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  1. Article ; Online: Role of extracorporeal membrane oxygenation in COVID-19: A systematic review.

    Haiduc, Ana Alina / Alom, Samiha / Melamed, Naomi / Harky, Amer

    Journal of cardiac surgery

    2020  Volume 35, Issue 10, Page(s) 2679–2687

    Abstract: ... extracorporeal membrane oxygenation in COVID-19 patients in a systematic review manner.: Methods: We conducted a systematic review ... keywords and MeSH terms to identify articles pertaining to extracorporeal membrane oxygenation (ECMO) and ... Coronavirus disease 2019 (COVID-19). A narrative synthesis was then undertaken to identify the key themes ...

    Abstract Objective: We aimed to examine the literature evidence behind using extracorporeal membrane oxygenation in COVID-19 patients in a systematic review manner.
    Methods: We conducted a systematic review using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was conducted on Global Health Medline, EMBASE, and Cochrane databases using keywords and MeSH terms to identify articles pertaining to extracorporeal membrane oxygenation (ECMO) and Coronavirus disease 2019 (COVID-19). A narrative synthesis was then undertaken to identify the key themes.
    Results: A total of 25 articles met the inclusion criteria of this systematic review. Three main themes were identified following the data extraction: (a) evidence against/inconclusive regarding ECMO for COVID-19, (b) evidence supporting ECMO for COVID-19, and finally (c) VV-ECMO and VA-ECMO. After combining the data, there were 3428 patients diagnosed with COVID-19 and 95 ECMO-associated deaths (19.83%).
    Conclusion: Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes. Although ECMO has been shown to be beneficial in a selected group of patients, the recuperative effects of ECMO remain inconclusive. We must ensure that risk-benefit analysis for each candidate is conducted thoroughly so that patients that have increased probability of survival can benefit from this scarce resource.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Extracorporeal Membrane Oxygenation/methods ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Role of extracorporeal membrane oxygenation in COVID-19: A systematic review

    Haiduc, Ana Alina / Alom, Samiha / Melamed, Naomi / Harky, Amer

    J Card Surg

    Abstract: ... extracorporeal membrane oxygenation in COVID-19 patients in a systematic review manner. METHODS: We conducted a systematic review ... keywords and MeSH terms to identify articles pertaining to extracorporeal membrane oxygenation (ECMO) and ... Coronavirus disease 2019 (COVID-19). A narrative synthesis was then undertaken to identify the key themes ...

    Abstract OBJECTIVE: We aimed to examine the literature evidence behind using extracorporeal membrane oxygenation in COVID-19 patients in a systematic review manner. METHODS: We conducted a systematic review using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A comprehensive literature search was conducted on Global Health Medline, EMBASE, and Cochrane databases using keywords and MeSH terms to identify articles pertaining to extracorporeal membrane oxygenation (ECMO) and Coronavirus disease 2019 (COVID-19). A narrative synthesis was then undertaken to identify the key themes. RESULTS: A total of 25 articles met the inclusion criteria of this systematic review. Three main themes were identified following the data extraction: (a) evidence against/inconclusive regarding ECMO for COVID-19, (b) evidence supporting ECMO for COVID-19, and finally (c) VV-ECMO and VA-ECMO. After combining the data, there were 3428 patients diagnosed with COVID-19 and 95 ECMO-associated deaths (19.83%). CONCLUSION: Our study highlights the paucity of evidence and the need for further data to consolidate the efficacy of ECMO in improving patient outcomes. Although ECMO has been shown to be beneficial in a selected group of patients, the recuperative effects of ECMO remain inconclusive. We must ensure that risk-benefit analysis for each candidate is conducted thoroughly so that patients that have increased probability of survival can benefit from this scarce resource.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #680252
    Database COVID19

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  3. Article ; Online: Role of extracorporeal membrane oxygenation in COVID19

    Haiduc, Ana Alina / Alom, Samiha / Melamed, Naomi / Harky, Amer

    Journal of Cardiac Surgery

    A systematic review

    2020  Volume 35, Issue 10, Page(s) 2679–2687

    Keywords Surgery ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 639059-6
    ISSN 1540-8191 ; 0886-0440
    ISSN (online) 1540-8191
    ISSN 0886-0440
    DOI 10.1111/jocs.14879
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Role of Invasive Mechanical Ventilation and ECMO in the Management of COVID-19: A Systematic Review.

    Nagraj, Sanjana / Karia, Rutu / Hassanain, Sahar / Ghosh, Prithwish / Shah, Viraj R / Thomas, Abin

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2021  Volume 25, Issue 6, Page(s) 691–698

    Abstract: ... of extracorporeal membrane oxygenation (ECMO) and invasive mechanical ventilation use in critically ill COVID-19 patients ... A. Role of Invasive Mechanical Ventilation and ECMO in the Management of COVID-19: A Systematic Review ... for published studies about ECMO and/or invasive mechanical ventilation use in COVID-19 patients. Data ...

    Abstract Objectives: This systematic review aims to provide insight into the outcome of extracorporeal membrane oxygenation (ECMO) and invasive mechanical ventilation use in critically ill COVID-19 patients.
    Data sources: Electronic databases PubMed Central and PubMed were searched from January 2020 to June 2020 for published studies about ECMO and/or invasive mechanical ventilation use in COVID-19 patients. Data Extraction and Study Selection: The search strategy retrieved 766 articles, of which 19 studies consisting of 204 patients fulfilled the inclusion criteria and were included in the analysis.
    Data synthesis: Primary outcomes evaluated were discharge and/or clinical improvement and mortality rate. Secondary outcomes evaluated included reported complications and the mean number of days of hospitalization for survivors. Weighted averages of included studies were calculated, and data were pooled in forest plots. Nearly, 68.1% of the patients received invasive mechanical ventilation without ECMO support, and 31.9% were placed on ECMO. Also, 22.5% of the patients were discharged and/or clinically improved and 51.5% died. Twenty-six percent of the study population deteriorated but remained alive or experienced no improvement in clinical condition. And 75.2% of those who died belonged to the non-ECMO group and 24.8% to the ECMO group. The mortality rate in the non-ECMO group was 56.8% compared to 40% in the ECMO group.
    Conclusion: The utility of ECMO during a pandemic is uncertain as it is a resource-intensive modality, especially when the mortality rate in severely ill patients infected with COVID-19 virus is already known to be high.
    How to cite this article: Nagraj S, Karia R, Hassanain S, Ghosh P, Shah VR, Thomas A. Role of Invasive Mechanical Ventilation and ECMO in the Management of COVID-19: A Systematic Review. Indian J Crit Care Med 2021;25(6):691-698.
    Language English
    Publishing date 2021-04-17
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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