Article: Susceptibility of mononuclear phagocytes to influenza A virus infection and possible role in the antiviral response.
1997 Volume 61, Issue 4, Page(s) 408–414
Abstract: ... macrophages represent a primary target for an influenza A virus infection. Thus, the mononuclear phagocyte ... control values thereafter. After influenza A virus infection, only the mononuclear cell attracting CC-chemokines ... the preferential influx of mononuclear leukocytes into virus-infected tissue. Our data show that monocytes and ...
| Abstract | Among leukocytes, only monocytes and macrophages were found to be highly susceptible to an infection by influenza A virus. After infection, de novo viral protein synthesis was initiated but then interrupted after 4-6 h. Most macrophages died by apoptosis within 25-30 h. Before cell death, however, macrophages responded to influenza A virus with a high cytokine gene transcription and subsequent release of tumor necrosis factor alpha (TNF-alpha), interleukin-1 (IL-1), IL-6, interferon (IFN)-alpha/beta, and CC-chemokines. The basic mechanisms of virus-induced cytokine expression are still unknown and appear to involve transcription factors such as nuclear factor-kappaB and AP-1 which, however, were only activated for 2 h and declined below control values thereafter. After influenza A virus infection, only the mononuclear cell attracting CC-chemokines macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, and RANTES were produced while the prototype neutrophil CXC-chemoattractants IL-8 and GRO-alpha were entirely suppressed. This selective induction of CC-chemokines may explain the preferential influx of mononuclear leukocytes into virus-infected tissue. Our data show that monocytes and macrophages represent a primary target for an influenza A virus infection. Thus, the mononuclear phagocyte response leads to a rapid proinflammatory reaction and an enhanced immigration of mononuclear leukocytes, which may condition the infected host for the subsequent virus antigen-specific defense. |
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| MeSH term(s) | Apoptosis/physiology ; Cells, Cultured ; Chemotaxis, Leukocyte ; Cytokines/biosynthesis ; Cytokines/metabolism ; Disease Susceptibility ; Fluorescent Antibody Technique ; Humans ; Influenza A virus ; Influenza, Human/immunology ; Influenza, Human/metabolism ; Influenza, Human/pathology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Phagocytes/immunology ; Phagocytes/metabolism ; Phagocytes/virology ; Up-Regulation/drug effects ; Viral Proteins/biosynthesis | |||||
| Chemical Substances | Cytokines ; Viral Proteins | |||||
| Language | English | |||||
| Publishing date | 1997-04 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 605722-6 | |||||
| ISSN | 1938-3673 ; 0741-5400 | |||||
| ISSN (online) | 1938-3673 | |||||
| ISSN | 0741-5400 | |||||
| DOI | 10.1002/jlb.61.4.408 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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