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  1. Article ; Online: Clinical Characteristics and Early Interventional Responses in Patients with Severe COVID-19 Pneumonia.

    He, Susu / Fang, Lina / Xia, Lingzhen / Lin, Shuangxiang / Ye, Junhui / Luo, Dinghai

    Computational and mathematical methods in medicine

    2021  Volume 2021, Page(s) 6676987

    Abstract: ... therapy to improve the prognosis of COVID-19-induced pneumonia patients. ... with severe COVID-19 pneumonia due to uncontrolled inflammatory reaction, for which we found ... that early intervention of combined treatment with methylprednisolone and human immunoglobulin is a highly effective ...

    Abstract Progressive acute respiratory distress syndrome (ARDS) is the most lethal cause in patients with severe COVID-19 pneumonia due to uncontrolled inflammatory reaction, for which we found that early intervention of combined treatment with methylprednisolone and human immunoglobulin is a highly effective therapy to improve the prognosis of COVID-19-induced pneumonia patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; China/epidemiology ; Computational Biology ; Early Diagnosis ; Female ; Humans ; Immunization, Passive ; Male ; Middle Aged ; Pandemics ; Prognosis ; SARS-CoV-2 ; Severity of Illness Index ; COVID-19 Drug Treatment ; COVID-19 Serotherapy
    Language English
    Publishing date 2021-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252430-7
    ISSN 1748-6718 ; 1748-670X ; 1027-3662
    ISSN (online) 1748-6718
    ISSN 1748-670X ; 1027-3662
    DOI 10.1155/2021/6676987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6373: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clinical Characteristics and Early Interventional Responses in Patients with Severe COVID-19 Pneumonia

    Susu He / Lina Fang / Lingzhen Xia / Shuangxiang Lin / Junhui Ye / Dinghai Luo

    Computational and Mathematical Methods in Medicine, Vol

    2021  Volume 2021

    Abstract: ... 2019 and has claimed millions of lives. Methods. We included 37 severe COVID-19 pneumonia patients ... Coronavirus Disease-2019 (COVID-19) pneumonia, as well as measures to ensure early diagnosis and intervention ... respiratory distress syndrome is the most common cause of death in patients with severe COVID-19 pneumonia ...

    Abstract Progressive acute respiratory distress syndrome (ARDS) is the most lethal cause in patients with severe COVID-19 pneumonia due to uncontrolled inflammatory reaction, for which we found that early intervention of combined treatment with methylprednisolone and human immunoglobulin is a highly effective therapy to improve the prognosis of COVID-19-induced pneumonia patients. Objective. Herein, we have demonstrated the clinical manifestations, laboratory, and radiological characteristics of patients with severe Coronavirus Disease-2019 (COVID-19) pneumonia, as well as measures to ensure early diagnosis and intervention for improving clinical outcomes of COVID-19 patients. Summary Background Data. The COVID-19 is a new infection caused by a severe acute respiratory syndrome- (SARS-) like coronavirus that emerged in China in December 2019 and has claimed millions of lives. Methods. We included 37 severe COVID-19 pneumonia patients who were hospitalized at Taizhou Public Health Medical Center in Zhejiang province from January 17, 2020, to February 18, 2020. Demographic, clinical, and laboratory features; imaging characteristics; treatment history; and clinical outcomes of all patients were collected from electronic medical records. Results. The patients’ mean age was 54 years (interquartile range, 43−64), with a slightly higher male preponderance (57%). The most common clinical features of COVID-19 pneumonia were fever (29 (78%)), dry cough (28 (76%)), dyspnea (9 (24%)), and fatigue (9 (24%)). Serum interleukin (IL)-6 and IL-10 were elevated in 35 (95%) and 19 (51%) patients, respectively. Chest computerized tomography scan revealed bilateral pneumonia in 35 (95%) patients. Early intervention with a combination of methylprednisolone and human immunoglobulin was highly effective in improving the prognosis of these patients. Conclusions. Progressive acute respiratory distress syndrome is the most common cause of death in patients with severe COVID-19 pneumonia owing to an uncontrolled inflammatory response. Early ...
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 610 ; 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Clinical observation and management of COVID-19 patients.

    Li, Taisheng / Lu, Hongzhou / Zhang, Wenhong

    Emerging microbes & infections

    2020  Volume 9, Issue 1, Page(s) 687–690

    Abstract: ... in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care ... 19 patients. For severe or critically ill patients, in addition to the respiratory supportive ... for Shanghai's overall clinical management of the COVID-19 cases. He introduces the team approach to manage COVID ...

    Abstract Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormality of coagulation function and proposes that the early intravenous immunoglobulin and low molecular weight heparin anticoagulation therapy are very important. Professor Hongzhou Lu, a leader in China to try various anti-viral drugs, expresses concern on the quality of the ongoing clinical trials as most trials are small in scale and repetitive in nature, and emphasizes the importance of the quick publication of clinical trial results. Regarding the traditional Chinese medicine, Professor Lu suggests to develop a creative evaluation system because of the complicated chemical compositions. Professor Wenhong Zhang is responsible for Shanghai's overall clinical management of the COVID-19 cases. He introduces the team approach to manage COVID-19 patients. For severe or critically ill patients, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial. The medical decisions and interventions are carefully tailored to the unique characteristics of each patient.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; China ; Clinical Trials as Topic ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Coronavirus Infections/therapy ; Critical Illness ; Disease Progression ; Female ; Glucocorticoids/therapeutic use ; Humans ; Male ; Medicine, Chinese Traditional ; Pandemics ; Patient Care Management ; Patient Care Team ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Thrombophilia/physiopathology ; Thrombophilia/therapy ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Glucocorticoids
    Keywords covid19
    Language English
    Publishing date 2020-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2020.1741327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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