Article ; Online: Peripartal anti-SARS-CoV-2-IgA/IgG in asymptomatic pregnant women during regional SARS-CoV-2-outbreak.
2021 Volume 49, Issue 6, Page(s) 709–716
Abstract: ... hospital we focused on anti-SARS-CoV-2-specific IgG and IgA antibody responses. Hundred and fifty one women ... 2-antibody levels in the peripartum period of asymptomatic women. As the positive anti-SARS-CoV-2 ... Results: A total of 89% showed negative results for anti-SARS-CoV-2-IgA antibodies, whereas 3% were ...
| Abstract | Objectives: The Severe Acute Respiratory Distress Corona Virus 2 (SARS-CoV-2) pandemic poses special challenges for the society and especially the medical staff. Even if a rather mild course is assumed among pregnant women the measures to prevent transmission of the infection are of outstanding importance. Methods: To screen asymptomatic pregnant women during admission to our university maternal hospital we focused on anti-SARS-CoV-2-specific IgG and IgA antibody responses. Hundred and fifty one women admitted to the hospital for childbirth or caesarean delivery were included. In case of suspicious anti-SARS-CoV-2-antibody levels an RT-PCR was performed to confirm an ongoing infection with SARS-CoV-2. Results: A total of 89% showed negative results for anti-SARS-CoV-2-IgA antibodies, whereas 3% were borderline and 7% positive (both labeled as suspicious). In only one patient with suspicious serology we detected SARS-CoV-2-RNA in the following RT-PCR. 2% presented anti-SARS-CoV-2-IgG antibodies, all being positive for anti-SARS-CoV-2-IgA. The observed positive rate of our study collective of 10.6% seemed much higher than the expected one (1.3%) based on the reports of the Robert Koch Institute and the specifications given by the test's manufacturer. The expected positive predictive value (PPV) was 4.3-6.7 times higher than the observed one. Conclusions: To our knowledge this is the first report of anti-SARS-CoV-2-antibody levels in the peripartum period of asymptomatic women. As the positive anti-SARS-CoV-2 serology poorly correlated with the confirmatory RT-PCR and the fact that mainly the detection of the virus by PCR correlates with the patient's infectiousness we suggest to rather perform a SARS-CoV-2-PCR-based admission screening in perinatal centers to prevent the spread of the disease. |
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| MeSH term(s) | Adolescent ; Adult ; Asymptomatic Infections ; COVID-19/diagnosis ; COVID-19/immunology ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Middle Aged ; Predictive Value of Tests ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/immunology ; Retrospective Studies ; SARS-CoV-2/immunology ; Young Adult | |||||
| Chemical Substances | Immunoglobulin A ; Immunoglobulin G | |||||
| Language | English | |||||
| Publishing date | 2021-02-24 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 123512-6 | |||||
| ISSN | 1619-3997 ; 0300-5577 ; 0936-174X | |||||
| ISSN (online) | 1619-3997 | |||||
| ISSN | 0300-5577 ; 0936-174X | |||||
| DOI | 10.1515/jpm-2021-0001 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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