Article ; Online: Factors associated with viral clearance periods from patients with COVID-19: A retrospective observational cohort study.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2021 Volume 27, Issue 6, Page(s) 864–868
Abstract: ... taken for viral clearance in patients with COVID-19 to determine the optimal isolation period ... of the isolation periods based on age could be considered. A uniform viral clearance period for older patients ... Methods: This two-center retrospective observational cohort study was conducted between March 1 and June ...
| Abstract | Introduction: Knowledge is limited on the virologic course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, particularly the time taken for viral clearance and the optimal time to discontinue isolation. This study aims to identify the clinical and demographic factors influencing the time taken for viral clearance in patients with COVID-19 to determine the optimal isolation period. Methods: This two-center retrospective observational cohort study was conducted between March 1 and June 31, 2020. Patients with COVID-19, which was confirmed by real-time reverse transcription polymerase chain reaction, were included. Data were extracted from medical records. The positive duration, which was defined as the period from the day of symptom onset to the negative conversion day, was assessed using a generalized linear model. Results: We included 63 patients. The mean positive duration was 20 days. The positive duration was significantly shorter for patients younger than 30 years of age and those between 30 and 60 years of age than for patients older than 60 years of age. We observed a more scattered distribution of the positive duration in older patients than in younger patients. Conclusions: Younger patients who recovered from COVID-19 took less time to clear SARS-CoV-2 than older patients; thus, a classification of the isolation periods based on age could be considered. A uniform viral clearance period for older patients may be difficult to determine because of biases such as underlying medical conditions. Further surveillance measures are recommended to determine the viral clearance time and the optimal isolation period. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Adult ; Aged ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Nucleic Acid Testing ; Female ; Humans ; Hypertension ; Male ; Middle Aged ; Patient Isolation ; Real-Time Polymerase Chain Reaction ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2 ; Viral Load | |||||
| Chemical Substances | Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors | |||||
| Language | English | |||||
| Publishing date | 2021-02-18 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Multicenter Study ; Observational Study | |||||
| ZDB-ID | 1355399-9 | |||||
| ISSN | 1437-7780 ; 1341-321X | |||||
| ISSN (online) | 1437-7780 | |||||
| ISSN | 1341-321X | |||||
| DOI | 10.1016/j.jiac.2021.02.015 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5236: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.