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  1. Article ; Online: Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.

    Hedenstierna, Göran / Chen, Luni / Hedenstierna, Magnus / Lieberman, Robert / Fine, David H

    Nitric oxide : biology and chemistry

    2020  Volume 103, Page(s) 1–3

    Abstract: ... the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism ... coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion ... of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and ...

    Abstract It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO
    MeSH term(s) Administration, Inhalation ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Female ; Humans ; Male ; Nitric Oxide/administration & dosage ; Nitric Oxide/pharmacology ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; SARS-CoV-2 ; Smokers ; Smoking ; COVID-19 Drug Treatment
    Chemical Substances Protective Agents ; Nitric Oxide (31C4KY9ESH)
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2020.06.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article: Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19

    Hedenstierna, Göran / Chen, Luni / Hedenstierna, Magnus / Lieberman, Robert / Fine, David H

    Nitric Oxide

    Abstract: ... to provide the drug intermittently in short bursts at high concentration dose, which would then provide ... the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism ... coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion ...

    Abstract It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #611235
    Database COVID19

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  3. Article ; Online: Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19.

    Hedenstierna, Göran / Chen, Luni / Hedenstierna, Magnus / Lieberman, Robert / Fine, David H

    2020  

    Abstract: ... to provide the drug intermittently in short bursts at high concentration dose, which would then provide ... the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism ... coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion ...

    Abstract It has long been suggested that NO may inhibit an early stage in viral replication. Furthermore, in vitro tests have shown that NO inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Despite smoking being listed as a risk factor to contract Covid-19, only a low proportion of the smokers suffered from SARS-corona infection in China 2003, and from Covid-19 in China, Europe and the US. We hypothesize, that the intermittent bursts of high NO concentration in cigarette smoke may be a mechanism in protecting against the virus. Mainstream smoke from cigarettes contains NO at peak concentrations of between about 250 ppm and 1350 ppm in each puff as compared to medicinal use of no more than 80 to a maximum of 160 ppm. The diffusion of NO through the cell wall to reach the virus should be significantly more effective at the very high NO concentration in the smoke, according to classic laws of physics. The only oxide of nitrogen in the mainstream smoke is NO, and the NO2 concentration that is inhaled is very low or undetectable, and methemoglobin levels are lower in smokers than non-smokers, reasonably explained by the breaths of air in between the puffs that wash out the NO. Specialized iNO machines can now be developed to provide the drug intermittently in short bursts at high concentration dose, which would then provide both a preventative drug for those at high risk, as well as an effective treatment, without the health hazards associated with smoking.
    Keywords Covid-19 ; Nitric oxide ; Smoking ; Viral suppression ; Medical and Health Sciences ; Medicin och hälsovetenskap ; covid19
    Subject code 616
    Language English
    Publisher Uppsala universitet, Klinisk fysiologi
    Publishing country se
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  4. Article ; Online: Nitric oxide dosed in short bursts at high concentrations may protect against Covid 19

    Hedenstierna, Göran / Chen, Luni / Hedenstierna, Magnus / Lieberman, Robert / Fine, David H.

    Nitric Oxide

    2020  Volume 103, Page(s) 1–3

    Keywords Clinical Biochemistry ; Biochemistry ; Cancer Research ; Physiology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1362794-6
    ISSN 1089-8611 ; 1089-8603
    ISSN (online) 1089-8611
    ISSN 1089-8603
    DOI 10.1016/j.niox.2020.06.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4677: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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