Article ; Online: Disorders of calcium and magnesium balance: a physiology-based approach.
Pediatric nephrology (Berlin, Germany)
2012 Volume 28, Issue 8, Page(s) 1195–1206
Abstract: Disorders of calcium and magnesium balance are physiologically interesting and clinically ... a physiology-based approach to understanding hypocalcemia, hypercalcemia and hypomagnesemia. Calcium and ... of this review is to illustrate the clinical disorders of calcium and magnesium balance from the perspective ...
| Abstract | Disorders of calcium and magnesium balance are physiologically interesting and clinically challenging. In this review, we attempt to bridge the gap between physiology and practice by providing a physiology-based approach to understanding hypocalcemia, hypercalcemia and hypomagnesemia. Calcium and, to a lesser extent, magnesium balance is achieved through a complex interplay between the parathyroid gland, bone, the intestine and the kidney. Our understanding of the molecular physiology of calcium and magnesium balance has grown considerably following the discovery of the calcium-sensing receptor (CaSR) and the main intestinal and renal transporters for calcium and magnesium, namely, the transient receptor potential channels TRPV5, TRPV6 and TRPM6. The regulation of parathyroid hormone (PTH) secretion by CaSR and the subsequent effects of PTH and vitamin D on TRPV5 constitute an increasingly characterized regulatory loop. In contrast, no truly magnesiotropic hormones have been identified, although the recently established interactions between the epidermal growth factor and TRPM6 suggest a possible candidate. Overall, the aim of this review is to illustrate the clinical disorders of calcium and magnesium balance from the perspective of their integrated physiology. |
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| MeSH term(s) | Animals ; Calcium/metabolism ; Calcium Metabolism Disorders/metabolism ; Calcium Metabolism Disorders/physiopathology ; Homeostasis ; Humans ; Hypercalcemia/metabolism ; Hypercalcemia/physiopathology ; Hypocalcemia/metabolism ; Hypocalcemia/physiopathology ; Magnesium/metabolism ; Magnesium Deficiency/metabolism ; Magnesium Deficiency/physiopathology | |||||
| Chemical Substances | Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP) | |||||
| Language | English | |||||
| Publishing date | 2012-11-10 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 631932-4 | |||||
| ISSN | 1432-198X ; 0931-041X | |||||
| ISSN (online) | 1432-198X | |||||
| ISSN | 0931-041X | |||||
| DOI | 10.1007/s00467-012-2350-2 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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