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Article ; Online: Advances in on-chip vascularization.

Haase, Kristina / Kamm, Roger D

2017 Volume 12, Issue 3, Page(s) 285–302

Abstract: Microfluidics is invaluable for studying microvasculature, development of organ-on-chip models and ... vascular networks are generated by two distinct approaches: via endothelial-lined patterned channels, or ... vasculogenesis and cancer metastasis. Various techniques are employed in order to generate rapid perfusion ...

Abstract	Microfluidics is invaluable for studying microvasculature, development of organ-on-chip models and engineering microtissues. Microfluidic design can cleverly control geometry, biochemical gradients and mechanical stimuli, such as shear and interstitial flow, to more closely mimic in vivo conditions. In vitro vascular networks are generated by two distinct approaches: via endothelial-lined patterned channels, or by self-assembled networks. Each system has its own benefits and is amenable to the study of angiogenesis, vasculogenesis and cancer metastasis. Various techniques are employed in order to generate rapid perfusion of these networks within a variety of tissue and organ-mimicking models, some of which have shown recent success following implantation in vivo. Combined with tuneable hydrogels, microfluidics holds great promise for drug screening as well as in the development of prevascularized tissues for regenerative medicine.
MeSH term(s)	Animals ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Humans ; Lab-On-A-Chip Devices ; Microfluidic Analytical Techniques/methods ; Neoplasms/blood supply ; Neoplasms/metabolism ; Neoplasms/pathology ; Neovascularization, Pathologic/metabolism ; Neovascularization, Pathologic/pathology ; Neovascularization, Physiologic
Language	English
Publishing date	2017-03-20
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2274500-2
ISSN	1746-076X ; 1746-0751
ISSN (online)	1746-076X
ISSN	1746-0751
DOI	10.2217/rme-2016-0152
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Article: Recent advances in vascularized tumor-on-a-chip.

Huang, Christina Bao Xian / Tu, Ting-Yuan

Frontiers in oncology

2023 Volume 13, Page(s) 1150332

Abstract: ... aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has ...

Abstract	The vasculature plays a critical role in cancer progression and metastasis, representing a pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on-a-chip technology has proven to be a robust tool, capable of replicating
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1150332
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Article ; Online: Advances in

Sevinc Ozdemir, Neval / Belyaev, Dmitry / Castro, Manuel Nieto / Balakin, Sascha / Opitz, Joerg / Wihadmadyatami, Hevi / Anggraeni, Rahmi / Yucel, Deniz / Kenar, Halime / Beshchasna, Natalia / Ana, Ika Dewi / Hasirci, Vasif

Tissue engineering. Part B, Reviews

2023 Volume 30, Issue 1, Page(s) 82–96

Abstract: ... tissue engineered models, and organ-on-a-chip systems, which aim to better imitate the infection site ...

Abstract	Respiratory infections caused by coronaviruses (CoVs) have become a major public health concern in the past two decades as revealed by the emergence of SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The most severe clinical phenotypes commonly arise from exacerbation of immune response following the infection of alveolar epithelial cells localized at the pulmonary blood-air barrier. Preclinical rodent models do not adequately represent the essential genetic properties of the barrier, thus necessitating the use of humanized transgenic models. However, existing monolayer cell culture models have so far been unable to mimic the complex lung microenvironment. In this respect, air-liquid interface models, tissue engineered models, and organ-on-a-chip systems, which aim to better imitate the infection site microenvironment and microphysiology, are being developed to replace the commonly used monolayer cell culture models, and their use is becoming more widespread every day. On the contrary, studies on the development of nanoparticles (NPs) that mimic respiratory viruses, and those NPs used in therapy are progressing rapidly. The first part of this review describes
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Blood-Air Barrier ; Middle East Respiratory Syndrome Coronavirus ; Nanoparticles
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2420584-9
ISSN	1937-3376 ; 1937-3368
ISSN (online)	1937-3376
ISSN	1937-3368
DOI	10.1089/ten.TEB.2023.0117
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Article: Advances in 3D Vascularized Tumor-on-a-Chip Technology.

Jung, Sangmin / Jo, Hyeonsu / Hyung, Sujin / Jeon, Noo Li

Advances in experimental medicine and biology

2022 Volume 1379, Page(s) 231–256

Abstract: ... are important to developing anti-cancer therapies. Tumor-on-a-chip technology can be applied ... effectiveness. Herein, we explore the ability of tumor-on-a-chip technology to mimic angiogenic and ... angiogenesis and lymphangiogenesis. Moreover, we present future applications of emerging tumor-on-a-chip ...

Abstract	Tumors disrupt the normal homeostasis of human body as they proliferate in abnormal speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients and oxygen. Immune system simultaneously recruits lymphatic vessels to induce the death of tumor cells. Hence, understanding tumor dynamics are important to developing anti-cancer therapies. Tumor-on-a-chip technology can be applied to identify the structural and functional units of tumors and tumor microenvironments with high reproducibility and reliability, monitoring the development and pathophysiology of tumors, and predicting drug effectiveness. Herein, we explore the ability of tumor-on-a-chip technology to mimic angiogenic and lymphangiogenic tumor microenvironments of organs. Microfluidic systems allow elaborate manipulation of the development and status of cancer. Therefore, they can be used to validate the effects of various drug combinations, specify them, and assess the factors that influence cancer treatment. We discuss the mechanisms of action of several drugs for cancer treatment in terms of tumor growth and progression involving angiogenesis and lymphangiogenesis. Moreover, we present future applications of emerging tumor-on-a-chip technology for drug development and cancer therapy.
MeSH term(s)	Humans ; Lab-On-A-Chip Devices ; Microfluidics ; Neoplasms/drug therapy ; Neoplasms/pathology ; Reproducibility of Results ; Tumor Microenvironment
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-031-04039-9_9
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Article: Neurovascular unit on a chip: the relevance and maturity as an advanced in vitro model.

Palma-Florez, Sujey / Lagunas, Anna / Mir, Mònica

Neural regeneration research

2023 Volume 19, Issue 6, Page(s) 1165–1166

Language	English
Publishing date	2023-09-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.385863
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Article ; Online: Recent Advances in Electrochemical Detection of Cell Energy Metabolism.

Koo, Kyeong-Mo / Kim, Chang-Dae / Kim, Tae-Hyung

Biosensors

2024 Volume 14, Issue 1

Abstract: ... mitochondrial metabolites, along with their many applications in cell chips and wearable sensors. ... and neurodegenerative and cardiovascular disorders. As a result, altered metabolites hold value ...

Abstract	Cell energy metabolism is a complex and multifaceted process by which some of the most important nutrients, particularly glucose and other sugars, are transformed into energy. This complexity is a result of dynamic interactions between multiple components, including ions, metabolic intermediates, and products that arise from biochemical reactions, such as glycolysis and mitochondrial oxidative phosphorylation (OXPHOS), the two main metabolic pathways that provide adenosine triphosphate (ATP), the main source of chemical energy driving various physiological activities. Impaired cell energy metabolism and perturbations or dysfunctions in associated metabolites are frequently implicated in numerous diseases, such as diabetes, cancer, and neurodegenerative and cardiovascular disorders. As a result, altered metabolites hold value as potential disease biomarkers. Electrochemical biosensors are attractive devices for the early diagnosis of many diseases and disorders based on biomarkers due to their advantages of efficiency, simplicity, low cost, high sensitivity, and high selectivity in the detection of anomalies in cellular energy metabolism, including key metabolites involved in glycolysis and mitochondrial processes, such as glucose, lactate, nicotinamide adenine dinucleotide (NADH), reactive oxygen species (ROS), glutamate, and ATP, both in vivo and in vitro. This paper offers a detailed examination of electrochemical biosensors for the detection of glycolytic and mitochondrial metabolites, along with their many applications in cell chips and wearable sensors.
MeSH term(s)	Energy Metabolism ; Adenosine Triphosphate ; Glucose ; Lactic Acid ; Biomarkers
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Glucose (IY9XDZ35W2) ; Lactic Acid (33X04XA5AT) ; Biomarkers
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios14010046
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Article ; Online: Advances in cardiac tissue engineering and heart-on-a-chip.

Kieda, Jennifer / Shakeri, Amid / Landau, Shira / Wang, Erika Yan / Zhao, Yimu / Lai, Benjamin Fook / Okhovatian, Sargol / Wang, Ying / Jiang, Richard / Radisic, Milica

Journal of biomedical materials research. Part A

2023 Volume 112, Issue 4, Page(s) 492–511

Abstract: Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new ... with induced pluripotent stem cell-derived cardiac patches that advanced to human testing. Heart-on-a-chip platforms are now commonly ... fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately ...

Abstract	Recent advances in both cardiac tissue engineering and hearts-on-a-chip are grounded in new biomaterial development as well as the employment of innovative fabrication techniques that enable precise control of the mechanical, electrical, and structural properties of the cardiac tissues being modelled. The elongated structure of cardiomyocytes requires tuning of substrate properties and application of biophysical stimuli to drive its mature phenotype. Landmark advances have already been achieved with induced pluripotent stem cell-derived cardiac patches that advanced to human testing. Heart-on-a-chip platforms are now commonly used by a number of pharmaceutical and biotechnology companies. Here, we provide an overview of cardiac physiology in order to better define the requirements for functional tissue recapitulation. We then discuss the biomaterials most commonly used in both cardiac tissue engineering and heart-on-a-chip, followed by the discussion of recent representative studies in both fields. We outline significant challenges common to both fields, specifically: scalable tissue fabrication and platform standardization, improving cellular fidelity through effective tissue vascularization, achieving adult tissue maturation, and ultimately developing cryopreservation protocols so that the tissues are available off the shelf.
MeSH term(s)	Humans ; Tissue Engineering/methods ; Myocytes, Cardiac ; Biocompatible Materials ; Lab-On-A-Chip Devices ; Induced Pluripotent Stem Cells ; Myocardium
Chemical Substances	Biocompatible Materials
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2099989-6
ISSN	1552-4965 ; 1549-3296 ; 0021-9304
ISSN (online)	1552-4965
ISSN	1549-3296 ; 0021-9304
DOI	10.1002/jbm.a.37633
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Article ; Online: Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism.

Yoon, Heejeong / Sabaté Del Río, Jonathan / Cho, Seung Woo / Park, Tae-Eun

Lab on a chip

2024 Volume 24, Issue 5, Page(s) 1351–1366

Abstract: ... vascular conditions, all of which can be effectively examined using MPS. This review surveys the recent ...

Abstract	Tumor metastasis involves complex processes that traditional 2D cultures and animal models struggle to fully replicate. Metastatic tumors undergo a multitude of transformations, including genetic diversification, adaptation to diverse microenvironments, and modified drug responses, contributing significantly to cancer-related mortality. Micro-physiological systems (MPS) technology emerges as a promising approach to emulate the metastatic process by integrating critical biochemical, biomechanical, and geometrical cues at a microscale. These systems are particularly advantageous simulating metastasis organotropism, the phenomenon where tumors exhibit a preference for metastasizing to particular organs. Organotropism is influenced by various factors, such as tumor cell characteristics, unique organ microenvironments, and organ-specific vascular conditions, all of which can be effectively examined using MPS. This review surveys the recent developments in MPS research from the past five years, with a specific focus on their applications in replicating tumor metastasis and organotropism. Furthermore, we discuss the current limitations in MPS-based studies of organotropism and propose strategies for more accurately replicating and analyzing the intricate aspects of organ-specific metastasis, which is pivotal in the development of targeted therapeutic approaches against metastatic cancers.
MeSH term(s)	Animals ; Neoplasms ; Neoplasm Metastasis ; Tumor Microenvironment
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2056646-3
ISSN	1473-0189 ; 1473-0197
ISSN (online)	1473-0189
ISSN	1473-0197
DOI	10.1039/d3lc01033c
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Article ; Online: 3D Cell Printing of Advanced Vascularized Proximal Tubule-on-a-Chip for Drug Induced Nephrotoxicity Advancement.

Singh, Narendra K / Kim, Jae Yun / Jang, Jinah / Kim, Yong Kyun / Cho, Dong-Woo

ACS applied bio materials

2023 Volume 6, Issue 9, Page(s) 3750–3758

Abstract: ... induced kidney injury. Herein, a vascularized proximal tubule-on-a-chip (Vas-POAC) was fabricated ... worldwide. The vascularized proximal tubule is a complex structure that is often the primary site of drug ... model of vascularized proximal tubules permits the growth and proliferation of renal proximal tubule ...

Abstract	Renal dysfunction due to drug-induced nephrotoxicity (DIN) affects >20% of the adult population worldwide. The vascularized proximal tubule is a complex structure that is often the primary site of drug-induced kidney injury. Herein, a vascularized proximal tubule-on-a-chip (Vas-POAC) was fabricated, demonstrating improved physiological emulation over earlier single-cell proximal tubule models. A perfusable model of vascularized proximal tubules permits the growth and proliferation of renal proximal tubule cells and adjacent endothelial cells under various conditions. An
MeSH term(s)	Adult ; Humans ; Endothelial Cells ; Cisplatin/adverse effects ; Epithelial Cells ; Printing, Three-Dimensional ; Lab-On-A-Chip Devices
Chemical Substances	Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-6422
ISSN (online)	2576-6422
DOI	10.1021/acsabm.3c00421
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Article ; Online: Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications.

Wu, Hanbai / Shi, Shuo / Liu, Yi / Zhang, Qiang / Lam, Raymond H W / Lim, Chwee Teck / Hu, Jinlian

Biofabrication

2023 Volume 15, Issue 4

Abstract: ... we elaborate on various biomedical applications of these microfluidic systems such as blood-vessel-on-a-chip ... and heart-on-a-chip, which are conducive to the investigation of the underlying mechanisms of CVDs ... has been made to develop microfluidic systems to recapitulate native cardiovascular environments ...

Abstract	Cardiovascular diseases (CVDs) are a major cause of death worldwide, leading to increased medical care costs. To turn the scale, it is essential to acquire a more in-depth and comprehensive understanding of CVDs and thus formulate more efficient and reliable treatments. Over the last decade, tremendous effort has been made to develop microfluidic systems to recapitulate native cardiovascular environments because of their unique advantages over conventional 2D culture systems and animal models such as high reproductivity, physiological relevance, and good controllability. These novel microfluidic systems could be extensively adopted for natural organ simulation, disease modeling, drug screening, disease diagnosis and therapy. Here, a brief review of the innovative designs of microfluidic devices for CVDs research is presented, with specific discussions on material selection, critical physiological and physical considerations. In addition, we elaborate on various biomedical applications of these microfluidic systems such as blood-vessel-on-a-chip and heart-on-a-chip, which are conducive to the investigation of the underlying mechanisms of CVDs. This review also provides systematic guidance on the construction of next-generation microfluidic systems for the diagnosis and treatment of CVDs. Finally, the challenges and future directions in this field are highlighted and discussed.
MeSH term(s)	Animals ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/therapy ; Microphysiological Systems ; Microfluidics ; Lab-On-A-Chip Devices ; Heart
Language	English
Publishing date	2023-07-04
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2500944-8
ISSN	1758-5090 ; 1758-5082
ISSN (online)	1758-5090
ISSN	1758-5082
DOI	10.1088/1758-5090/acdaf9
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