports published in general medicine journals such as BMJ, Lancet, NEJM, and JAMA. The prevalence of AKI in hospitalized patients with COVID-19 differed across various regions of the world. Initial reports from China where cases of COVID-19 began initially have shown a much lower prevalence compared to those from Europe and North America, especially in critically ill patients in the intensive care unit with acute respiratory distress syndrome. The various components of severe acute respiratory syndrome-associated AKI appear in large parts to be similar to sepsis-induced AKI. However, affinity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically to the angiotensin-converting enzyme 2 receptors located on podocytes and endothelial cells of the kidney also points toward the direct cytotoxic effects of the virus on the kidney. Numerous mechanisms likely occur simultaneously and hence more treatment approaches need to be streamlined based on pathophysiology. Although data from published literature regarding previous SARS coronaviruses can give some useful insights, we will know more going forward about the nature of kidney injury associated with COVID-19 virus as well as optimum-specific therapeutic management.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; COVID-19/complications ; COVID-19/epidemiology ; Endothelial Cells ; Humans ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2022-08-10
Publishing country	Saudi Arabia
Document type	Journal Article ; Review
ZDB-ID	1379955-1
ISSN	1319-2442
ISSN	1319-2442
DOI	10.4103/1319-2442.352414
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Article ; Online: COVID-19 in kidney transplant recipients: A multicenter experience in Istanbul.

Demir, Erol / Uyar, Murathan / Parmaksiz, Ergun / Sinangil, Ayse / Yelken, Berna / Dirim, Ahmet Burak / Merhametsiz, Ozgur / Yadigar, Serap / Atan Ucar, Zuhal / Ucar, Ali Riza / Demir, Mehmet Emin / Mese, Meral / Akin, Emin Baris / Garayeva, Nurana / Safak, Seda / Oto, Ozgur Akin / Yazici, Halil / Turkmen, Aydin

Transplant infectious disease : an official journal of the Transplantation Society

2020 Volume 22, Issue 5, Page(s) e13371

Abstract: Introduction: Management of COVID-19 in kidney transplant recipients should include treatment ... on this issue yet. This study aimed to our experiences with kidney transplant recipients diagnosed with COVID-19 ... Material and methods: Kidney transplant recipients diagnosed with COVID-19 from five major transplant ...

Abstract	Introduction: Management of COVID-19 in kidney transplant recipients should include treatment of the infection, regulation of immunosuppression, and supportive therapy. However, there is no consensus on this issue yet. This study aimed to our experiences with kidney transplant recipients diagnosed with COVID-19. Material and methods: Kidney transplant recipients diagnosed with COVID-19 from five major transplant centers in Istanbul, Turkey, were included in this retrospective cohort study. Patients were classified as having moderate or severe pneumonia for the analysis. The primary endpoint was all-cause mortality. The secondary endpoints were acute kidney injury, the average length of hospital stay, admission to intensive care, and mechanical ventilation. Results: Forty patients were reviewed retrospectively over a follow-up period of 32 days after being diagnosed with COVID-19. Cough, fever, and dyspnea were the most frequent symptoms in all patients. The frequency of previous induction and rejection therapy was significantly higher in the group with severe pneumonia compared to the moderate pneumonia group. None of the patients using cyclosporine A developed severe pneumonia. Five patients died during follow-up in the intensive care unit. None of the patients developed graft loss during follow-up. Discussion: COVID-19 has been seen to more commonly cause moderate or severe pneumonia in kidney transplant recipients. Immunosuppression should be carefully reduced in these patients. Induction therapy with lymphocyte-depleting agents should be carefully avoided in kidney transplant recipients during the pandemic period.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/therapy ; COVID-19 Nucleic Acid Testing ; Critical Care/methods ; Critical Care/standards ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/standards ; Female ; Follow-Up Studies ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunosuppression Therapy/adverse effects ; Immunosuppression Therapy/methods ; Immunosuppression Therapy/standards ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Intensive Care Units/standards ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Patient Admission/standards ; Practice Guidelines as Topic ; Respiration, Artificial/standards ; Retrospective Studies ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Transplant Recipients ; Treatment Outcome ; Turkey
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Immunosuppressive Agents ; Interleukin 1 Receptor Antagonist Protein ; tocilizumab (I031V2H011)
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	Denmark
Document type	Journal Article ; Multicenter Study
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13371
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Zs.A 5100: Show issues

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Article ; Online: Literature review on COVID-19 vaccine efficacy in the immunocompromised population, and possible implications to future vaccination in kidney transplant patients

Joo Kyung Park / Sunil Bhandari

Frontiers in Medicine, Vol

2023 Volume 10

Abstract	Since the emergence of the virulent coronavirus in 2019, efforts to tackle the coronavirus-disease-2019 (COVID-19) pandemic have been made globally. The development of the coronavirus disease (COVID) vaccine was a significant breakthrough in ways to tackle the virus. Various research studies have been conducted to identify how the virus works and ways to manage COVID, including the efficacy of the vaccines. However, there is limited data on how these measures work for the immunocompromised, despite the grave impact of these virulent strains in this population. Specifically, this review aims to focus on kidney transplant recipients (KTRs). Studies have suggested that there is significantly lower vaccine response in some immunocompromised groups despite additional booster doses, and hence warrants an augmented or alternative protection against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for these patients. This suggests a need for alternative or more tailored approach in providing adequate protection against the COVID-19 in these cohorts. Some suggested ways include withholding immunosuppressants before and/or after vaccination, increasing the vaccine doses or reducing intervals and providing a mixture of monoclonal antibody (mAb) or antiviral therapy. However, the appropriate degree of alteration and augmentation, as well as its safety and effectiveness remains to be determined. Furthermore, continuous emergence of more virulent strains, such as the Omicron and its sub-lineages or the Deltacron, emphasises the need for ongoing research to assess the effectiveness of the current treatment against these new variants. Overall, active interest and appropriate updates to COVID-19 guidelines is necessary.
Keywords	COVID-19 ; kidney transplant ; hemodialysis ; immunocompromised ; vaccination ; efficacy ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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