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  1. Article ; Online: Candida auris

    Hanson, Blake M / Dinh, An Q / Tran, Truc T / Arenas, Sebastian / Pronty, Darryl / Gershengorn, Hayley B / Ferreira, Tanira / Arias, Cesar A / Shukla, Bhavarth S

    Antimicrobial agents and chemotherapy

    2021  Volume 65, Issue 10, Page(s) e0114621

    Abstract: Clinical cases of C. auris noted during a COVID-19 surge led to an epidemiological, clinical, and ... all cases. Prolonged hospitalization due to critical illness from COVID-19 and use of antimicrobials ... may have contributed to clinical infections. ...

    Abstract Clinical cases of C. auris noted during a COVID-19 surge led to an epidemiological, clinical, and genomic investigation. Evaluation identified a close genetic relationship but inconclusive epidemiologic link between all cases. Prolonged hospitalization due to critical illness from COVID-19 and use of antimicrobials may have contributed to clinical infections.
    MeSH term(s) Antifungal Agents/therapeutic use ; COVID-19 ; Candida/genetics ; Candidiasis, Invasive/drug therapy ; Humans ; SARS-CoV-2
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2021-08-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01146-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Candida auris outbreak at a tertiary care hospital during the COVID-19 pandemic.

    Dbeibo, Lana / Beeler, Cole / Clark, Lauren / Zondor, Megan / Sartino, Catherine / Relich, Ryan F / Hazen, Dana / Lyons, Kathy / Kelley, Kristen / Webb, Douglas / Saysana, Michele / Kara, Areeba

    American journal of infection control

    2024  

    Abstract: ... outbreaks during the COVID-19 pandemic. In this report, we describe an outbreak of C auris, its control ... persistence leading to outbreaks in health care settings. There has been a worldwide surge in C auris ... and surveillance testing for C auris was obtained from patients who were exposed to the index case ...

    Abstract Background: Candida auris (C auris) is a fungal pathogen that has the potential for environmental persistence leading to outbreaks in health care settings. There has been a worldwide surge in C auris outbreaks during the COVID-19 pandemic. In this report, we describe an outbreak of C auris, its control, patient outcomes, and lessons learned.
    Methods: The outbreak occurred in a 600-bed adult academic tertiary care hospital. Contact tracing was initiated immediately after identification of the index case and surveillance testing for C auris was obtained from patients who were exposed to the index case. Infection prevention measures were closely followed.
    Results: A total of 560 cultures were performed on 453 unique patients between August 2021 and December 2021. Of those, 31 cultures (5.5%) were positive for C auris; 27 (87.1%) were colonized with C auris, while 4 patients developed a clinical infection (12.9%). The secondary attack rate was 6.8% (31/453). The 30-day all-cause mortality rate for all patients who tested positive for C auris was 9.7%.
    Discussion: C auris can cause protracted outbreaks that result in colonization and invasive infections. Multidisciplinary work to improve adherence to infection prevention measures as well as targeted admission screening are essential to limit outbreaks.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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