Article ; Online: Upregulation of insulin-like growth factor binding protein 3 in astrocytes of transgenic mice that express Borna disease virus phosphoprotein.
2011 Volume 85, Issue 9, Page(s) 4567–4571
Abstract: ... that expression of insulin-like growth factor binding protein 3 mRNA increases not only in P-expressing ... In a previous study, we demonstrated that transgenic mice that express Borna disease virus (BDV ... we demonstrated that insulin-like growth factor signaling is disturbed in the P-Tg cerebellum, a factor ...
| Abstract | In a previous study, we demonstrated that transgenic mice that express Borna disease virus (BDV) phosphoprotein (P) in astrocytes show striking neurobehavioral abnormalities resembling those in BDV-infected animals. To understand the molecular disturbances induced by the expression of P in astrocytes, we performed microarray analysis with cultured astroglial cells transiently expressing P. We showed that expression of insulin-like growth factor binding protein 3 mRNA increases not only in P-expressing cultured cells but also in astrocytes from the cerebella of P transgenic mice (P-Tg). Furthermore, we demonstrated that insulin-like growth factor signaling is disturbed in the P-Tg cerebellum, a factor that might be involved in the increased vulnerability of Purkinje cell neurons in the brain. |
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| MeSH term(s) | Animals ; Astrocytes/virology ; Borna disease virus/pathogenicity ; Cells, Cultured ; Gene Expression Profiling ; Insulin-Like Growth Factor Binding Protein 3/biosynthesis ; Mice ; Mice, Transgenic ; Microarray Analysis ; Phosphoproteins/metabolism ; Up-Regulation ; Viral Structural Proteins/metabolism | |||||
| Chemical Substances | Insulin-Like Growth Factor Binding Protein 3 ; P protein, Borna disease virus ; Phosphoproteins ; Viral Structural Proteins | |||||
| Language | English | |||||
| Publishing date | 2011-02-16 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/JVI.01817-10 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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