Article ; Online: Alemtuzumab in Covid era.
Multiple sclerosis and related disorders
2021 Volume 51, Page(s) 102908
Abstract: ... recommended to evaluate the beneficial-risk profile of alemtuzumab in pandemic era. ... infection despite alemtuzumab immunosuppressive treatment CONCLUSIONS: The risk of serious COVID-19 disease ... with alemtuzumab and to consider COVID-19 infection related relapse in the MS patients. Further research is ...
| Abstract | Background: The SARS-CoV-2 pandemic impact on people with Multiple Sclerosis (pwMS) continues to worry. The disease modifying therapies in pwMS can add a more severe risk of infection when compared to the general population. Alemtuzumab is an anti-CD52 monoclonal antibody and it is one of the most immunosuppressive drugs used in Multiple Sclerosis (MS). Case description: We present a case of Covid-19 infection that occurred in a 24-year-old woman with MS and treated with alemtuzumab. The infection occurred 4 months after administration of the first course of alemtuzumab and had a benign course with subsequent development of antibodies. Furthermore, we present a brief review of the literature on similar published cases. Discussion: We reviewed 17 articles concerning COVID-19 infection in MS patients in treatment with Alemtuzumab. In our case and all screened cases no severe course of disease was noted and no fatality was observed. Systematic compilation of this observation comforts clinicians about the course of Covid-19 infection despite alemtuzumab immunosuppressive treatment CONCLUSIONS: The risk of serious COVID-19 disease in MS patients treated with alemtuzumab is unknown. Physicians need to monitor carefully pwMS treated with alemtuzumab and to consider COVID-19 infection related relapse in the MS patients. Further research is recommended to evaluate the beneficial-risk profile of alemtuzumab in pandemic era. |
|---|---|
| MeSH term(s) | Adult ; Alemtuzumab/therapeutic use ; COVID-19 ; Female ; Humans ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/epidemiology ; Pandemics ; SARS-CoV-2 ; Young Adult |
| Chemical Substances | Alemtuzumab (3A189DH42V) |
| Language | English |
| Publishing date | 2021-03-18 |
| Publishing country | Netherlands |
| Document type | Case Reports ; Letter |
| ZDB-ID | 2645330-7 |
| ISSN | 2211-0356 ; 2211-0348 |
| ISSN (online) | 2211-0356 |
| ISSN | 2211-0348 |
| DOI | 10.1016/j.msard.2021.102908 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.