Article: Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients.
2021 Volume 12, Page(s) 596518
Abstract: ... diabetes mellitus (T2DM) among COVID-19 patients.: Design and methods: In this retrospective study, the clinical ... and immunological characteristics of 306 hospitalized confirmed COVID-19 patients (including 129 ... the effect of type 2 diabetes (T2DM) or hyperglycemia on the immune system among COVID-19 disease has ...
| Abstract | Clinical trial registration: www.ClinicalTrials.gov, identifier: NCT04365634. Context: Diabetes mellitus was associated with increased severity and mortality of disease in COVID-19 pneumonia. So far the effect of type 2 diabetes (T2DM) or hyperglycemia on the immune system among COVID-19 disease has remained unclear. Objective: We aim to explore the clinical and immunological features of type 2 diabetes mellitus (T2DM) among COVID-19 patients. Design and methods: In this retrospective study, the clinical and immunological characteristics of 306 hospitalized confirmed COVID-19 patients (including 129 diabetic and 177 non-diabetic patients) were analyzed. The serum concentrations of laboratory parameters including cytokines and numbers of immune cells were measured and compared between diabetic and non-diabetic groups. Results: Compared with non-diabetic group, diabetic cases more frequently had lymphopenia and hyperglycemia, with higher levels of urea nitrogen, myoglobin, D-dimer and ferritin. Diabetic cases indicated the obviously elevated mortality and the higher levels of cytokines IL-2R, IL-6, IL-8, IL-10, and TNF-α, as well as the distinctly reduced Th1/Th2 cytokines ratios compared with non-diabetic cases. The longitudinal assays showed that compared to that at week 1, the levels of IL-6 and IL-8 were significantly elevated at week 2 after admission in non-survivors of diabetic cases, whereas there were greatly reductions from week 1 to week 2 in survivors of diabetic cases. Compared with survival diabetic patients, non-survival diabetic cases displayed distinct higher serum concentrations of IL-2R, IL-6, IL-8, IL-10, TNF-α, and lower Th1/Th2 cytokines ratios at week 2. Samples from a subset of participants were evaluated by flow cytometry for the immune cells. The counts of peripheral total T lymphocytes, CD4 Conclusion: The elevated cytokines, imbalance of Th1/Th2 cytokines ratios and reduced of peripheral numbers of CD8 |
|---|---|
| MeSH term(s) | Adult ; Aged ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/pathology ; COVID-19/blood ; COVID-19/complications ; COVID-19/immunology ; COVID-19/mortality ; China/epidemiology ; Cytokines/analysis ; Cytokines/blood ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/immunology ; Diabetes Mellitus, Type 2/mortality ; Female ; Humans ; Hyperglycemia/blood ; Hyperglycemia/complications ; Hyperglycemia/immunology ; Hyperglycemia/mortality ; Immune System/metabolism ; Immune System/pathology ; Killer Cells, Natural/pathology ; Lymphocyte Count ; Lymphopenia/blood ; Lymphopenia/complications ; Lymphopenia/immunology ; Lymphopenia/mortality ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Th1 Cells/pathology ; Th2 Cells/pathology |
| Chemical Substances | Cytokines |
| Language | English |
| Publishing date | 2021-03-11 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2592084-4 |
| ISSN | 1664-2392 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2021.596518 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.