Article ; Online: Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander?
2015 Volume 6, Issue 36, Page(s) 38446–38457
Abstract: Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids has been reported ... to be essential for their anti-inflammatory actions. At the same time, GILZ is actively downregulated ... in the recent past showed elevated GILZ expression in the late stage of an inflammation. Still, the manuscripts ...
| Abstract | Induction of glucocorticoid-induced leucine zipper (GILZ) by glucocorticoids has been reported to be essential for their anti-inflammatory actions. At the same time, GILZ is actively downregulated under inflammatory conditions, resulting in an enhanced pro-inflammatory response. Two papers published in the recent past showed elevated GILZ expression in the late stage of an inflammation. Still, the manuscripts suggest seemingly contradictory roles of endogenous GILZ: one of them suggested compensatory actions by elevated corticosterone levels in GILZ knockout mice, while our own manuscript showed a distinct phenotype upon GILZ knockout in vivo. Herein, we discuss the role of GILZ in inflammation with a special focus on the influence of endogenous GILZ on macrophage responses and suggest a cell-type specific action of GILZ as an explanation for the conflicting results as presented in recent reports. |
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| MeSH term(s) | Animals ; Disease Models, Animal ; Glucocorticoids/immunology ; Glucocorticoids/pharmacology ; Humans ; Inflammation/immunology ; Leucine Zippers/immunology ; Lipopolysaccharides/immunology ; Lipopolysaccharides/pharmacology ; Macrophages/immunology ; Mice ; Mice, Knockout ; Transcription Factors/immunology |
| Chemical Substances | Dsip1 protein, mouse ; Glucocorticoids ; Lipopolysaccharides ; TSC22D3 protein, human ; Transcription Factors |
| Language | English |
| Publishing date | 2015-11-17 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2560162-3 |
| ISSN | 1949-2553 ; 1949-2553 |
| ISSN (online) | 1949-2553 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.6197 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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