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  1. Article: Health-related quality of life in systemic sclerosis: a systematic review.

    Hudson, Marie / Thombs, Brett D / Steele, Russell / Panopalis, Pantelis / Newton, Evan / Baron, Murray

    Arthritis and rheumatism

    2009  Volume 61, Issue 8, Page(s) 1112–1120

    Abstract: Objective: A number of studies (all n <200) have assessed health-related quality of life (HRQOL ... in patients with systemic sclerosis (SSc), but no systematic review of the effect of SSc on HRQOL has been ... 127 SSc patients were included in the systematic review. HRQOL was impaired in patients with SSc ...

    Abstract Objective: A number of studies (all n <200) have assessed health-related quality of life (HRQOL) in patients with systemic sclerosis (SSc), but no systematic review of the effect of SSc on HRQOL has been done. The objective of this study was to systematically review the literature on HRQOL in SSc measured using the Medical Outcomes Trust Short Form 36 (SF-36).
    Methods: A comprehensive search was conducted in August 2007 using Medline, CINAHL, and EMBase to identify original research studies reporting SF-36 scores of SSc patients. Selected studies were reviewed and characteristics of the study samples and SF-36 data were extracted. Bayesian meta-analysis and meta-regression were performed to obtain pooled estimates of SF-36 physical component summary (PCS) and mental component summary (MCS) scores for all patients as well as by limited and diffuse disease status.
    Results: Twelve data sets with a total of 1,127 SSc patients were included in the systematic review. HRQOL was impaired in patients with SSc, with pooled SF-36 PCS scores being more than 1 SD below the general population (38.3; 95% credible interval [95% CI] 35.2, 41.5) and pooled SF-36 MCS scores being approximately 0.5 SDs below the general population (46.6; 95% CI 44.2, 49.1). SF-36 PCS scores were 3.5 points (95% CI -1.0, 8.0) lower in patients with diffuse compared with limited disease.
    Conclusion: This study provides robust evidence of the presence and magnitude of impairment in HRQOL in patients with SSc. Although the impairment appears greater in physical health, mental health impairment is also reported.
    MeSH term(s) Activities of Daily Living ; Databases, Bibliographic ; Health Status ; Humans ; Mental Health ; Meta-Analysis as Topic ; Quality of Life ; Scleroderma, Systemic/physiopathology ; Scleroderma, Systemic/psychology ; Severity of Illness Index ; Surveys and Questionnaires
    Language English
    Publishing date 2009-08-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 127294-9
    ISSN 1529-0131 ; 0004-3591 ; 2326-5191
    ISSN (online) 1529-0131
    ISSN 0004-3591 ; 2326-5191
    DOI 10.1002/art.24676
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    Zs.A 24: Show issues Location:
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  2. Article ; Online: Health-related quality of life in systemic sclerosis before and after autologous haematopoietic stem cell transplant-a systematic review.

    Puyade, Mathieu / Maltez, Nancy / Lansiaux, Pauline / Pugnet, Grégory / Roblot, Pascal / Colmegna, Ines / Hudson, Marie / Farge, Dominique

    Rheumatology (Oxford, England)

    2019  Volume 59, Issue 4, Page(s) 779–789

    Abstract: ... to identify, appraise and synthesize the evidence on health-related quality of life (HRQoL) before and after ... 249 patients) and the European Quality of Life 5-Dimensions questionnaire (EQ-5D; 138 patients ... AHSCT for SSc.: Methods: We performed a systematic review of the literature, following the Preferred ...

    Abstract Objectives: In severe rapidly progressive SSc, autologous haematopoietic stem cell transplantation (AHSCT) allows significant improvements in overall and event-free survival. We undertook this study to identify, appraise and synthesize the evidence on health-related quality of life (HRQoL) before and after AHSCT for SSc.
    Methods: We performed a systematic review of the literature, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed and ScienceDirect from database inception to 1 February 2019. All articles with original HRQoL data were selected.
    Results: The search identified 1080 articles, of which 8 were selected: 3 unblinded randomized controlled trials [American Scleroderma Stem Cell versus Immune Suppression Trial (ASSIST), Autologous Stem Cell Transplantation International Scleroderma, Scleroderma: Cyclophosphamide or Transplantation), 3 uncontrolled phase I or II trials and 2 cohort studies. HRQoL data from 289 SSc patients treated with AHSCT and 125 treated with intravenous CYC as a comparator with median 1.25-4.5 years follow-up were included. HRQoL was evaluated with the HAQ Disability Index (HAQ-DI; 275 patients), the 36-item Short Form Health Survey (SF-36; 249 patients) and the European Quality of Life 5-Dimensions questionnaire (EQ-5D; 138 patients). The quality of the studies was moderate to low. AHSCT was associated with significant improvement in the HAQ-DI (P = 0.02-<0.001), SF-36 Physical Component Summary score (P = 0.02-<0.0001) and EQ-5D index-based utility score (P < 0.001). The SF-36 Mental Component Summary score improved in the ASSIST (n = 19) and one small retrospective cohort (n = 30 patients, P = 0.005) but did not improve significantly in 2 randomized controlled trials (n = 200 patients, P = 0.1-0.91).
    Conclusion: AHSCT in severe SSc patients is associated with significant and durable improvement in physical HRQoL.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Cyclophosphamide/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Humans ; Quality of Life ; Scleroderma, Systemic/physiopathology ; Scleroderma, Systemic/psychology ; Scleroderma, Systemic/therapy ; Severity of Illness Index ; Transplantation, Autologous ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2019-09-09
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez300
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    Zs.B 240: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  3. Article ; Online: Impact of systemic sclerosis oral manifestations on patients' health-related quality of life: A systematic review.

    Smirani, Rawen / Truchetet, Marie-Elise / Poursac, Nicolas / Naveau, Adrien / Schaeverbeke, Thierry / Devillard, Raphaël

    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

    2018  Volume 47, Issue 9, Page(s) 808–815

    Abstract: ... manifestations of systemic sclerosis and patients' health-related quality of life.: Methods: A systematic ... different scales to assess the quality of life.: Conclusion: This systematic review demonstrates ... in Systemic Sclerosis Scale) and an impaired quality of life (measured by different scales). Studies were unequal ...

    Abstract Background: Oropharyngeal features are frequent and often understated in the treatment clinical guidelines of systemic sclerosis in spite of important consequences on comfort, aesthetics, nutrition and daily life. The aim of this systematic review was to assess a correlation between the oropharyngeal manifestations of systemic sclerosis and patients' health-related quality of life.
    Methods: A systematic search was conducted using four databases [PubMed
    Results: From 375 screened studies, 6 cross-sectional studies were included in the systematic review. The total number of patients included per study ranged from 84 to 178. These studies reported a statistically significant association between oropharyngeal manifestations of systemic sclerosis (mainly assessed by maximal mouth opening and the Mouth Handicap in Systemic Sclerosis Scale) and an impaired quality of life (measured by different scales). Studies were unequal concerning risk of bias mostly because of low level of evidence, different recruiting sources of samples and different scales to assess the quality of life.
    Conclusion: This systematic review demonstrates a correlation between oropharyngeal manifestations of systemic sclerosis and impaired quality of life, despite the low level of evidence of included studies. Large-scaled studies are needed to provide stronger evidence of this association.
    MeSH term(s) Adult ; Aged ; Cross-Sectional Studies ; Databases, Bibliographic ; Esthetics/psychology ; Female ; Humans ; Male ; Mental Health ; Microstomia/etiology ; Middle Aged ; Oral Health ; Oral Hygiene ; Oropharynx ; Periodontal Diseases/etiology ; Periodontal Diseases/prevention & control ; Pharyngeal Diseases/etiology ; Pharyngeal Diseases/psychology ; Quality of Life ; Risk Assessment ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/psychology ; Surveys and Questionnaires ; Xerostomia/etiology ; Xerostomia/prevention & control
    Language English
    Publishing date 2018-07-05
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1021270-x
    ISSN 1600-0714 ; 0904-2512
    ISSN (online) 1600-0714
    ISSN 0904-2512
    DOI 10.1111/jop.12739
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    Zs.A 825: Show issues Location:
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  4. Article ; Online: The impact of systemic sclerosis on health-related quality of life assessed by SF-36: A systematic review and meta-analysis.

    Li, Lin / Cui, Yafei / Chen, Shengnan / Zhao, Qian / Fu, Ting / Ji, Juan / Li, Liren / Gu, Zhifeng

    International journal of rheumatic diseases

    2018  Volume 21, Issue 11, Page(s) 1884–1893

    Abstract: ... the literature to evaluate the impact of systemic sclerosis (SSc) on the health-related quality of life (HRQoL) assessed ... Objective: The purpose of this meta-analysis was to systematically review ... function, emotional role function, vitality, mental health, social function, body pain, general health) was ...

    Abstract Objective: The purpose of this meta-analysis was to systematically review the literature to evaluate the impact of systemic sclerosis (SSc) on the health-related quality of life (HRQoL) assessed by the Medical Outcomes Short-Form-36 questionnaire (SF-36).
    Methods: A systematic literature search was performed on PubMed, Web of Science and Embase until April 2017 to obtain eligible studies. Random effect model was performed to summarize the scores of each domain. Scores from the SF-36 questionnaire were used as the outcome measurements, and mean differences with 95% confidence intervals were calculated.
    Results: In total, seven studies were eligible for inclusion criteria, comprising 795 SSc patients and 1154 healthy controls. The SF-36 questionnaire score of each domain (physical function, role physical function, emotional role function, vitality, mental health, social function, body pain, general health) was lower in SSc patients than in healthy controls, meanwhile, physical component scale (PCS) and mental component scale (MCS) scores were all lower in patients with SSc than in healthy controls. Likewise, pooled mean scores of PCS and MCS ranged from 31.20 to 52.80, 37.40 to 68.30, respectively. Additionally, the score of PCS was lower than that of MCS in SSc patients.
    Conclusions: This meta-analysis showed that SSc patients had lower HRQoL than healthy controls, and SSc had negative influence on the HRQoL of patients. This indicates that clinical workers should pay more attention to SSc patients' HRQoL, so as to improve global health of patients with SSc.
    MeSH term(s) Adult ; Aged ; Case-Control Studies ; Female ; Health Status ; Humans ; Male ; Mental Health ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Quality of Life ; Reproducibility of Results ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/physiopathology ; Scleroderma, Systemic/psychology ; Scleroderma, Systemic/therapy ; Surveys and Questionnaires
    Language English
    Publishing date 2018-11-14
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.13438
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    Zs.A 6098: Show issues Location:
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  5. Article ; Online: Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis: protocol for a living systematic review.

    Discepola, Marie-Nicole / Carboni-Jiménez, Andrea / Kwakkenbos, Linda / Henry, Richard S / Boruff, Jill / Krishnan, Ankur / Boström, Carina / Culos-Reed, S Nicole / Hudson, Marie / Leader, David M / Mattsson, Malin / Mouthon, Luc / Wojeck, Robyn / Yakes Jimenez, Elizabeth / Sauve, Maureen / Welling, Joep / Guillot, Geneviève / Benedetti, Andrea / Thombs, Brett D

    BMJ open

    2021  Volume 11, Issue 5, Page(s) e047428

    Abstract: ... a considerable negative impact on health-related quality of life. Non-pharmacological interventions could be ... The proposed living systematic review aims to identify and evaluate randomised controlled trial (RCT) evidence ... All RCTs included in a previous systematic review that sought studies published between 1990 and March 2014 ...

    Abstract Introduction: Systemic sclerosis (SSc; scleroderma) is a rare, chronic, autoimmune disease with a high level of burden, a significant impact on the ability to carry out daily activities, and a considerable negative impact on health-related quality of life. Non-pharmacological interventions could be provided to potentially improve mental and physical health outcomes. However, the effectiveness of non-pharmacological interventions on health and well-being among individuals with SSc has not been well established. The proposed living systematic review aims to identify and evaluate randomised controlled trial (RCT) evidence on the effectiveness of non-pharmacological and non-surgical interventions on mental and physical health outcomes and on the delivery of such services in SSc.
    Methods and analysis: Eligible studies will be RCTs that examine non-pharmacological and non-surgical interventions aimed at improving health outcomes among individuals with SSc or the delivery of services intended to improve healthcare or support of people with SSc (eg, support groups). All RCTs included in a previous systematic review that sought studies published between 1990 and March 2014 will be evaluated for inclusion. Additional trials will be sought from January 2014 onwards using a similar, augmented search strategy developed by a health sciences librarian. We will search the MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Library and Web of Science databases and will not restrict by language. Two independent reviewers will determine the eligibility of identified RCTs and will extract data using a prespecified standardised form in DistillerSR. Meta-analyses will be considered if ≥2 eligible RCTs report similar non-pharmacological interventions and comparable health outcomes. We will conduct a qualitative synthesis for interventions that cannot be synthesised via meta-analysis.
    Ethics and dissemination: We will post initial and ongoing results via a website, publish results periodically via peer-reviewed journal publication, and present results at patient-oriented events.
    Prospero registration number: CRD42020219914.
    MeSH term(s) Chronic Disease ; Humans ; Outcome Assessment, Health Care ; Quality of Life ; Scleroderma, Systemic/therapy ; Systematic Reviews as Topic
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-047428
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  6. Article: Oral-Health-Related Quality of Life in Adult Patients with Rheumatic Diseases-A Systematic Review.

    Schmalz, Gerhard / Patschan, Susann / Patschan, Daniel / Ziebolz, Dirk

    Journal of clinical medicine

    2020  Volume 9, Issue 4

    Abstract: Objectives: The aim of this systematic review was to assess the oral-health-related quality ... of life (OHRQoL) of adult patients with rheumatic diseases.: Material and methods: A systematic ... arthritis (RA, seven studies), systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease ...

    Abstract Objectives: The aim of this systematic review was to assess the oral-health-related quality of life (OHRQoL) of adult patients with rheumatic diseases.
    Material and methods: A systematic literature search was performed, including clinical studies on adults (aged at least 18 years) with a verified diagnosis of rheumatic disease.
    Results: 26 out of 41 clinical studies including rheumatoid arthritis (RA, seven studies), systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease (BD, four), systemic lupus erythematosus (SLE, one) and ankylosing spondylitis (AS, one) were found. In 15 studies, a healthy control group was recruited. The short form of the Oral Health Impact Profile (OHIP 14) was most frequently applied. The majority of studies (14/15) reported worse OHRQoL in patients with rheumatic disease compared to healthy individuals. In particular, patients with SS (salivary flow and composition) or BD (oral ulcers) showed a relation between OHRQoL and disease-specific oral manifestations. Most studies investigating subscales of OHRQoL (5/6) found the subscale physical disability to be predominantly affected in patients with rheumatic diseases. About half of the studies reported impaired psychosocial aspects.
    Conclusion: Patients with rheumatic diseases exhibit reduced OHRQoL, especially in diseases with oral manifestations like SS and BD. Physical affections due to oral diseases and psychosocial impairments caused by disease-related parameters must be recognized within patient-centered dental care.
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9041172
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  7. Article ; Online: Effects of non-pharmacological and non-surgical interventions on health outcomes in systemic sclerosis

    Jill Boruff / Elizabeth Yakes Jimenez / Luc Mouthon / Linda Kwakkenbos / Maureen Sauve / Marie Hudson / Joep Welling / Andrea Carboni-Jiménez / Geneviève Guillot / Malin Mattsson / S Nicole Culos-Reed / Marie-Nicole Discepola / Richard S Henry / David M Leader / Robyn Wojeck

    BMJ Open, Vol 11, Iss

    protocol for a living systematic review

    2021  Volume 5

    Abstract: ... a considerable negative impact on health-related quality of life. Non-pharmacological interventions could be ... The proposed living systematic review aims to identify and evaluate randomised controlled trial (RCT) evidence ... All RCTs included in a previous systematic review that sought studies published between 1990 and March 2014 ...

    Abstract Introduction Systemic sclerosis (SSc; scleroderma) is a rare, chronic, autoimmune disease with a high level of burden, a significant impact on the ability to carry out daily activities, and a considerable negative impact on health-related quality of life. Non-pharmacological interventions could be provided to potentially improve mental and physical health outcomes. However, the effectiveness of non-pharmacological interventions on health and well-being among individuals with SSc has not been well established. The proposed living systematic review aims to identify and evaluate randomised controlled trial (RCT) evidence on the effectiveness of non-pharmacological and non-surgical interventions on mental and physical health outcomes and on the delivery of such services in SSc.Methods and analysis Eligible studies will be RCTs that examine non-pharmacological and non-surgical interventions aimed at improving health outcomes among individuals with SSc or the delivery of services intended to improve healthcare or support of people with SSc (eg, support groups). All RCTs included in a previous systematic review that sought studies published between 1990 and March 2014 will be evaluated for inclusion. Additional trials will be sought from January 2014 onwards using a similar, augmented search strategy developed by a health sciences librarian. We will search the MEDLINE, Embase, CINAHL, PsycINFO, Cochrane Library and Web of Science databases and will not restrict by language. Two independent reviewers will determine the eligibility of identified RCTs and will extract data using a prespecified standardised form in DistillerSR. Meta-analyses will be considered if ≥2 eligible RCTs report similar non-pharmacological interventions and comparable health outcomes. We will conduct a qualitative synthesis for interventions that cannot be synthesised via meta-analysis.Ethics and dissemination We will post initial and ongoing results via a website, publish results periodically via peer-reviewed journal publication, and present ...
    Keywords Medicine ; R
    Subject code 306
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Oral-Health-Related Quality of Life in Adult Patients with Rheumatic Diseases—A Systematic Review

    Gerhard Schmalz / Susann Patschan / Daniel Patschan / Dirk Ziebolz

    Journal of Clinical Medicine, Vol 9, Iss 1172, p

    2020  Volume 1172

    Abstract: Objectives: The aim of this systematic review was to assess the oral-health-related quality of life ... systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease (BD, four), systemic lupus erythematosus ... recruited. The short form of the Oral Health Impact Profile (OHIP 14) was most frequently applied ...

    Abstract Objectives: The aim of this systematic review was to assess the oral-health-related quality of life (OHRQoL) of adult patients with rheumatic diseases. Material and Methods: A systematic literature search was performed, including clinical studies on adults (aged at least 18 years) with a verified diagnosis of rheumatic disease. Results: 26 out of 41 clinical studies including rheumatoid arthritis (RA, seven studies), systemic sclerosis (SSc, five), Sjögren syndrome (SS, eight), Behcet disease (BD, four), systemic lupus erythematosus (SLE, one) and ankylosing spondylitis (AS, one) were found. In 15 studies, a healthy control group was recruited. The short form of the Oral Health Impact Profile (OHIP 14) was most frequently applied. The majority of studies (14/15) reported worse OHRQoL in patients with rheumatic disease compared to healthy individuals. In particular, patients with SS (salivary flow and composition) or BD (oral ulcers) showed a relation between OHRQoL and disease-specific oral manifestations. Most studies investigating subscales of OHRQoL (5/6) found the subscale physical disability to be predominantly affected in patients with rheumatic diseases. About half of the studies reported impaired psychosocial aspects. Conclusion: Patients with rheumatic diseases exhibit reduced OHRQoL, especially in diseases with oral manifestations like SS and BD. Physical affections due to oral diseases and psychosocial impairments caused by disease-related parameters must be recognized within patient-centered dental care.
    Keywords rheumatoid arthritis ; oral health-related quality of life ; quality of life ; systemic sclerosis ; Sjörgen syndrome ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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