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  1. Article ; Online: Clinical Symptom Differences Between Mild and Severe COVID-19 Patients in China: A Meta-Analysis.

    He, Xiaobo / Cheng, Xiao / Feng, Xudong / Wan, Hong / Chen, Sihan / Xiong, Maoming

    Frontiers in public health

    2021  Volume 8, Page(s) 561264

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; COVID-19/physiopathology ; China/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Risk Assessment/statistics & numerical data ; SARS-CoV-2/pathogenicity ; Severe Acute Respiratory Syndrome/physiopathology ; Symptom Assessment/statistics & numerical data
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.561264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical Symptom Differences Between Mild and Severe COVID-19 Patients in China

    Xiaobo He / Xiao Cheng / Xudong Feng / Hong Wan / Sihan Chen / Maoming Xiong

    Frontiers in Public Health, Vol

    A Meta-Analysis

    2021  Volume 8

    Abstract: Objective: The prognosis of mild and severe patients has prominent differences during ... the clinical symptoms of the COVID-19 epidemic systematically.Methods:We searched PubMed, Embase, Web of Science, and ... the prevalence of COVID-19, and it will be significant to identify patients' potential risk of progressing ...

    Abstract Objective: The prognosis of mild and severe patients has prominent differences during the prevalence of COVID-19, and it will be significant to identify patients' potential risk of progressing to severe cases according to their first clinical presentations. Therefore, we aim to review the clinical symptoms of the COVID-19 epidemic systematically.Methods:We searched PubMed, Embase, Web of Science, and CNKI (Chinese Database) for studies about the clinical features of COVID-19 in China from March 18 to April 18. Then we used REVMAN to conduct a meta-analysis.Results: After screening, 20 articles including 3,326 COVID-19 confirmed cases were selected from 142 articles we retrieved at the beginning of our research. We divided all the cases into a severe group (including severe and critically severe patients) and a mild group according to the “Diagnosis and Treatment Protocol for Novel Coronavirus Infection-Induced Pneumonia” version 4 (trial). Of all the initial symptoms (including fever, cough, abdominal pain, anorexia, chest tightness, diarrhea, dyspnea, expectoration, fatigue, headache, hemoptysis, myalgia, nausea or vomiting, and pharyngalgia) we studied, we found that cough (odds ratio [OR] = 1.4, 95% confidence interval [CI]: 1.2–1.7; p < 0.001), fever (OR = 1.5, 95% CI: 1.2–1.9; p < 0.001), dyspnea (OR = 6.2, 95% CI: 3.6–10.6; p < 0.001), diarrhea (OR = 2.6, 95% CI: 1.3–4.9; p < 0.001), fatigue (OR = 2.1, 95% CI: 1.3–3.3; p < 0.01), expectoration (OR = 1.7, 95% CI: 1.2–2.6; p < 0.01), myalgia (OR = 1.6, 95% CI: 0.8–3.1; p < 0.001), hemoptysis (OR = 4.0, 95% CI: 1.5–11.3; p < 0.001), abdominal pain (OR = 7.5, 95% CI: 2.4–23.4; p < 0.001), and anorexia (OR = 2.8, 95% CI: 1.5–5.1; p < 0.001) had a different distribution in two groups and were statistically significant (p < 0.05).Conclusion:COVID-19 patients whose initial manifestation is dyspnea, hemoptysis, anorexia, diarrhea, or fatigue, especially abdominal pain should be closely monitored to prevent disease deterioration.
    Keywords COVID-19 ; clinical features ; differences ; risk factor ; meta-analysis ; Public aspects of medicine ; RA1-1270
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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