Article: Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology
2006 Volume 288, Issue 7, Page(s) 676–680
Abstract: X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD ... specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene ... regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD. ...
| Abstract | X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is inherited through mutations in EMD, which encodes a nuclear membrane protein named emerin. Emerin is expressed in most cells, but EDMD strikes specific tissues. This review summarizes growing evidence that emerin has roles in both tissue-specific gene regulation and the mechanical integrity of the nucleus and discusses how these roles might impact EDMD. |
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| MeSH term(s) | Animals ; Cell Nucleus/chemistry ; Cell Nucleus/metabolism ; Cell Nucleus/physiology ; Humans ; Membrane Proteins/physiology ; Muscular Dystrophy, Emery-Dreifuss/genetics ; Muscular Dystrophy, Emery-Dreifuss/metabolism ; Muscular Dystrophy, Emery-Dreifuss/pathology ; Muscular Dystrophy, Emery-Dreifuss/physiopathology ; Nuclear Proteins/physiology ; Organ Specificity/genetics | |||||
| Chemical Substances | Membrane Proteins ; Nuclear Proteins ; emerin | |||||
| Language | English | |||||
| Publishing date | 2006-07 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 2103089-3 | |||||
| ISSN | 1552-4884 ; 0003-276X | |||||
| ISSN | 1552-4884 ; 0003-276X | |||||
| DOI | 10.1002/ar.a.20334 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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