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  1. Article ; Online: Antiviral and Antibacterial Nanostructured Surfaces with Excellent Mechanical Properties for Hospital Applications.

    Hasan, Jafar / Xu, Yanan / Yarlagadda, Tejasri / Schuetz, Michael / Spann, Kirsten / Yarlagadda, Prasad Kdv

    ACS biomaterials science & engineering

    2020  Volume 6, Issue 6, Page(s) 3608–3618

    Abstract: ... on aluminum (Al) 6063 alloy surfaces. The surfaces were etched for 0.5, 1, and 3 h. The surfaces were ... used a wet etching technique to fabricate 23 nm wide nanostructures randomly aligned as ridges ... With the rise of bacterial and viral infections including the recent outbreak of coronavirus ...

    Abstract With the rise of bacterial and viral infections including the recent outbreak of coronavirus, the requirement for novel antimicrobial strategies is also rising with urgency. To solve this problem, we have used a wet etching technique to fabricate 23 nm wide nanostructures randomly aligned as ridges on aluminum (Al) 6063 alloy surfaces. The surfaces were etched for 0.5, 1, and 3 h. The surfaces were characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, contact angle goniometry, nanoindentation and atomic force microscopy. Strains of the Gram negative bacteria
    MeSH term(s) Alloys/chemistry ; Aluminum/chemistry ; Aluminum/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Hospitals ; Hydrophobic and Hydrophilic Interactions ; Mechanical Phenomena ; Nanostructures/chemistry ; Surface Properties
    Chemical Substances Alloys ; Anti-Bacterial Agents ; Antiviral Agents ; Aluminum (CPD4NFA903)
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.0c00348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antiviral and Antibacterial Nanostructured Surfaces with Excellent Mechanical Properties for Hospital Applications

    Hasan, J. / Xu, Y. A. / Yarlagadda, T. / Schuetz, M. / Spann, K. / Yarlagadda, Pkdv

    Acs Biomaterials Science & Engineering

    Abstract: ... and antiviral property of the nanostructured surface with excellent nanomechanical properties ... for antiviral activity on nanostructured surfaces It was found that the etched Al surfaces were hydrophilic and ... surfaces The nanostructured surfaces exhibited excellent durability as the surfaces sustained 1000 cycles ...

    Abstract With the rise of bacterial and viral infections including the recent outbreak of coronavirus, the requirement for novel antimicrobial strategies is also rising with urgency To solve this problem, we have used a wet etching technique to fabricate 23 nm wide nanostructures randomly aligned as ridges on aluminum (Al) 6063 alloy surfaces The surfaces were etched for 0 5, 1, and 3 h The surfaces were characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, contact angle goniometry, nanoindentation and atomic force microscopy Strains of the Gram negative bacteria Pseudomonas aeruginosa and the Gram positive bacteria Staphylococcus aureus were used to evaluate the bacterial attachment behavior For the first time, common respiratory viruses, respiratory syncytial virus (RSV) and rhinovirus (RV), were investigated for antiviral activity on nanostructured surfaces It was found that the etched Al surfaces were hydrophilic and the nanoscale roughness enhanced with the etching time with R-rms ranging from 69 9 to 995 nm Both bacterial cells of P aeruginosa and S aureus were physically deformed and were nonviable upon attachment after 3 h on the etched Al 6063 surface This nanoscale surface topography inactivated 92 and 87% of the attached P aeruginosa and S aureus cells, respectively The recovery of infectious RSV was also reduced significantly within 2 h of exposure to the nanostructured surfaces compared to the smooth Al control surfaces There was a 3-4 log(10) reduction in the viability counts of rhinovirus after 24 h on the nanostructured surfaces The nanostructured surfaces exhibited excellent durability as the surfaces sustained 1000 cycles of 2000 mu N load without any damage This is the first report that has shown the combined antibacterial and antiviral property of the nanostructured surface with excellent nanomechanical properties that could be potentially significant for use in hospital environments to stop the spread of infections arising from physical surfaces
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #621848
    Database COVID19

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