Article: Profiling of Oral Microbiota and Cytokines in COVID-19 Patients.
2021 Volume 12, Page(s) 671813
Abstract: ... microbiota structure and inflammatory profile of 26 naive severe coronavirus disease 2019 (COVID-19) patients ... immunoassays, respectively. A significant diminution in species richness was observed in COVID-19 patients ... Recent data from transcriptome analysis show that the oral cavity mucosa harbors high levels ...
| Abstract | The presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been recently demonstrated in the sputum or saliva, suggesting how the shedding of viral RNA outlasts the end of symptoms. Recent data from transcriptome analysis show that the oral cavity mucosa harbors high levels of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2), highlighting its role as a double-edged sword for SARS-CoV-2 body entrance or interpersonal transmission. Here, we studied the oral microbiota structure and inflammatory profile of 26 naive severe coronavirus disease 2019 (COVID-19) patients and 15 controls by 16S rRNA V2 automated targeted sequencing and magnetic bead-based multiplex immunoassays, respectively. A significant diminution in species richness was observed in COVID-19 patients, along with a marked difference in beta-diversity. Species such as |
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| Language | English |
| Publishing date | 2021-07-30 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2587354-4 |
| ISSN | 1664-302X |
| ISSN | 1664-302X |
| DOI | 10.3389/fmicb.2021.671813 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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