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  1. Article ; Online: Immunomodulation

    Adeboboye, Covenant Femi / Oladejo, Babayemi Olawale / Adebolu, Tinuola Tokunbo

    European Journal of Biological Research 10(3) 217-224

    a broad perspective for patients' survival of COVID-19 infection

    2020  

    Abstract: ... COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises ... to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering ...

    Abstract The pathogenesis of the SARS-CoV-2 virus is yet to be well understood. However, patients with the virus show clinical manifestations which are very similar to those of SARS-CoV and MERS-CoV. This and other scientific findings reveal that acute respiratory distress syndrome (ARDS) is the main cause of death in most COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises from an aggressive uncontrolled systemic inflammatory response that results from the release of large numbers of pro-inflammatory cytokines. This review seeks to draw the attention of the scientific community to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering the development of this hyper-inflammatory process by suggesting drugs that targets the implicated immune cells, receptors, cytokines and inflammatory pathways without having generalized effect on the entire immune system.
    Keywords Coronavirus ; COVID-19 ; Inflammation ; Cytokines ; Immunomodulation ; covid19
    Subject code 610
    Publishing date 2020-07-22
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Immunomodulation

    Covenant Femi Adeboboye / Babayemi Olawale Oladejo / Tinuola Tokunbo Adebolu

    European Journal of Biological Research, Vol 10, Iss

    a broad perspective for patients’ survival of COVID-19 infection

    2020  Volume 3

    Abstract: ... COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises ... to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering ...

    Abstract The pathogenesis of the SARS-CoV-2 virus is yet to be well understood. However, patients with the virus show clinical manifestations which are very similar to those of SARS-CoV and MERS-CoV. This and other scientific findings reveal that acute respiratory distress syndrome (ARDS) is the main cause of death in most COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises from an aggressive uncontrolled systemic inflammatory response that results from the release of large numbers of pro-inflammatory cytokines. This review seeks to draw the attention of the scientific community to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering the development of this hyper-inflammatory process by suggesting drugs that targets the implicated immune cells, receptors, cytokines and inflammatory pathways without having generalized effect on the entire immune system. DOI: http://dx.doi.org/10.5281/zenodo.3956771
    Keywords Coronavirus ; COVID-19 ; Inflammation ; Cytokines ; Immunomodulation ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher TMKarpinski Publisher, Tomasz M. Karpiński
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Immunomodulation

    Adeboboye, Covenant Femi / Oladejo, Babayemi Olawale / Adebolu, Tinuola Tokunbo

    European Journal of Biological Research; Vol 10 No; 217-224 ; 2449-8955

    a broad perspective for patients’ survival of COVID-19 infection

    2020  Volume 3, Issue : July-September 2020

    Abstract: ... COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises ... to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering ...

    Abstract The pathogenesis of the SARS-CoV-2 virus is yet to be well understood. However, patients with the virus show clinical manifestations which are very similar to those of SARS-CoV and MERS-CoV. This and other scientific findings reveal that acute respiratory distress syndrome (ARDS) is the main cause of death in most COVID-19 patients. A vital mechanism for the development of the ARDS is cytokine storm which arises from an aggressive uncontrolled systemic inflammatory response that results from the release of large numbers of pro-inflammatory cytokines. This review seeks to draw the attention of the scientific community to the possibilities of improving the clinical outcome of COVID-19 patients based on the knowledge of altering the development of this hyper-inflammatory process by suggesting drugs that targets the implicated immune cells, receptors, cytokines and inflammatory pathways without having generalized effect on the entire immune system. DOI: http://dx.doi.org/10.5281/zenodo.3956771
    Keywords covid19
    Subject code 610
    Language English
    Publishing date 2020-07-22
    Publisher JBródka Publisher
    Publishing country pl
    Document type Article ; Online
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  4. Book ; Online ; E-Book: COVID-19 and immunomodulation with special emphasis on nutraceutical and herbal formulation

    Kesharwani, Rajesh Kumar / Keservani, Raj K.

    2024  

    Abstract: The unique volume, COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal ... in preventing and treating COVID-19. It demonstrates the beneficial immunomodulatory properties ... antioxidants, trace elements, vitamins, vaccines, etc., for COVID-19. The information provided here details how ...

    Author's details edited by Rajesh K. Kesharwani, Raj K. Keservani
    Abstract "The unique volume, COVID-19 and Immunomodulation with Special Emphasis on Nutraceutical and Herbal Formulation, covers recent advances in the management, prevention, and application of nutraceuticals and herbs in preventing and treating COVID-19. It demonstrates the beneficial immunomodulatory properties of nutraceuticals, spices, polyphenols, customary (traditional) medications, natural products, ayurveda, antioxidants, trace elements, vitamins, vaccines, etc., for COVID-19. The information provided here details how the use of selected nutraceuticals and herbals can be helpful, similarly to pharmacological remedies, in stopping some COVID-19-associated complications in infected patients. It will be a valuable resource for researchers in pharmaceutical science, medicine, COVID and related diseases, and others"--
    Keywords COVID-19 (Disease)/Prevention ; COVID-19 (Disease)/Treatment ; COVID-19 (Disease)/Nutritional aspects ; Immune response/Regulation
    Subject code 616.24144
    Language English
    Size 1 online resource (306 pages)
    Publisher Apple Academic Press Inc
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-334780-0 ; 1-000-80024-5 ; 1-003-34780-0 ; 1-000-80029-6 ; 9781774913178 ; 978-1-00-334780-4 ; 978-1-000-80024-1 ; 978-1-003-34780-4 ; 978-1-000-80029-6 ; 1774913178
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Immunomodulation in COVID-19.

    Ingraham, Nicholas E / Lotfi-Emran, Sahar / Thielen, Beth K / Techar, Kristina / Morris, Rachel S / Holtan, Shernan G / Dudley, R Adams / Tignanelli, Christopher J

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 6, Page(s) 544–546

    MeSH term(s) Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Humans ; Immunologic Factors/immunology ; Immunologic Factors/therapeutic use ; Immunomodulation/immunology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Immunologic Factors
    Keywords covid19
    Language English
    Publishing date 2020-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30226-5
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  6. Article ; Online: Immunomodulation and immunotherapeutics of COVID-19.

    Garg, Sourbh Suren / Sharma, Atulika / Gupta, Jeena

    Clinical immunology (Orlando, Fla.)

    2021  Volume 231, Page(s) 108842

    Abstract: ... unexpected post-COVID complications including kidney failure, myocardial infarction, or multiorgan failure ...

    Abstract Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease 2019, a pandemic which was originated from Wuhan city of China. The pandemic has affected millions of people worldwide. The pathogenesis of SARS-CoV-2 is characterized by a cytokine storm in the blood (cytokinemia) and tissues, especially the lungs. One of the major repercussions of this inflammatory process is the endothelial injury-causing intestinal bleeding, coagulopathy, and thromboembolism which result in various sudden and unexpected post-COVID complications including kidney failure, myocardial infarction, or multiorgan failure. In this review, we have summarized the immune responses, biochemical changes, and inflammatory responses in the human body after infection with the SARS-CoV-2 virus. The increased amount of inflammatory cytokines, chemokines, and involvement of complement proteins in inflammatory reaction increase the risk of occurrence of disease.
    MeSH term(s) COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Humans ; Immunomodulation ; Immunotherapy ; Inflammation/pathology ; Inflammation/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-08-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2021.108842
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: COVID-19 and gut immunomodulation.

    Roy, Koushik / Agarwal, Sidra / Banerjee, Rajib / Paul, Manash K / Purbey, Prabhat K

    World journal of gastroenterology

    2021  Volume 27, Issue 46, Page(s) 7925–7942

    Abstract: The disease coronavirus disease 2019 (COVID-19) is a severe respiratory illness that has emerged ... in addition to respiratory symptoms in many COVID-19 patients, and some patients show just the GI symptoms ... for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the cells; (2) About half of the severe COVID-19 patients ...

    Abstract The disease coronavirus disease 2019 (COVID-19) is a severe respiratory illness that has emerged as a devastating health problem worldwide. The disease outcome is heterogeneous, and severity is likely dependent on the immunity of infected individuals and comorbidities. Although symptoms of the disease are primarily associated with respiratory problems, additional infection or failure of other vital organs are being reported. Emerging reports suggest a quite common co-existence of gastrointestinal (GI) tract symptoms in addition to respiratory symptoms in many COVID-19 patients, and some patients show just the GI symptoms. The possible cause of the GI symptoms could be due to direct infection of the epithelial cells of the gut, which is supported by the fact that (1) The intestinal epithelium expresses a high level of angiotensin-converting enzyme-2 and transmembrane protease serine 2 protein that are required for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into the cells; (2) About half of the severe COVID-19 patients show viral RNA in their feces and various parts of the GI tract; and (3) SARS-CoV-2 can directly infect gut epithelial cells
    MeSH term(s) COVID-19 ; Dysbiosis ; Humans ; Immunity ; Immunomodulation ; SARS-CoV-2
    Language English
    Publishing date 2021-12-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i46.7925
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  8. Article ; Online: Nangibotide for precision immunomodulation in septic shock and COVID-19.

    Neupane, Maniraj / Kadri, Sameer S

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 10, Page(s) 855–857

    MeSH term(s) Humans ; Shock, Septic/drug therapy ; COVID-19 ; Oligopeptides ; Immunomodulation
    Chemical Substances nangibotide (59HD7BLX9H) ; Oligopeptides
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00220-5
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    Zs.A 7041: Show issues Location:
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  9. Article: Post-COVID-19 Encephalitis With Claustrum Sign Responsive to Immunomodulation.

    Humayun, Mian Bilal / Khalid, Sarah / Khalid, Hamza / Zahoor, Warda / Malik, Waseem T

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35363

    Abstract: We describe a case of encephalitis following coronavirus disease 2019 (COVID-19) in a six-and ... The patient was unvaccinated for COVID-19. Subsequent magnetic resonance imaging revealed a bilateral ... reported moderate diffuse encephalopathy. The patient tested negative for COVID-19 ...

    Abstract We describe a case of encephalitis following coronavirus disease 2019 (COVID-19) in a six-and-a-half-year-old girl who presented with acute onset confusion and jerky movements of the limbs. The patient was unvaccinated for COVID-19. Subsequent magnetic resonance imaging revealed a bilateral "claustrum sign" on T2 and fluid-attenuated inversion recovery (FLAIR) images and electroencephalogram reported moderate diffuse encephalopathy. The patient tested negative for COVID-19 by polymerase chain reaction, had positive serology for COVID-19 indicating past infection, and had a negative autoimmune panel and infectious workup. She was treated on the lines of post-infectious encephalitis with immunomodulatory therapies such as high-dose intravenous steroids and intravenous immunoglobulins. She responded significantly and had complete resolution of her symptoms; therefore, further supporting the suspicion of an immune-mediated etiology. Cases of post-COVID-19 encephalitis have been reported all over the world; however, most cases are based on speculation and temporal associations and therefore more research is required to optimize treatment guidelines.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35363
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  10. Article ; Online: Cryptococcal meningitis post-covid-19 infection: Immunomodulation, a double-edged sword.

    Abdessamad, Hilal W / Achkar, Michel / Al Zoghbi, Amal / Fleifel, Mohamad / Ousta, Abdul Rahman / Kassar, Ahmad / Samaha, Nadia L / Nemr, Rita / Farra, Anna / Mokhbat, Jacques E / Husni, Rola

    Journal of infection in developing countries

    2023  Volume 17, Issue 5, Page(s) 623–630

    Abstract: ... of immunomodulation in severe COVID-19, especially in the elderly population. This article describes the case and ... Immunomodulatory agent use in severe coronavirus disease 2019 (COVID-19) may predispose such infections. Here ... extensively reviews cryptococcal disease post-COVID-19 literature, highlighting the risk ...

    Abstract Cryptococcal meningitis is an opportunistic infection associated with altered immunity. Immunomodulatory agent use in severe coronavirus disease 2019 (COVID-19) may predispose such infections. Here, we present a 75-year-old male patient who presented with fever and altered general status after severe COVID-19 infection and developed cryptococcal meningitis. Opportunistic infection may arise from the use of immunomodulation in severe COVID-19, especially in the elderly population. This article describes the case and extensively reviews cryptococcal disease post-COVID-19 literature, highlighting the risk from immunosuppressive treatment.
    MeSH term(s) Aged ; Male ; Humans ; Meningitis, Cryptococcal/diagnosis ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/epidemiology ; Cryptococcus neoformans ; COVID-19 ; Opportunistic Infections ; Immunomodulation
    Language English
    Publishing date 2023-05-31
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.17170
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