LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 2 of total 2

Search options

  1. Article: Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment.

    Hitchcock, C L / Bland, K I / Laney, R G / Franzini, D / Harris, B / Copeland, E M

    Annals of surgery

    1988  Volume 207, Issue 2, Page(s) 201–207

    Abstract: Over 400 cases of neuroendocrine (Merkel cell) carcinoma of the skin (NCS) have been reported ... for the treatment of squamous cell carcinoma of the skin. ... This tumor continues to pose problems in diagnosis and effective treatment for physicians unfamiliar ...

    Abstract Over 400 cases of neuroendocrine (Merkel cell) carcinoma of the skin (NCS) have been reported. This tumor continues to pose problems in diagnosis and effective treatment for physicians unfamiliar with its biological characteristics. Reported here are five additional cases of NCS and the literature for this rare neoplasm is comprehensively reviewed. An early and accurate diagnosis is made possible by combining clinical presentation with results of histologic study, immunoperoxidase staining for neuron-specific enolase (NSE), epithelial membrane antigen (EMA), cytokeratins, and electron microscopy. NCS is an aggressive tumor. Depending on the length of follow-up, up to 40% of tumors locally recur, 55% develop regional nodal metastases, and 36% undergo distant metastasis. Survival is sex, but not age, dependent, with an overall 2-year survival rate of 72% (males 58% vs. females 79%). No standard procedure for initial and/or follow-up treatment for NCS exists. The authors recommend that NCS be treated, whenever possible, using the same rationale as applied for the treatment of squamous cell carcinoma of the skin.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/pathology ; Adenocarcinoma/therapy ; Aged ; Apudoma/diagnosis ; Apudoma/pathology ; Apudoma/therapy ; Combined Modality Therapy ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Soft Tissue Neoplasms/diagnosis ; Soft Tissue Neoplasms/pathology ; Soft Tissue Neoplasms/therapy
    Language English
    Publishing date 1988-02
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-198802000-00015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.35/1: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Primary neuroendocrine carcinoma ("Merkel cell tumor") of the eyelid: a report of two cases.

    Di Maria, Alessandra / Carnevali, Luciano / Redaelli, Carla / Trimarchi, Fernando

    Orbit (Amsterdam, Netherlands)

    2000  Volume 19, Issue 3, Page(s) 171–177

    Abstract: ... identified the lesion as a neuroendocrine carcinoma, consistent with Merkel cell tumor. The natural history ... different therapeutic approaches. CONCLUSION. Merkel cell carcinoma of the eyelid is a tumor ... of this report is to describe two new cases and to discuss briefly the problems of diagnosis and treatment ...

    Abstract BACKGROUND. Merkel cell tumor is an uncommon, aggressive neoplasm of the skin, now regarded as a neuroendocrine carcinoma. Eyelids are among the sites where it can develop, often mimicking a benign process. The purpose of this report is to describe two new cases and to discuss briefly the problems of diagnosis and treatment. METHODS. Two patients with Merkel cell tumor of the eyelids are described. In both cases, the original clinical diagnosis was chalazion. Progressive growth of the lesion identified it as a tumor some 2-7 months after it was first noticed. The patients were treated by surgical excision of the tumor tissue, and only one by a course of local radiotherapy. The visual acuity was measured with Snellen fractions. The dose of local radiotherapy is given in cGy. RESULTS. Histopathological and immunohistochemical studies identified the lesion as a neuroendocrine carcinoma, consistent with Merkel cell tumor. The natural history was marked by aggressive behavior in one case, and by a delayed recurrence in the other, requiring different therapeutic approaches. CONCLUSION. Merkel cell carcinoma of the eyelid is a tumor that ophthalmogists should be aware of, as early diagnosis is a prerequisite for successful treatment. Rapid recurrence of any chalazion in a middle-aged or elderly patient should therefore prompt its histological examination to exclude the possibility of a malignant tumor.
    Language English
    Publishing date 2000-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 603157-2
    ISSN 1744-5108 ; 0167-6830
    ISSN (online) 1744-5108
    ISSN 0167-6830
    DOI 10.1076/orbi.19.3.171.2664
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1735: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top