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  1. Article ; Online: Artemisia annua: Trials are needed for COVID-19.

    Haq, Faiz Ul / Roman, Muhammad / Ahmad, Kashif / Rahman, Saeed Ur / Shah, Syed Murtaza Ali / Suleman, Naveed / Ullah, Sami / Ahmad, Iftekhar / Ullah, Wajahat

    Phytotherapy research : PTR

    2020  Volume 34, Issue 10, Page(s) 2423–2424

    Keywords covid19
    Language English
    Publishing date 2020-05-27
    Publishing country England
    Document type Letter
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.6733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Artemisia annua: Trials are needed for COVID-19

    Haq, Faiz Ul / Roman, Muhammad / Ahmad, Kashif / Rahman, Saeed Ur / Shah, Syed Murtaza Ali / Suleman, Naveed / Ullah, Sami / Ahmad, Iftekhar / Ullah, Wajahat

    Phytother Res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #306152
    Database COVID19

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  3. Article ; Online: Artemisia annua

    Haq, Faiz Ul / Roman, Muhammad / Ahmad, Kashif / Rahman, Saeed Ur / Shah, Syed Murtaza Ali / Suleman, Naveed / Ullah, Sami / Ahmad, Iftekhar / Ullah, Wajahat

    Phytotherapy Research ; ISSN 0951-418X 1099-1573

    Trials are needed for COVID ‐19

    2020  

    Keywords Pharmacology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1002/ptr.6733
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Artemisia Spp. derivatives for COVID-19 treatment

    Kapepula, Paulin M. / Kabengele, Jimmy K. / Kingombe, Micheline / Van Bambeke, Francoise / Tulkens, Paul M. / Kishabongo, Antoine Sadiki / Decloedt, Eric / Zumla, Adam / Tiberi, Simon / Suleman, Fatima / Tshilolo, Leon / Muyembe-TamFum, Jean-Jacques / Zumla, Alimuddin / Nachega, Jean B.

    anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials

    2020  

    Abstract: CITATION: Kapepula, P. M. et al. 2020. Artemisia Spp. derivatives for COVID-19 treatment ... through randomized controlled trials (RCTs) in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 ... available at https://www.ajtmh.org ...

    Abstract CITATION: Kapepula, P. M. et al. 2020. Artemisia Spp. derivatives for COVID-19 treatment : anecdotal use, political hype, treatment potential, challenges, and road map to randomized clinical trials. American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-0820.

    The original publication is available at https://www.ajtmh.org

    The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 continues. We have witnessed anecdotal use of herbal medicines, including Artemisia spp. extracts, in low-income countries, and exaggerated claims of their efficacies that are not evidence based, with subsequent political controversy. These events highlight the urgent need for further research on herbal compounds to evaluate efficacy through RCTs, and, when efficacious compounds are identified, to establish the active ingredients, develop formulations and dosing, and define pharmacokinetics, toxicology, and safety to enable drug development. Derivatives from the herb Artemisia annua have been used as traditional medicine over centuries for the treatment of fevers, malaria, and respiratory tract infections. We review the bioactive compounds, pharmacological and immunological effects, and traditional uses for Artemisia spp. derivatives, and discuss the challenges and controversies surrounding current efforts and the scientific road map to advance them to prevent or treat COVID-19.

    https://www.ajtmh.org/content/journals/10.4269/ajtmh.20-0820

    Publisher's version
    Keywords COVID-19 (Disease) ; Artemisia ; covid19
    Subject code 610
    Language English
    Publisher American Society of Tropical Medicine and Hygiene
    Publishing country za
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials

    Kapepula, Paulin M / Kabengele, Jimmy K / Kingombe, Micheline / Van Bambeke, Françoise / Tulkens, Paul M / Sadiki Kishabongo, Antoine / Decloedt, Eric / Zumla, Adam / Tiberi, Simon / Suleman, Fatima / Tshilolo, Léon / Muyembe-TamFum, Jean-Jacques / Zumla, Alimuddin / Nachega, Jean B

    Am J Trop Med Hyg

    Abstract: The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12 ... in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 continues. We have ... them to prevent or treat COVID-19. ...

    Abstract The world is currently facing a novel COVID-19 pandemic caused by SARS-CoV-2 that, as of July 12, 2020, has caused a reported 12,322,395 cases and 556,335 deaths. To date, only two treatments, remdesivir and dexamethasone, have demonstrated clinical efficacy through randomized controlled trials (RCTs) in seriously ill patients. The search for new or repurposed drugs for treatment of COVID-19 continues. We have witnessed anecdotal use of herbal medicines, including Artemisia spp. extracts, in low-income countries, and exaggerated claims of their efficacies that are not evidence based, with subsequent political controversy. These events highlight the urgent need for further research on herbal compounds to evaluate efficacy through RCTs, and, when efficacious compounds are identified, to establish the active ingredients, develop formulations and dosing, and define pharmacokinetics, toxicology, and safety to enable drug development. Derivatives from the herb Artemisia annua have been used as traditional medicine over centuries for the treatment of fevers, malaria, and respiratory tract infections. We review the bioactive compounds, pharmacological and immunological effects, and traditional uses for Artemisia spp. derivatives, and discuss the challenges and controversies surrounding current efforts and the scientific road map to advance them to prevent or treat COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #676291
    Database COVID19

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