Article ; Online: COVID-19 in persons with haematological cancers.
2020 Volume 34, Issue 6, Page(s) 1637–1645
Abstract: ... persons with haematological cancers have a similar case rate of COVID-19 compared with normal ... specific risk factors for COVID-19 in hospitalised persons with haematological cancers, we suggest ... China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19 ...
| Abstract | Infection with SARS-CoV-2, the cause of coronavirus infectious disease-19 (COVID-19), has caused a pandemic with >850,000 cases worldwide and increasing. Several studies report outcomes of COVID-19 in predominately well persons. There are also some data on COVID-19 in persons with predominately solid cancer but controversy whether these persons have the same outcomes. We conducted a cohort study at two centres in Wuhan, China, of 128 hospitalised subjects with haematological cancers, 13 (10%) of whom developed COVID-19. We also studied 226 health care providers, 16 of whom developed COVID-19 and 11 of whom were hospitalised. Co-variates were compared with the 115 subjects with haematological cancers without COVID-19 and with 11 hospitalised health care providers with COVID-19. There were no significant differences in baseline co-variates between subjects with haematological cancers developing or not developing COVID-19. Case rates for COVID-19 in hospitalised subjects with haematological cancers was 10% (95% Confidence Interval [CI], 6, 17%) compared with 7% (4, 12%; P = 0.322) in health care providers. However, the 13 subjects with haematological cancers had more severe COVID-19 and more deaths compared with hospitalised health care providers with COVID-19. Case fatality rates were 62% (32, 85%) and 0 (0, 32%; P = 0.002). Hospitalised persons with haematological cancers have a similar case rate of COVID-19 compared with normal health care providers but have more severe disease and a higher case fatality rate. Because we were unable to identify specific risk factors for COVID-19 in hospitalised persons with haematological cancers, we suggest increased surveillance and possible protective isolation. |
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| MeSH term(s) | Adult ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/epidemiology ; Humans ; Incidence ; Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Young Adult |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-04-24 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 807030-1 |
| ISSN | 1476-5551 ; 0887-6924 |
| ISSN (online) | 1476-5551 |
| ISSN | 0887-6924 |
| DOI | 10.1038/s41375-020-0836-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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