Article ; Online: Treatment Adherence and Clinical Outcomes of Patients with Inflammatory Bowel Disease on Biological Agents During the SARS-CoV-2 Pandemic.
Digestive diseases and sciences
2021 Volume 66, Issue 12, Page(s) 4191–4196
Abstract: ... Therapeutic adherence and clinical outcomes were collected for all patients undergoing treatment ... of patients with IBD treated with biological agents in a single-center of a red-zone of the pandemic, and ... of care.: Aims: To describe the clinical outcomes and the fulfilment of the treatment schedule ...
| Abstract | Background: The outbreak of COVID19 evolved rapidly into a global pandemic, forcing hospitals, including inflammatory bowel disease (IBD) referral units, to change their practices to ensure quality of care. Aims: To describe the clinical outcomes and the fulfilment of the treatment schedule of patients with IBD treated with biological agents in a single-center of a red-zone of the pandemic, and to report the patients' perceptions about COVID-19 and the measures adopted at our center. Methods: Therapeutic adherence and clinical outcomes were collected for all patients undergoing treatment with intravenous biologicals and subcutaneous biologicals at our center. A telephone survey was also performed to assess these patients' perceptions of the COVID pandemic and the related measures adopted at their IBD unit. Results: A total of 234 patients were included (117 on intravenous and 117 on subcutaneous biologicals). Only 10% of patients postponed intravenous infusions intentionally and 5% postponed the collection of subcutaneous biologicals at the hospital pharmacy. Only five confirmed COVID-19 cases were registered (2.1%), all of them of mild severity. One hundred and fifty-five patients participated in the survey (77 on intravenous and 78 on subcutaneous drugs). Fear of going to the hospital was the most common reason for postponing biological administrations. Among those on combination therapy, only 7% admitted to have withdrawn immunosuppressants. Conclusions: Adherence to intravenous and subcutaneous biological therapies during the pandemic was high in a single-center cohort of IBD patients even though the cumulative incidence of confirmed COVID-19 was low. |
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| MeSH term(s) | Biological Products/administration & dosage ; Biological Products/adverse effects ; COVID-19/prevention & control ; COVID-19/transmission ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/immunology ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Crohn Disease/immunology ; Cross-Sectional Studies ; Delivery of Health Care, Integrated/organization & administration ; Drug Administration Schedule ; Drug Therapy, Combination ; Fear ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Immunosuppressive Agents/administration & dosage ; Infusions, Intravenous ; Injections, Subcutaneous ; Male ; Medication Adherence ; Patient Satisfaction ; Time Factors ; Treatment Outcome | |||||
| Chemical Substances | Biological Products ; Immunosuppressive Agents | |||||
| Language | English | |||||
| Publishing date | 2021-01-19 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Observational Study | |||||
| ZDB-ID | 304250-9 | |||||
| ISSN | 1573-2568 ; 0163-2116 | |||||
| ISSN (online) | 1573-2568 | |||||
| ISSN | 0163-2116 | |||||
| DOI | 10.1007/s10620-020-06807-0 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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