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  1. Article ; Online: Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients.

    Hellmuth, Joanna / Barnett, T Allen / Asken, Breton M / Kelly, J Daniel / Torres, Leonel / Stephens, Melanie L / Greenhouse, Bryan / Martin, Jeffrey N / Chow, Felicia C / Deeks, Steven G / Greene, Meredith / Miller, Bruce L / Annan, Wesley / Henrich, Timothy J / Peluso, Michael J

    Journal of neurovirology

    2021  Volume 27, Issue 1, Page(s) 191–195

    Abstract: ... in patients with milder COVID-19. We present two cases of non-hospitalized patients recovering from COVID-19 ... individuals enrolled, 14 were non-hospitalized patients reporting persistent cognitive issues. These 14 ... for at least a median of 98 days (interquartile range: 71-120 following acute COVID-19 symptoms); no ...

    Abstract As cases of coronavirus disease 2019 (COVID-19) mount worldwide, attention is needed on potential long-term neurologic impacts for the majority of patients who experience mild to moderate illness managed as outpatients. To date, there has not been discussion of persistent neurocognitive deficits in patients with milder COVID-19. We present two cases of non-hospitalized patients recovering from COVID-19 with persistent neurocognitive symptoms. Commonly used cognitive screens were normal, while more detailed testing revealed working memory and executive functioning deficits. An observational cohort study of individuals recovering from COVID-19 (14 or more days following symptom onset) identified that among the first 100 individuals enrolled, 14 were non-hospitalized patients reporting persistent cognitive issues. These 14 participants had a median age of 39 years (interquartile range: 35-56), and cognitive symptoms were present for at least a median of 98 days (interquartile range: 71-120 following acute COVID-19 symptoms); no participants with follow-up evaluation reported symptom resolution. We discuss potential mechanisms to be explored in future studies, including direct viral effects, indirect consequences of immune activation, and immune dysregulation causing auto-antibody production.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/immunology ; COVID-19/physiopathology ; COVID-19/virology ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/immunology ; Cognitive Dysfunction/physiopathology ; Cognitive Dysfunction/virology ; Executive Function/physiology ; Female ; Humans ; Memory, Short-Term/physiology ; Middle Aged ; Neuropsychological Tests ; Outpatients ; SARS-CoV-2/pathogenicity ; Time Factors
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
    DOI 10.1007/s13365-021-00954-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4426: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study.

    Seeßle, Jessica / Waterboer, Tim / Hippchen, Theresa / Simon, Julia / Kirchner, Marietta / Lim, Adeline / Müller, Barbara / Merle, Uta

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 74, Issue 7, Page(s) 1191–1198

    Abstract: ... were ≥1:160 in 43.6% of patients at 12 months post-COVID-19 symptom onset, and neurocognitive symptom ... of symptoms we analyzed a cohort of patients with COVID-19 prospectively.: Methods: Patients were included ... can persist ≥1 year after COVID-19 symptom onset and reduce life quality significantly. Several neurocognitive symptoms ...

    Abstract Background: Long COVID is defined as the persistence of symptoms beyond 3 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To better understand the long-term course and etiology of symptoms we analyzed a cohort of patients with COVID-19 prospectively.
    Methods: Patients were included at 5 months after acute COVID-19 in this prospective, noninterventional, follow-up study. Patients followed until 12 months after COVID-19 symptom onset (n = 96; 32.3% hospitalized, 55.2% females) were included in this analysis of symptoms, quality of life (based on an SF-12 survey), laboratory parameters including antinuclear antibodies (ANAs), and SARS-CoV-2 antibody levels.
    Results: At month 12, only 22.9% of patients were completely free of symptoms and the most frequent symptoms were reduced exercise capacity (56.3%), fatigue (53.1%), dyspnea (37.5%), and problems with concentration (39.6%), finding words (32.3%), and sleeping (26.0%). Females showed significantly more neurocognitive symptoms than males. ANA titers were ≥1:160 in 43.6% of patients at 12 months post-COVID-19 symptom onset, and neurocognitive symptom frequency was significantly higher in the group with an ANA titer ≥1:160 versus <1:160. Compared with patients without symptoms, patients with ≥1 long-COVID symptom at 12 months did not differ significantly with respect to their SARS-CoV-2 antibody levels but had a significantly reduced physical and mental life quality compared with patients without symptoms.
    Conclusions: Neurocognitive long-COVID symptoms can persist ≥1 year after COVID-19 symptom onset and reduce life quality significantly. Several neurocognitive symptoms were associated with ANA titer elevations. This may indicate autoimmunity as a cofactor in etiology of long COVID.
    MeSH term(s) Adult ; Antibodies, Viral ; COVID-19/complications ; Female ; Follow-Up Studies ; Humans ; Male ; Prospective Studies ; Quality of Life ; SARS-CoV-2
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-01-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1505: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 480: Show issues

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  3. Article ; Online: Neurocognitive Profiles in Patients With Persisting Cognitive Symptoms Associated With COVID-19.

    Krishnan, Kamini / Miller, Ashley K / Reiter, Katherine / Bonner-Jackson, Aaron

    Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

    2022  Volume 37, Issue 4, Page(s) 729–737

    Abstract: ... a significant role in subjective cognitive complaints in patients with persisting complaints post COVID-19 ... cognitive complaints about 5.5 months after COVID-19 infection.: Methods: Patients ... to COVID-19 infection. At the time of testing, 35%-40% endorsed moderate to severe mood symptoms and 85 ...

    Abstract Objective: A subset of individuals with coronavirus disease 2019 (COVID-19) appears to develop persisting cognitive and medical symptoms. Research in the acute stages of illness, generally utilizing cognitive screening measures or case reports, suggests presence of deficits in attention and executive function. This observational study investigated cognitive functioning among individuals with persistent cognitive complaints about 5.5 months after COVID-19 infection.
    Methods: Patients with polymerase chain reaction confirmed COVID-19 and persistent cognitive complaints underwent comprehensive in-person neuropsychological evaluations. Patients with prior neurological disorders were excluded. When diagnosed, 40% required hospitalization, 15% were in an intensive care unit, 10% needed mechanical ventilation, and 10% experienced delirium.
    Results: This sample was predominately women (90%), White non-Hispanic (70%), with average education of 15 years. Mild cognitive deficits were seen on tests involving attention and processing speed or executive function. Seventy percent of patients were diagnosed with a mood disorder prior to COVID-19 infection. At the time of testing, 35%-40% endorsed moderate to severe mood symptoms and 85% noted significant fatigue as measured by the Fatigue Severity Scale.
    Conclusions: The pattern of cognitive deficits, although mild, is consistent with prior research at the acute stage of the illness. These findings suggest that psychological factors and other persisting symptoms (e.g., sleep, fatigue) may play a significant role in subjective cognitive complaints in patients with persisting complaints post COVID-19 who did not require intensive treatment. These patients would likely benefit from resources to manage persisting or new mood symptoms and compensatory strategies for the cognitive inefficiencies they experience.
    MeSH term(s) COVID-19/complications ; Cognition ; Cognition Disorders/complications ; Cognition Disorders/etiology ; Fatigue ; Female ; Humans ; Neuropsychological Tests
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 632972-x
    ISSN 1873-5843 ; 0887-6177
    ISSN (online) 1873-5843
    ISSN 0887-6177
    DOI 10.1093/arclin/acac004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2993: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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