Article ; Online: Light therapy and serotonin transporter binding in the anterior cingulate and prefrontal cortex.
Acta psychiatrica Scandinavica
2015 Volume 132, Issue 5, Page(s) 379–388
Abstract: Objective: To investigate the effects of light therapy on serotonin transporter binding (5-HTT ... to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would ... BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC ...
| Abstract | Objective: To investigate the effects of light therapy on serotonin transporter binding (5-HTT BPND ), an index of 5-HTT levels, in the anterior cingulate and prefrontal cortices (ACC and PFC) of healthy individuals during the fall and winter. Twenty-five per cent of healthy individuals experience seasonal mood changes that affect functioning. 5-HTT BPND has been found to be higher across multiple brain regions in the fall and winter relative to spring and summer, and elevated 5-HTT BPND may lead to extracellular serotonin loss and low mood. We hypothesized that, during the fall and winter, light therapy would reduce 5-HTT BPND in the ACC and PFC, which sample brain regions involved in mood regulation. Method: In a single-blind, placebo-controlled, counterbalanced, crossover design, [(11) C]DASB positron emission tomography was used measure 5-HTT BPND following light therapy and placebo conditions during fall and winter. Results: In winter, light therapy significantly decreased 5-HTT BPND by 12% in the ACC relative to placebo (F1,9 = 18.04, P = 0.002). In the fall, no significant change in 5-HTT BPND was found in any region across conditions. Conclusion: These results identify, for the first time, a central biomarker associated with the intervention of light therapy in humans which may be applied to further develop this treatment for prevention of seasonal depression. |
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| MeSH term(s) | Adult ; Biomarkers/metabolism ; Cross-Over Studies ; Female ; Gyrus Cinguli/metabolism ; Humans ; Male ; Phototherapy/instrumentation ; Phototherapy/methods ; Positron-Emission Tomography/methods ; Prefrontal Cortex/metabolism ; Protein Binding ; Seasons ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Single-Blind Method ; Young Adult | |||||
| Chemical Substances | Biomarkers ; SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins | |||||
| Language | English | |||||
| Publishing date | 2015-04-17 | |||||
| Publishing country | United States | |||||
| Document type | Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 103-x | |||||
| ISSN | 1600-0447 ; 0001-690X | |||||
| ISSN (online) | 1600-0447 | |||||
| ISSN | 0001-690X | |||||
| DOI | 10.1111/acps.12424 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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